Advances in biomaterials for dental implants: A comprehensive review of progress, challenges, and future trends DOI Open Access

Rushikesh K. Kakde,

Nitin S. Kale,

Gajanan Sanap

et al.

International Journal of Maxillofacial Imaging, Journal Year: 2024, Volume and Issue: 10(4), P. 160 - 168

Published: Dec. 12, 2024

Dental implants have totally transformed restorative dentistry, as this has made tooth loss and edentulism treatable with greater consistency longevity. Therefore, the efficacy of dental is inextricably related to inherent characteristics biomaterials used, which paramount in promoting osseointegration ensuring satisfactory function aesthetics. Through years, growth materials science driven changes toward implants, from some simple complex substances manifesting improved biocompatibility, mechanical strength, chemical resistance. This review will elaborate on progress innovation implant biomaterials, discussing commonly used like titanium, ceramics, new innovations including nanostructured surfaces, bioactive coatings, 3D-printed biomaterials. These are focused be improving integration soft hard tissue, preventing complications such peri-implantitis, bone regeneration. Challenges biodegradability, manufacturing complexity, cost then discussed along strategies overcoming these challenges. It emphasizes future directions that include intelligent artificial intelligence-guided design, sustainable methodologies for developing The current applications prospective opportunities analyzed exemplify revolutionary capacity sophisticated augment clinical effectiveness durability implants.

Language: Английский

Hybrid Biomechanical Design of Dental Implants: Integrating Solid and Gyroid Triply Periodic Minimal Surface Lattice Architectures for Optimized Stress Distribution DOI Creative Commons
Dawit Bogale Alemayehu, Masahiro TODOH, Song‐Jeng Huang

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(2), P. 54 - 54

Published: Feb. 9, 2025

Background: Dental implantology has evolved significantly since the introduction of additive manufacturing, which allows for reproduction natural bone’s porous architecture to improve bone tissue compatibility and address stress distribution issues important long-term implant success. Conventional solid dental implants frequently cause shielding, compromises osseointegration reduces durability. Aim: The current research proposes examine biomechanical efficacy fully hybrid gyroid triply periodic minimum surface (TPMS) latticed across different cell sizes optimize Methods: This study evaluates six implants, including designs with three sizes—FLI_111 (1 mm × 1 mm), FLI_222 (2 2 FLI_333 (3 3 mm)—and TPMS necks in corresponding sizes—HI_111, HI_222, HI_333. To enhance initial stability, a square-threaded design was added into bottom part both lattice implants. also incorporate anti-rotational connections fixation, they undergo clinical viability comparison contemporary designs, finite element analysis (FEA) utilized through nTopology (nTOP 4.17.3) balance stiffness flexibility. mechanical performance under realistic conditions, dynamic mastication loading simulation conducted 1.5 s cycles. Results: findings reveal that particularly exhibited improved characteristics by reducing micromotions at bone–implant interface, improving osteointegration, attaining better distribution. Conclusions: By addressing shielding boosting performance, this work paves way personalized developing technology, results.

Language: Английский

Citations

2
An update on implication of POSS-based nanocomposites in bone tissue engineering: a review DOI

Leyla Bagheri,

Davoud Jafari-Gharabaghlou,

Maedeh Dashti

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: Feb. 18, 2025

The science of Bone tissue engineering (TE) is quickly progressing. Engineering bone usually applications a synthetic extracellular matrix, cells or osteoblasts that can convert to osteoblasts, and adjusting causes boost adhesion, distinction, mineralized construction cells. Extremely porous scaffolds perform an important character in cell planting, propagation, fresh 3D-tissue construction. Reformative medicine track multi-disciplinary approach for the novel substances' development appliance, various defects therapy. presentation polyhedral oligomeric silsesquioxane (POSS) bio-polymeric scaffold has been shown develop biotic attributes hybrid combinations. This review focuses on influence POSS within Chitosan (CS), Hydroxyapatite (HA), zeolite matrixes, drawing, advantages limitations materials mentioned bone.

