Controlled Magnesium Ion Delivery via Mg‐Sputtered Nerve Conduit for Enhancing Peripheral Nerve Regeneration DOI

Hyewon Kim,

Jieun Kwon,

Hyeok Kim

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

Abstract Autologous nerve grafting remains the gold standard for treating peripheral injuries; however, it is constrained by limited donor availability, need secondary surgeries, and sensory loss at site. Biodegradable material‐based conduits have emerged as a promising alternative to address these limitations enhance regeneration. Among materials, magnesium stands out due its exceptional biocompatibility, biofunctionality, neuroprotective properties. Despite potential, magnesium's rapid corrosion rate controlled ion release necessitate advanced modifications, such development of Mg alloys. However, approaches often face challenges, including viability concerns material hardness, which can hinder repair damage surrounding tissues. In this study, novel solution introduced sputtering onto soft collagen sheet, achieving while preserving material's nerve‐like softness. This Mg‐sputtered sheet demonstrates excellent biocompatibility significantly improves axon regeneration, muscle reinnervation, functional recovery in sciatic defect model. These findings highlight potential an innovative Mg‐based biodegradable conduit, offering transformative applications across various medical fields.

Language: Английский

Controlled Magnesium Ion Delivery via Mg‐Sputtered Nerve Conduit for Enhancing Peripheral Nerve Regeneration DOI

Hyewon Kim,

Jieun Kwon,

Hyeok Kim

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

Abstract Autologous nerve grafting remains the gold standard for treating peripheral injuries; however, it is constrained by limited donor availability, need secondary surgeries, and sensory loss at site. Biodegradable material‐based conduits have emerged as a promising alternative to address these limitations enhance regeneration. Among materials, magnesium stands out due its exceptional biocompatibility, biofunctionality, neuroprotective properties. Despite potential, magnesium's rapid corrosion rate controlled ion release necessitate advanced modifications, such development of Mg alloys. However, approaches often face challenges, including viability concerns material hardness, which can hinder repair damage surrounding tissues. In this study, novel solution introduced sputtering onto soft collagen sheet, achieving while preserving material's nerve‐like softness. This Mg‐sputtered sheet demonstrates excellent biocompatibility significantly improves axon regeneration, muscle reinnervation, functional recovery in sciatic defect model. These findings highlight potential an innovative Mg‐based biodegradable conduit, offering transformative applications across various medical fields.

Language: Английский

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