Collagen-based materials in male genitourinary diseases and tissue regeneration DOI Creative Commons
Fangyuan Li,

XinHuang,

Ruiying Wang

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 6(1)

Published: Dec. 1, 2024

Abstract Male genitourinary dysfunction causes serious physical or mental distress, such as infertility and psychological harm, which leads to impaired quality of life. Current conventional treatments involving drug therapy, surgical repair, tissue grafting have a limited effect on recovering the function fertility organs. To address these limitations, various biomaterials been explored, with collagen-based materials increasingly gaining attention for reconstructing male system due their superior biocompatibility, biodegradability, low antigenicity, biomimetic 3D matrix characteristics, hemostatic efficacy, regeneration capabilities. This review covers recent biomedical applications including treatment erectile dysfunction, premature ejaculation, penile girth enlargement, prostate cancer, Peyronie's disease, chronic kidney etc. Although there are relatively few clinical trials, promising results existing studies animal models reveal bright future in diseases. Graphic

Language: Английский

Bioengineering Approaches for Male Infertility: From Microenvironmental Regeneration to in vitro Fertilization DOI
Selin Önen, Merve Gizer,

İmran Özge Çolak

et al.

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Recent Progress of Induced Spermatogenesis In Vitro DOI Open Access
Siqi Liu, Jiang Wu, Xin Zhao

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8524 - 8524

Published: Aug. 5, 2024

Sperm, a crucial gamete for reproduction in sexual reproduction, is generated through the proliferation, differentiation, and morphological transformations of spermatogonial stem cells within specialized microenvironment testes. Replicating this environment artificially presents challenges. However, interdisciplinary advancements physics, materials science, cell engineering have facilitated utilization innovative materials, technologies, structures inducing vitro sperm production. This article offers comprehensive overview research progress on production by categorizing techniques into two major systems based matrix-based non-matrix-based approaches, respectively. Detailed discussions are provided both types technology comparisons their similarities differences, as well advancements. The aim to provide researchers field with panoramic view while presenting our own perspectives prospects.

Language: Английский

Citations

0
Collagen-based materials in male genitourinary diseases and tissue regeneration DOI Creative Commons
Fangyuan Li,

XinHuang,

Ruiying Wang

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 6(1)

Published: Dec. 1, 2024

Abstract Male genitourinary dysfunction causes serious physical or mental distress, such as infertility and psychological harm, which leads to impaired quality of life. Current conventional treatments involving drug therapy, surgical repair, tissue grafting have a limited effect on recovering the function fertility organs. To address these limitations, various biomaterials been explored, with collagen-based materials increasingly gaining attention for reconstructing male system due their superior biocompatibility, biodegradability, low antigenicity, biomimetic 3D matrix characteristics, hemostatic efficacy, regeneration capabilities. This review covers recent biomedical applications including treatment erectile dysfunction, premature ejaculation, penile girth enlargement, prostate cancer, Peyronie's disease, chronic kidney etc. Although there are relatively few clinical trials, promising results existing studies animal models reveal bright future in diseases. Graphic

Language: Английский

Citations

0