Evaluation of osseointegration of plasma treated polyaryletherketone maxillofacial implants

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 13, 2025

Osseointegration is a crucial property of biomaterials used for bone defect repair. While titanium the gold standard in craniofacial surgeries, various polymeric are being explored as alternatives. However, materials can be bioinert, hindering integration with surrounding tissues. In this investigation, plasma ion immersion implantation (PIII)-treated polyether ether ketone (PEEK) and (PEK) implants were assessed sheep maxilla mandible model. Defects filled PIII-treated PEEK PEK implants, produced through fused filament fabrication (FFF) selective laser sintering (SLS), respectively. Positive controls grade 23 via melting, while untreated served negative controls. Surface analyses using scanning electron microscopy atomic force revealed favorable properties. was qualitatively quantitatively at 8-, 10-, 12-weeks post-implantation, showing significantly improved outcomes both compared to The study suggests PIII treatment enhances FFF-printed PEEK's osseointegration, SLS-printed achieves comparable osseointegration 3D printed titanium. These findings underscore surface modification strategies' potential biomaterials, offering insights into developing alternative implant enhanced biocompatibility capabilities clinical outcomes.

Language: Английский

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Bioactive surface modifications on dental implants: a systematic review and meta-analysis of osseointegration and longevity

Clinical Oral Investigations, Journal Year: 2024, Volume and Issue: 28(11)

Published: Oct. 11, 2024

Abstract Background Bioactive surface modifications have been proposed to enhance osseointegration and longevity of dental implants. This study aimed systematically review perform a meta-analysis on the effectiveness various bioactive coatings in promoting bone integration improving implant longevity. Methods A systematic was conducted, including studies that investigated titanium Outcomes interest were bone-to-implant contact (BIC) over 30-day period. Data extracted analyzed using RevMan 5 (version 5.4.1), with forest plots generated represent mean difference (MD) 95% confidence intervals (CI) under random effects model. Results The showed significant improvement BIC for surface-modified implants, an overall MD 7.29 (95% CI [2.94, 11.65]). Heterogeneity analysis indicated moderate heterogeneity (Tau² = 18.57, Chi² 16.08, df 8, P 0.04, I² 50%). test effect yielded Z 3.28 ( 0.001). For longevity, 7.52 [3.18, 11.85]), 17.28, 14.95, 0.06, 47%). 3.40 0.0007). Conclusion changes significantly improved lifespan Collagen-based consistently encouraged early integration, while BMP-2 combinations effective osseointegration. Optimizing agent doses critical achieving desired outcomes.

Language: Английский

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Volumetric measurement of manually drawn segmentations in cone beam computed tomography images of newly formed bone after sinus floor augmentation with bovine-derived bone substitutes

Journal of Stomatology Oral and Maxillofacial Surgery, Journal Year: 2025, Volume and Issue: unknown, P. 102221 - 102221

Published: Jan. 1, 2025

Precise volumetric measurement of newly formed bone after maxillary sinus floor augmentation (MSFA) can help clinicians in planning for dental implants. This study aimed to introduce a novel modular framework facilitate calculations based on manually drawn segmentations user-defined areas interest cone-beam computed tomography (CBCT) images MATERIAL & METHODS: Two interconnected networks manual segmentation defined volume and implant calculation, respectively, were used parallel. The data manufacturers reference. efficacy this was demonstrated through practical applications collecting CBCT from patients MSFA with the same quantity two different bovine-derived substitutes: xenohybrid composite (Group I, n = 10) hydroxyapatite II, 10). approved by central Ethical Review Board federal state Lower Austria (approval number: GS4-EK-4/451-2021). volumes measured immediately (T1) 6 months (T2) before insertion implant. All measurements analyzed inter- intravariability. P-values >0.05 obtained t-test analysis RESULTS: delineation Group II (n easier than that I due visual contrast scan. mean 861.65 ± 290.02 mm³ at T1 875.9 288.96 T2. shows moderate dispersion around value, which indicates variability DISCUSSION: proposed network may be useful development computer-based diagnostic systems assessing success replacement materials. stability achieved materials comparable.

Language: Английский

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Advances in the Development and Application of Human Organoids: Techniques, Applications, and Future Perspectives

Cell Transplantation, Journal Year: 2025, Volume and Issue: 34

Published: Jan. 1, 2025

Organoids are three-dimensional (3D) cell cultures derived from human pluripotent stem cells or adult that recapitulate the cellular heterogeneity, structure, and function of organs. These microstructures invaluable for biomedical research due to their ability closely mimic complexity native tissues while retaining genetic material. This fidelity organ systems positions organoids as a powerful tool advancing our understanding biology enhancing preclinical drug testing. Recent advancements have led successful development variety organoid types, reflecting broad range organs tissues. progress has expanded application across several domains, including regenerative medicine, where offer potential tissue replacement repair; disease modeling, which allows study mechanisms progression in controlled environment; discovery evaluation, provide more accurate platform testing efficacy safety; microecological research, they contribute interactions between microbes host review provides comprehensive overview historical technology, highlights key achievements ongoing challenges field, discusses current emerging applications both laboratory clinical practice.

