Foods,
Journal Year:
2024,
Volume and Issue:
13(17), P. 2847 - 2847
Published: Sept. 7, 2024
This
study
addresses
the
growing
interest
in
natural
functional
ingredients
by
evaluating
prebiotic
and
health-promoting
functions
of
honeybee
brood
biopeptides
(HBb-Bps)
their
conjugates.
The
purpose
was
to
investigate
antioxidant
activities,
enzyme
inhibition
properties,
effects
on
probiotic
growth
short-chain
fatty
acid
(SCFA)
production.
HBb-Bps
were
conjugated
with
honey,
glucose,
fructose
via
Maillard
reaction.
Antioxidant
activities
assessed
using
DPPH
ABTS
assays.
inhibitory
amylase,
pancreatic
lipase,
angiotensin-converting
(ACE)
measured.
Probiotic
SCFA
production
evaluated
L.
plantarum
TISTR846,
lactis
TISTR1464.
conjugates
exhibited
enhanced
post-Maillard
They
showed
moderate
inhibition,
which
decreased
after
conjugation.
However,
ACE
increased
significantly
promoted
production,
further
enhancement
Overall,
demonstrate
significant
functions,
suggesting
potential
as
foods
nutraceuticals.
Further
research
should
focus
vivo
and,
given
solubility
stability
these
could
be
incorporated
into
food
formulations,
such
health
beverages,
protein
bars,
other
fortified
designed
deliver
specific
benefits.
Biomedical Materials,
Journal Year:
2024,
Volume and Issue:
19(3), P. 032003 - 032003
Published: April 4, 2024
Abstract
In
terms
of
biomedical
tools,
nanodiamonds
(ND)
are
a
more
recent
innovation.
Their
size
typically
ranges
between
4
to
100
nm.
ND
produced
via
variety
methods
and
known
for
their
physical
toughness,
durability,
chemical
stability.
Studies
have
revealed
that
surface
modifications
functionalization
significant
influence
on
the
optical
electrical
properties
nanomaterial.
Consequently,
functional
groups
NDs
applications
in
domains,
including
drug
administration,
gene
delivery,
immunotherapy
cancer
treatment,
bio-imaging
diagnose
cancer.
Additionally,
biocompatibility
is
critical
requisite
vivo
vitro
interventions.
This
review
delves
into
these
aspects
focuses
advances
modification
strategies
various
surrounding
diagnosis
treatment.
Furthermore,
prognosis
its
clinical
translation
has
also
been
discussed.
Journal of Tissue Engineering,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 1, 2024
Short
sequences
of
amino
acids
called
peptides
have
a
wide
range
biological
functions
and
the
potential
to
treat
number
diseases.
Bioactive
can
be
derived
from
different
sources,
including
marine
organisms,
synthetic
design,
making
them
versatile
candidates
for
production
therapeutic
agents.
Their
effects
span
across
areas
such
as
antimicrobial
activity,
cells
proliferation
migration,
synthesis
collagen,
more.
This
current
review
explores
fascinating
realm
bioactive
promising
agents
skin
wound
healing.
focuses
on
multifaceted
specific
peptides,
shedding
light
their
revolutionize
field
dermatology
regenerative
medicine.
It
delves
into
how
these
stimulate
collagen
synthesis,
inhibit
inflammation,
accelerate
tissue
regeneration,
ultimately
contributing
effective
repair
wounds.
The
findings
underscore
significant
role
several
types
play
in
enhancing
healing
processes
offer
insights
improving
quality
life
individuals
with
injuries
dermatological
conditions.
versatility
allows
development
tailored
treatments
catering
patient
needs.
As
continuing
delve
deeper
there
is
immense
further
exploration
innovation.
Future
endeavors
may
involve
optimization
peptide
formulations,
elucidation
underlying
molecular
cellular
mechanisms.
Separations,
Journal Year:
2024,
Volume and Issue:
11(6), P. 166 - 166
Published: May 27, 2024
Honey
is
a
natural
product
that
used
by
large
number
of
people
because
its
distinctive
compositional
constituents,
which
have
considerable
impact
on
market
value.
The
combination
amino
acids
and
sugars
found
in
honey’s
composition,
along
with
peptide
content,
could
potentially
provide
several
benefits
to
human
health.
During
the
past
few
years,
cutting-edge
techniques
been
developed
for
purpose
investigating,
identifying,
characterizing
peptides
are
produced
from
honey
bees.
