Placental inflammation in a fetal demise of a SARS-CoV-2-asymptomatic, COVID-19-unvaccinated pregnant woman: a case-report DOI Creative Commons

Maricarmen Abrego-Navarro,

Rodrigo Villalobos,

Jaime E. Sanchez

et al.

BMC Pregnancy and Childbirth, Journal Year: 2024, Volume and Issue: 24(1)

Published: April 25, 2024

Abstract Background Intrauterine fetal demise is a recognized complication of coronavirus disease 2019 in pregnant women and associated with histopathological placental lesions. The pathological mechanism virus-induced immune response the placenta are not fully understood. A detailed description severe acute respiratory syndrome 2 (SARS-CoV-2)-induced inflammation during crucial for improved clinical management. Case presentation We report case 27-week gestation SARS-CoV-2-asymptomatic unvaccinated woman without comorbidities or other risk factors negative pregnancy outcomes diagnosis intrauterine demise. Histopathological findings corresponded to patterns subacute throughout anatomic compartments placenta, showing chorioamnionitis, chronic villitis deciduitis, accompanied by maternal vascular malperfusion. Our immunohistochemistry results revealed infiltration CD68 + macrophages, CD56 Natural Killer cells scarce CD8 T cytotoxic lymphocytes at site inflammation, SARS-CoV-2 nucleocapsid located stromal chorion chorionic villi, decidual cells. Conclusion This describes novel lesions plasma cells, neutrophils, natural killer malperfusion SARS-CoV-2-infected asymptomatic better understanding inflammatory effects exerted will enable strategies management avoid fatal future transmission waves.

Language: Английский

Placental inflammation in a fetal demise of a SARS-CoV-2-asymptomatic, COVID-19-unvaccinated pregnant woman: a case-report DOI Creative Commons

Maricarmen Abrego-Navarro,

Rodrigo Villalobos,

Jaime E. Sanchez

et al.

BMC Pregnancy and Childbirth, Journal Year: 2024, Volume and Issue: 24(1)

Published: April 25, 2024

Abstract Background Intrauterine fetal demise is a recognized complication of coronavirus disease 2019 in pregnant women and associated with histopathological placental lesions. The pathological mechanism virus-induced immune response the placenta are not fully understood. A detailed description severe acute respiratory syndrome 2 (SARS-CoV-2)-induced inflammation during crucial for improved clinical management. Case presentation We report case 27-week gestation SARS-CoV-2-asymptomatic unvaccinated woman without comorbidities or other risk factors negative pregnancy outcomes diagnosis intrauterine demise. Histopathological findings corresponded to patterns subacute throughout anatomic compartments placenta, showing chorioamnionitis, chronic villitis deciduitis, accompanied by maternal vascular malperfusion. Our immunohistochemistry results revealed infiltration CD68 + macrophages, CD56 Natural Killer cells scarce CD8 T cytotoxic lymphocytes at site inflammation, SARS-CoV-2 nucleocapsid located stromal chorion chorionic villi, decidual cells. Conclusion This describes novel lesions plasma cells, neutrophils, natural killer malperfusion SARS-CoV-2-infected asymptomatic better understanding inflammatory effects exerted will enable strategies management avoid fatal future transmission waves.

Language: Английский

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