Language: Английский

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Rubus Coreanus Enhances Peri-Implant Bone Healing and Biomineralization in Ovariectomized and Healthy Rats

Biology, Journal Year: 2025, Volume and Issue: 14(2), P. 139 - 139

Published: Jan. 29, 2025

Estrogen deficiency contributes to osteoporosis and can therefore compromise the peri-implant bone. Hence, this study evaluated bone healing when Rubus coreanus (RC) was administered orally in ovariectomized healthy rats. Forty 4-month-old female rats were divided into four groups: SHAM (healthy rats), SHAM/RC treated with RC), OVX (ovariectomized OVX/RC RC). The oral administration of RC started thirty days after ovariectomy, implant placement rat tibia occurred ninety ovariectomy. Euthanasia sixty implantation. analyses performed included removal torque, RT-PCR, confocal microscopy, immunolabeling. A significance level p < 0.05 considered for all tests. highest reverse torque values observed group, followed by group. Confocal microscopy showed greatest biomineralization RT-PCR data indicated that decreased RANKL/OPG ratio both conditions. Immunohistochemistry demonstrated a balance between formation resorption groups, especially stimulating osteoblastogenesis groups. In conclusion, enhanced rats, stronger effects suggesting estrogen may enhance its efficacy. These findings support RC's potential as prophylactic therapeutic agent.

Language: Английский

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Advancements in osteoblast sourcing, isolation, and characterization for dental tissue regeneration: a review

BioMedical Engineering OnLine, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 8, 2025

Primary osteoblasts are essential for bone formation and regeneration, making them pivotal in dental applications, including periodontal ridge augmentation, implant osseointegration. Sourced from various tissues like alveolar bone, calvarial mandibular maxillary bones, long marrow-derived stem cells (BMSCs), each type of osteoblast presents unique advantages limitations related to yield, accessibility, clinical relevance. Given these variables, selecting an appropriate source is crucial experimental consistency translational application dentistry. This review synthesizes data vitro, animal, studies provide a comprehensive overview sourcing, isolation, characterization research. Sources were reviewed based on anatomical relevance, while isolation methods compared assess their impact cell behavior phenotype retention. The evaluates such as enzymatic digestion, explant culture, differentiation BMSCs, alongside techniques morphological analysis, gene expression profiling, mineralization assays. analysis shows that bone-derived offer high relevance due similarity oral structures but limited by low yield invasive collection. Calvarial higher yields, useful material testing, though they lack biomechanical compatibility with environments. BMSCs renewable significant regenerative potential require precise protocols. In vitro contribute mechanistic insights, animal models bridge the gap application, despite challenges standardization interspecies variability. highlights importance sources research optimize outcomes implant-related therapies. variability across study designs underscores need standardized protocols targeted systematic reviews within specific settings. These findings framework future osteoblast-based guide effective translation therapies into practice.

Language: Английский

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Impact of three-dimensional stabilization thread design on biomechanical fixation and osseointegration of endosteal implants

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2025, Volume and Issue: unknown, P. 107004 - 107004

Published: April 1, 2025

Language: Английский

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Effect of insertion load on insertion torque value

Journal of Dental Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Biological characterization of the osteogenic, antibacterial and anti-inflammatory properties of fullerene-modified zirconia and titanium alloy implant surfaces

Diamond and Related Materials, Journal Year: 2025, Volume and Issue: unknown, P. 112339 - 112339

Published: April 1, 2025

Language: Английский

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Nonlinear Finite Element Analysis of Bone–Implant Contact in Three Short Dental Implant Models with Varying Osseointegration Percentages

Oral, Journal Year: 2024, Volume and Issue: 4(4), P. 505 - 524

Published: Oct. 22, 2024

Objectives: Dental implants have become a cornerstone of restorative dentistry, providing long-lasting method for tooth replacement. The degree osseointegration has significant effect on biomechanical stability at the bone–implant contact (BIC), determining continued efficacy these implants. However, exact consequences changing levels different implant designs, especially in bones with variable densities, are not well known. Methods: This study used 3D finite element analysis (FEA) to look performance three short dental implants: BioMet 3iT3, Straumann® Standard Plus Short-Regular Neck (SPS-RN), and Short-Wide (SPS-WN). paper tested four stages osseointegration: 25%, 50%, 75%, 100% both high-density (bone type III) low-density IV) cancellous bone. It also created examined realistic CAD models under static occlusal loading conditions assess stress distribution major strains contact. Results: discovered that as increases, von Mises principal go down significantly all types. SPS-WN had lowest strain values, bone low density. These reductions demonstrate increased mechanical interface becomes more capable dispersing stresses, minimizing potential localized deformation resorption. Conclusions: results highlight importance achieving optimum reduce increase lifespan performed better tests than others, when were ideal. makes it great choice clinical applications need long-term success.

Language: Английский

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