A review on antimicrobial strategies in mitigating biofilm-associated infections on medical implants

Current Research in Microbial Sciences, Journal Year: 2024, Volume and Issue: 6, P. 100231 - 100231

Published: Jan. 1, 2024

Biomedical implants are crucial in providing support and functionality to patients with missing or defective body parts. However, carry an inherent risk of bacterial infections that biofilm-associated lead significant complications. These often result implant failure, requiring replacement by surgical restoration. Given these complications, it is study the biofilm formation mechanism on various biomedical will help prevent failures. Therefore, this comprehensive review explores types (e.g., dental implant, orthopedic tracheal stent, breast central venous catheter, cochlear urinary intraocular lens, heart valve) medical devices (hemodialyzer pacemaker) use. In addition, those implants, their pathogenesis were discussed. Furthermore, article critically reviews approaches combating implant-associated infections, a special emphasis novel non-antibiotic alternatives mitigate infections.

Language: Английский

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Cu-doped bioactive glass with enhanced in vitro bioactivity and antibacterial properties

Ceramics International, Journal Year: 2023, Volume and Issue: 50(3), P. 5091 - 5103

Published: Nov. 22, 2023

This work aimed to optimize, produce and characterize Cu-doped bioactive glasses which are antibacterial without the addition of antibiotics obtained via ion exchange in an aqueous solution. According morphological, compositional structural analyses, 0.001 M was selected as most optimal concentration The doped glass then compared undoped one investigate effect Cu-doping on surface composition bioactivity. found enhance bioactivity kinetics following hydroxyapatite formation, evidenced by X-ray diffraction, energy dispersive spectroscopy, zeta potential measurements. Besides that, titration measurements confirmed that did not alter chemical stability both inflammatory physiological pH range. Moreover, leaching ability Cu2+-ions, inflammatory-mimicking conditions, measured, followed in-depth study properties, using two protocols distinguish between antiadhesive, antibacterial, antibiofilm effects. For protocols, a reduction metabolic activity Colony-Forming Unit after 24 h against Staphylococcus aureus Multi-Drug resistance strain evidenced. These results showed could show for bone surgery applications.

Language: Английский

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Cationic substitution effects in phosphate-based bioceramics - A way towards superior bioproperties

Ceramics International, Journal Year: 2024, Volume and Issue: 50(19), P. 34479 - 34509

Published: June 29, 2024

Language: Английский

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Advantages of electrochemically deposited bioceramic-coating on magnesium implant for anti-corrosion and bone regeneration

Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: 59, P. 105936 - 105936

Published: Feb. 1, 2025

Language: Английский

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Enhancing the antibacterial and bioactive properties of micro-arc oxidized titanium alloy coatings through hydrothermal treatment incorporating silver and copper ions

Ceramics International, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Effect of Ultrasound Power on the Properties of Cu-doped Fluorohydroxyapatite Coating Prepared via Ultrasonic-Assisted Electrodeposition for Biomedical Applications

Materials Chemistry and Physics, Journal Year: 2024, Volume and Issue: unknown, P. 129996 - 129996

Published: Oct. 1, 2024

Language: Английский

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[Progress in antibacterial/osteogenesis dual-functional surface modification strategy of titanium-based implants].

PubMed, Journal Year: 2023, Volume and Issue: 37(10), P. 1300 - 1313

Published: Oct. 15, 2023

To review antibacterial/osteogenesis dual-functional surface modification strategy of titanium-based implants, so as to provide reference for subsequent research.The related research literature on implants in recent years was reviewed, and the progress summarized based different kinds antibacterial substances osteogenic active substances.At present, includes: ① Combined coating antibiotics substances. It is characterized that can be directly released around which improve bioavailability drugs reduce systemic toxicity. ② antimicrobial peptides The have a wide spectrum, bacteria are not easy produce drug resistance them. ③ inorganic agent Metal ions or metal nanoparticles agents broad-spectrum properties various mechanisms, but their high-dose application usually has cytotoxicity, they often combined with activity eliminate cytotoxicity. In addition, coatings such silicon nitride, calcium silicate, graphene also good properties. ④ organic frameworks/osteogenic high specific area porosity frameworks effectively package transport bioactive molecules. ⑤ substances/osteogenic substancecs. Quaternary ammonium compounds, polyethylene glycol, N-haloamine, other compounds properties, hydroxyapatite activity.The factors affect osteogenesis mainly include structure types substances, process. At there lack clinical verification strategies implants. optimal combination, ratio, dose-effect mechanism, corresponding preparation process bone-active needed constantly studied improved.对钛基植入物的抗菌/促成骨双功能表面改性策略进行综述，为后续研究提供参考。.查阅近年来钛基植入物抗菌和促成骨双功能表面改性方法的相关研究文献，就不同种类的抗菌物质和促成骨活性物质进行分类总结。.目前钛基植入物抗菌/促成骨双功能表面改性策略包括：① 抗生素/促成骨活性物质复合涂层策略。特点是抗生素可以直接在钛基植入物周围释放，在提高药物生物利用率的同时降低全身毒性。② 抗菌肽/促成骨活性物质复合涂层策略。特点是抗菌肽具有广泛抗菌谱，细菌不易对其产生耐药性。③ 无机抗菌剂/促成骨活性物质复合涂层策略。金属离子或金属纳米颗粒抗菌剂具有广谱抗菌性和多种抗菌机制，但其高剂量应用通常具有细胞毒性，因此常将其与促成骨活性物质联合应用以减少或消除细胞毒性。另外，氮化硅、硅酸钙、石墨烯等无机物涂层也具有良好的抗菌与促成骨性能。④ 有机金属骨架/促成骨活性物质复合涂层策略。有机金属骨架的高比表面积和大孔隙率可实现抗菌物质和生物活性分子等物质的有效封装和传输。⑤ 有机物/促成骨活性物质复合涂层策略。季铵化合物、聚乙二醇、N-卤胺等有机物具有良好的抗菌性能，常与羟基磷灰石等促成骨活性物质联合涂层。.影响钛基植入物表面抗菌与促成骨性能的因素主要包括抗菌物质、促成骨活性物质的结构与种类以及涂层工艺。目前对于钛基植入物抗菌/促成骨双功能表面改性的多种策略均缺乏临床验证，抗菌物质与促成骨活性物质的最佳组合、配比、量效机制、以及相应的涂层制备工艺均有待进一步研究。.

Language: Английский

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Influencing factors and evaluation methods for early stability of immediate implant.

PubMed, Journal Year: 2024, Volume and Issue: 49(2), P. 305 - 311

Published: Feb. 28, 2024

At present, implant restoration has become a hot research topic in the field of prosthodontics. The in-depth studies new materials and technologies enable immediate implantation, early loading to be realized, which meets needs patients for shortening course obtaining better aesthetic effects. However, compared with traditional delayed implantation technology, it is equally challenging clinicians how achieve even improve initial long-term stability implants order raise success rate restoration. influenced by combination factors, including implant, patient's condition, surgical procedure. Recently, there have been lot on influencing factors common methods bone healing. Summarizing analyzing them can provide reference preoperative evaluation, plan timing later stage.

Language: Английский

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Cytocompatible and antibacterial Fe-, Cu- and Zn-substituted calcium hydroxyapatite materials for skin applications

Ceramics International, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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