Mechanistic insights into Wnt–β-catenin pathway activation and signal transduction

Nature Reviews Molecular Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Language: Английский

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The role of VANGL2 in glioma oncogenesis and progression: insights into expression profiles and prognostic relevance

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 13, 2025

The Wnt/planar cell polarity (PCP) signaling pathway is pivotal in regulating various biological processes such as early embryonic development, neural crest migration, and cancer invasion. Despite advances understanding the role of Wnt/PCP dysregulation tumorigenesis, numerous unanswered questions remain. Our study focused on VANGL2, a core PCP gene, to elucidate its potential mechanistic involvement development. A systematic analysis was conducted assess VANGL2 expression patterns at both transcriptional proteomic levels. Functional enrichment performed investigate pathways associated with glioma. In vitro experiments were impact glioma behaviors. Furthermore, rigorous methodologies employed survival control for confounding factors. We identified substantial upregulation gene low-grade (LGG) glioblastoma (GBM). genes positively underscored their Notch pluripotency stem cells. further confirmed that promotes invasion, proliferation, tumor sphere formation. significant correlation between increased IDH mutation patients. Elevated predictor poor prognosis prognostic features critical roles oncogenesis progression.

Language: Английский

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The Molecular Basis of Pediatric Brain Tumors: A Review with Clinical Implications

Cancers, Journal Year: 2025, Volume and Issue: 17(9), P. 1566 - 1566

Published: May 4, 2025

Central nervous system (CNS) tumors are the most common solid malignancy in pediatric population. These lesions result of aberrant cell signaling step proteins, which normally regulate proliferation. Mitogen-activated protein kinase (MAPK) pathways and tyrosine receptors involved tumorigenesis low-grade gliomas. High-grade gliomas may carry similar mutations, but loss epigenetic control is dominant molecular event; it can occur either due to histone mutations or inappropriate binding unbinding DNA on histones. Therefore, despite absence genetic alteration classic oncogenes tumor suppressor genes, uncontrolled transcription results tumorigenesis. Isocitric dehydrogenase (IDH) do not predominate compared their adult counterpart. Embryonic include medulloblastomas, bear transcription-regulating pathways, such as wingless-related integration sites sonic hedgehog pathways. They also relate high expression Myc family genes. Atypical teratoid rhabdoid harbor alterations molecules that contribute ATP hydrolysis chromatin. with multilayered rosettes associated microRNA impaired translation. Ependymomas exhibit great variability. As far supratentorial concerned, major events NFkB Hippo Posterior fossa further divided into two types different prognoses. Type A group damage repair molecules. Lastly, germ a heterogeneous group. Among them, germinomas manifest KIT receptor subgroup family.

Language: Английский

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Protocol for dissecting Drosophila pupae and visualizing RNA expression using hybridization chain reaction

STAR Protocols, Journal Year: 2024, Volume and Issue: 5(4), P. 103456 - 103456

Published: Nov. 21, 2024

Language: Английский

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