Revolutionising oral organoids with artificial intelligence. DOI
Jiawei Yang, Nicholas G. Fischer, Zhou Ye

et al.

PubMed, Journal Year: 2024, Volume and Issue: 5(4), P. 372 - 389

Published: Jan. 1, 2024

The convergence of organoid technology and artificial intelligence (AI) is poised to revolutionise oral healthcare. Organoids - three-dimensional structures derived from human tissues offer invaluable insights into the complex biology diseases, allowing researchers effectively study disease mechanisms test therapeutic interventions in environments that closely mimic vivo conditions. In this review, we first present historical development organoids delve current types organoids, focusing on their use models, regeneration microbiome intervention. We then compare single-source multi-lineage assess latest progress bioprinted, vascularised neural-integrated organoids. next part highlight significant advancements AI, emphasising how AI algorithms may potentially promote for early detection diagnosis, personalised treatment, prediction drug screening. However, our main finding identification remaining challenges, such as data integration critical need rigorous validation ensure clinical reliability. Our viewpoint AI-enabled are still limited applications but, look future, potential transformation AI-integrated microbial interactions discoveries. By synthesising these components, review aims provide a comprehensive perspective state future implications role advancing healthcare improving patient outcomes.

Language: Английский

Current basic and preclinical research for treatment of radiation therapy–induced hyposalivation DOI Creative Commons
Olga J. Baker, Harim Tavares dos Santos, Kihoon Nam

et al.

JADA Foundational Science, Journal Year: 2025, Volume and Issue: 4, P. 100046 - 100046

Published: Jan. 1, 2025

Language: Английский

Citations

0
Revolutionising oral organoids with artificial intelligence. DOI
Jiawei Yang, Nicholas G. Fischer, Zhou Ye

et al.

PubMed, Journal Year: 2024, Volume and Issue: 5(4), P. 372 - 389

Published: Jan. 1, 2024

The convergence of organoid technology and artificial intelligence (AI) is poised to revolutionise oral healthcare. Organoids - three-dimensional structures derived from human tissues offer invaluable insights into the complex biology diseases, allowing researchers effectively study disease mechanisms test therapeutic interventions in environments that closely mimic vivo conditions. In this review, we first present historical development organoids delve current types organoids, focusing on their use models, regeneration microbiome intervention. We then compare single-source multi-lineage assess latest progress bioprinted, vascularised neural-integrated organoids. next part highlight significant advancements AI, emphasising how AI algorithms may potentially promote for early detection diagnosis, personalised treatment, prediction drug screening. However, our main finding identification remaining challenges, such as data integration critical need rigorous validation ensure clinical reliability. Our viewpoint AI-enabled are still limited applications but, look future, potential transformation AI-integrated microbial interactions discoveries. By synthesising these components, review aims provide a comprehensive perspective state future implications role advancing healthcare improving patient outcomes.

Language: Английский

Citations

0