Therefore,
this
review
examine
current
trends
technological
advancements
study
bee-derived
peptides,
focusing
innovative
methods.
Furthermore,
explores
various
attributes
components,
including
defensin-1.
In
addition,
investigates
methods
separating
purifying
as
well
factors
affect
these
Additionally,
defensin-1,
bees,
discussed
antioxidant
antimicrobial
capabilities.
focuses
omic
bee
significance
artificial
intelligence
tools
their
investigation.
Consequently,
paper
delves
into
significant
obstacles
faced
researchers
scientists
studying
while
also
offering
an
extensive
range
fascinating
opportunities
possibilities
future
research
those
interested
groundbreaking
discoveries
area.
Toxics,
Journal Year:
2023,
Volume and Issue:
12(1), P. 25 - 25
Published: Dec. 28, 2023
Honey
bees
are
constantly
threatened
due
to
the
wide
use
of
pesticides.
This
study
presents
effects
deltamethrin
on
mortality,
olfactory
learning,
and
memory
formation
native
Saudi
bee
Apis
mellifera
jemenitica.
Topical
oral
application
realistic
field
serial
dilutions
(250,
125,
62.5,
25
ppm)
caused
significant
mortality
at
4,
12,
24,
48
h
posttreatment.
Bee
increased
with
increasing
concentration
insecticide
all
tested
posttreatment
times.
Highest
was
observed
24
after
both
exposure
routes.
Food
consumption
gradually
decreased
during
exposure.
The
LC50
determined
for
topical
(86.28
ppm,
36.16
29.19
respectively)
(35.77
32.53
30.78
Oral
led
significantly
higher
than
4
12
h,
but
routes
were
equally
toxic
h.
sublethal
concentrations
(LC10,
LC20,
LC30)
impaired
learning
conditioning
trials,
as
well
2,
Thus,
inhibits
unable
memorize
learned
task.
Type
1
diabetes
is
a
chronic
condition
that
results
from
the
destruction
of
insulin-producing
β-cells
in
pancreas.
Current
treatments
for
type
diabetes,
such
as
insulin
therapy
and
pancreatic
islet
transplantation,
have
several
limitations
and,
hence
not
quite
effective
long
run.
As
current
methods
fail
to
slow
disease
development,
novel
strategies
development
bioartificial
pancreas
are
being
seriously
considered.
Over
last
decade,
research
has
focused
on
tissue
engineering,
which
aids
design
biological
alternatives
repair
replacement
non-functional
or
damaged
organs.
Three
dimensional
(3D)
bioprinting
technology
employs
3D
printing
generate
tissue-like
structures
biomaterials
cells,
offers
promising
solution
treatment
by
providing
ability
functional
endocrine
tissue.
Bioprinted
therefore
an
important
aspect
engineering
because
they
been
found
replicate
native
extracellular
matrix,
promoting
cell
survival
proliferation.
In
this
review,
we
extensively
discussed
about
particularly
focussing
choice
biomaterials,
growth
factors,
essential
considerations.
Additionally,
key
challenges
perspectives
towards
recapitulation
function
organ
technologies
also
discussed.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 15, 2024
Introduction
As
an
important
social
insect,
honey
bees
play
crucial
roles
in
agricultural
production,
sustainable
development
of
and
the
balance
natural
environment.
However,
recent
years,
Israeli
acute
paralysis
virus
(IAPV)
chronic
bee
(CBPV),
main
pathogens
paralysis,
have
continuously
harmed
colonies
caused
certain
losses
to
beekeeping
industry.
Some
farms
are
located
wild
or
remote
mountainous
areas,
samples
from
these
cannot
be
sent
laboratory
for
testing
a
timely
manner,
thereby
limiting
accurate
rapid
diagnosis
disease.
Methods
results
In
this
study,
we
used
reverse
transcription–recombinase
polymerase
amplification–lateral
flow
dipstick
(RT–RPA–LFD)
method
dual
detection
IAPV
CBPV.
RPA
primers
LFD
probes
were
designed
separately
their
conserved
genes.
Primers
screened,
forward
primer
ratios,
reaction
times,
temperatures
optimized.
According
optimization
tests,
optimal
temperature
RT–RPA
is
37°C,
when
combined
with
LFD,
naked
eye
requires
<20
min.
The
developed
RPA–LFD
specifically
targets
CBPV
has
no
cross-reactivity
other
common
viruses.
addition,
minimum
limit
RT–RPA–LFD
101
copies/μL.
Conclusion
Based
suitable
clinical
can
field
