Comparison Between Autologous Albumin Gel and Liquid Platelet-Rich Fibrin Mixture Versus Connective Tissue Graft to Modify the Gingival Phenotype: A Randomized Controlled Trial DOI Open Access

Sara Abdulhak,

Tarek Kassem,

Yasser Alsayed Tolibah

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: June 8, 2024

Objectives To assess changes in gingival thickness (GTH) and the width of keratinized tissue (KTW) following treatment with either connective graft (CTG) or an albumin gel-platelet-rich fibrin mixture (Alb-PRF). Materials methods Twenty sites were included a split-mouth design involving 10 patients thin phenotype mandibular anterior region. The sample was randomly divided into two groups, Alb-PRF applied to experimental group CTG used for control group. GTH KTW measured at baseline after one, three, six months. Results increased both groups during all follow-up periods. However, no statistically significant differences (p > 0.05) between observed At three months, exhibited significantly higher < 0.001). Additionally, showed superior increase 0.05). Conclusion Within constraints this study, application modifying phenotypes proved be effective therapeutic option, potentially serving as alternative CTGs. Although resulted thicker gingiva, demonstrated greater enhancement KTW.

Language: Английский

Apicoectomy versus apical curettage in combination with or without L-PRF application: a randomized clinical trial DOI Creative Commons
Serap Gülsever, Şeyda Erşahan, Yelda Erdem Hepşenoğlu

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 8, 2025

This study compared the efficacy of apicoectomy and apical curettage with without leukocyte- platelet-rich fibrin (L-PRF) in treating large periapical lesions. Sixty-four adults (30 male, 34 female) a previously endodontically treated tooth lesion were randomized into four groups (n = 16): retrograde obturation (RG), orthograde (OG), RG + L-PRF, OG L-PRF. All participants underwent root canal retreatment two sessions. The group root-end resection MTA obturation, L-PRF application to bone defect following protocol, resection, protocol. Clinical radiographic assessments performed preoperatively, at 1 week 1, 3, 6, 9, 12 months postoperatively. At follow-up visits, pain scores, swelling, mobility, tenderness percussion (T-PER), palpation (T-PAL), presence fistula clinically assessed. Periapical radiography determined index (PAI) score measured area (PALA). Kruskal–Wallis test was effect single independent variable (factor) on dependent variable. No statistically significant differences identified between for preoperative PAI fistula, T-PER, or T-PAL (p > 0.05). postoperative showed significantly lower T-PER. PALA values higher healing rates 9 months. Both achieved over 90% It concluded that combination effectively treats lesions promotes both short- long-term offers less invasive alternative, especially when crown-to-root ratio is concern. Trial registration: protocol registered ClinicalTrials.gov (NCT05847647).

Language: Английский

Citations

0
Three-dimensional volumetric analysis of bone regeneration following jaw cyst enucleation with and without an autologous albumin gel-platelet-rich fibrin mixture (Alb-PRF): a randomized controlled clinical trial DOI Creative Commons
Mohamed Shokry, Lydia Melek,

Tasneem Amer

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 8, 2025

Abstract Introduction The presence of an osseous cavity after cyst enucleation is a clinical challenge that needs to be considered. Using pure autologous concentrations platelets, platelet-rich fibrin (PRF), as graft material removal has shown promising effects. However, PRF limitations in terms durability, it usually resorbs within 10–14 days, thus Mourão et al. introduced new technique for preparation obtain albumin gel-platelet-rich mixture (Alb-PRF), material, can remain stable 4–6 months with the ability regenerate bone. This research aimed evaluate effect Alb-PRF on bone regeneration jaw via 3-dimensional (3D) volumetric analysis. Methods Twenty participants, cysts, were split into two groups. group included 10 individuals treated by and application, control conventionally without any additives. Cone beam computed tomography (CBCT) was conducted immediately following surgery (T1) six later (T2) measure volume residual mean density regenerated using On-demand 3D viewer. Paired t test used compare postoperative immediate results post-6-months results, whereas Student group. Results At 6-month follow-up, had declined increased significantly both (P 1 < 0.001) compared values. Although changes greater than group, there no noticeable difference between ( P = 0.821) 0.533), respectively. Conclusion There conventional blood clots enucleation. Trial registration trial retrospectively registered at Clinicaltrial.gov registry (Registration ID #NCT05658900). It first submitted 12/12/2022 posted 21/12/2022.

Language: Английский

Citations

0
The efficacy of Platelet and Leukocyte Rich Fibrin (L-PRF) in the healing process and bone repair in oral and maxillofacial surgeries: a systematic review DOI
Eduardo Dias Ribeiro, Ilan Hudson Gomes de Santana,

Mayara Rebeca Martins Viana

et al.

Clinical Oral Investigations, Journal Year: 2024, Volume and Issue: 28(7)

Published: July 5, 2024

Language: Английский

Citations

3
Investigating the Biological Efficacy of Albumin-Enriched Platelet-Rich Fibrin (Alb-PRF): A Study on Cytokine Dynamics and Osteoblast Behavior DOI Open Access
Emanuelle Stellet Lourenço,

Neilane Rodrigues Santiago Rocha,

Renata de Lima Barbosa

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11531 - 11531

Published: Oct. 27, 2024

The development of effective biomaterials for tissue regeneration has led to the exploration blood derivatives such as leucocyte- and platelet-rich fibrin (L-PRF). A novel variant, Albumin-Enriched Platelet-Rich Fibrin (Alb-PRF), been introduced improve structural stability bioactivity, making it a promising candidate bone regeneration. This study aimed evaluate Alb-PRF’s capacity cytokine growth factor release, along with its effects on proliferation, differentiation, mineralization human osteoblasts in vitro. Alb-PRF membranes were analyzed using histological, scanning electron microscopy, fluorescence microscopy techniques. Cytokine release was quantified over seven days, osteoinductive potential evaluated MG-63 osteoblast-like cells. Structural analysis showed biphasic, highly cellularized material that releases lower levels inflammatory cytokines higher concentrations platelet-derived (PDGF) vascular endothelial (VEGF) compared L-PRF. exhibited early alkaline phosphatase activity vitro (p < 0.05) significantly increased OPG/RANKL mRNA ratio 0.05). These results indicate scaffold repair, warranting further vivo clinical assessments confirm suitability applications.

Language: Английский

Citations

2
Comparison Between Autologous Albumin Gel and Liquid Platelet-Rich Fibrin Mixture Versus Connective Tissue Graft to Modify the Gingival Phenotype: A Randomized Controlled Trial DOI Open Access

Sara Abdulhak,

Tarek Kassem,

Yasser Alsayed Tolibah

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: June 8, 2024

Objectives To assess changes in gingival thickness (GTH) and the width of keratinized tissue (KTW) following treatment with either connective graft (CTG) or an albumin gel-platelet-rich fibrin mixture (Alb-PRF). Materials methods Twenty sites were included a split-mouth design involving 10 patients thin phenotype mandibular anterior region. The sample was randomly divided into two groups, Alb-PRF applied to experimental group CTG used for control group. GTH KTW measured at baseline after one, three, six months. Results increased both groups during all follow-up periods. However, no statistically significant differences (p > 0.05) between observed At three months, exhibited significantly higher < 0.001). Additionally, showed superior increase 0.05). Conclusion Within constraints this study, application modifying phenotypes proved be effective therapeutic option, potentially serving as alternative CTGs. Although resulted thicker gingiva, demonstrated greater enhancement KTW.

Language: Английский

Citations

0