Language: Английский

Citations

0
Locally Delivered Hydrogel with Sustained Release of Flavonol Compound Kaempferol Mitigates Inflammatory Progression of Periodontitis and Enhances the Gut Microflora Composition in Rats DOI
Ningli Li, Mingzhen Yang,

Miaomiao Feng

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

This study aimed to investigate the effects of a sustained-release composite containing gelatin methacryloyl (Gel) and kaempferol (Ka, K) on experimental periodontitis symptoms in rats. Forty 6-week-old male rats were randomly assigned four treatment groups specific pathogen-free (SPF) environment: Control group (C), model (M), Gel alone (G), Gel_Ka composite-treated (G_K). Treatment periodontal status bilateral maxillary second molars each rat assessed by micro-CT imaging histology. Immunohistochemistry staining was employed examine expression levels inflammatory factors IL-6 MMP9 (associated with M1 macrophages) anti-inflammatory factor CD206 M2 macrophages). Additionally, oral intestinal microbial communities analyzed through 16S rDNA sequencing. Local injection G_K hydrogel effectively suppressed alveolar bone resorption reduced attachment loss inflammation infiltration periodontitis. It but increased CD206, it also abundance gut producing short-chain fatty acids. demonstrates substantial antiperiodontitis effect locally attenuating is associated enhancing composition flora, thus aiding mitigating progression

Language: Английский

Citations

0
Cortical perforation promotes bone regeneration by enhancing nerve growth factor secretion DOI
Jiao Yao, Yitong Liu, Xiaoyan Li

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 755, P. 151562 - 151562

Published: Feb. 28, 2025

Language: Английский

Citations

0
Artificial Single-Layer, Multi-Layer, and Gradient Scaffolds for Enhancing the Healing of Tendon-to-Bone Interfaces: A Mini-Review DOI Creative Commons
Tianyi Song, Lin Guo, Changcheng Wang

et al.

Orthopedic Research and Reviews, Journal Year: 2025, Volume and Issue: Volume 17, P. 105 - 113

Published: March 1, 2025

Tendon healing after ligament or tendon reconstruction remains a significant challenge. Regenerative tissue engineering, an interdisciplinary field that combines biology, materials science, and offers promising solutions. Recent developments have introduced scaffold designed to enhance the proliferation differentiation of tendon-to-bone cells. These scaffolds possessing three-dimensional composites cells biomaterials, proven effective in facilitating curing post-surgery. The successful development interface is critical factor for early rehabilitation functional recovery. In this mini-review, we present comprehensive update on contemporary strategies synthetic scaffold-based their influence healing. We described compositions, structures features single-layer, multi-layer, gradient with special mechanical properties. examined construction engineering from perspectives biomaterials design strategies, providing evaluation advantages disadvantages associated each approach. Ultimately, review articulates clear research directions aimed at achieving breakthroughs future studies.

Language: Английский

Citations

0
Strategies for Fabricating Multi-Material Bone Tissue Constructs DOI
Yusuf Olatunji Waidi

Bioprinting, Journal Year: 2025, Volume and Issue: unknown, P. e00405 - e00405

Published: March 1, 2025

Language: Английский

Citations

0
Embryonic toxicology evaluation of novel Cissus quadrangularis, bioceramics and tendon extracellular matrix incorporated scaffolds for periodontal bone regeneration using zebrafish model DOI

S. Balaji Ganesh,

M. Aravindan,

Gurumoorthy Kaarthikeyan

et al.

Journal of Oral Biology and Craniofacial Research, Journal Year: 2025, Volume and Issue: 15(3), P. 563 - 569

Published: March 26, 2025

Language: Английский

Citations

0
IN VITRO STUDY ON THE SYNTHESIS AND CHARACTERIZATION OF ERBIUM-DOPED HYDROXYAPATITE/BIOGLASS-POLYVINYL ALCOHOL SCAFFOLD FOR PERIODONTAL BONE REGENERATION DOI

M. Sharon,

Nidhita Suresh,

Kaarthikeyan Gurumoorthy

et al.

BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY, Journal Year: 2025, Volume and Issue: unknown, P. 239 - 249

Published: March 7, 2025

Periodontal disease leads to alveolar bone loss, necessitating grafting for regeneration. Traditional grafts, including autografts and allografts, have limitations such as donor site morbidity immune rejection. Bone tissue engineering (BTE) offers an alternative approach using biocompatible scaffolds. This study investigates the potential of erbium-doped hydroxyapatite (HA)-bioglass-polyvinyl alcohol (PVA) composite scaffold Materials Methods: The synthesized HA, bioglass, PVA scaffold. was characterized morphologically Fourier Transform Infrared Spectroscopy (FTIR) Scanning Electron Microscopy (SEM). Biological evaluations included hemostatic behavior, anti-inflammatory response, biocompatibility assessments MTT assay live/dead cell analysis. Results: FTIR confirmed structural integrity with characteristic peaks PVA. SEM revealed a porous, flower-like morphology, promoting attachment nutrient exchange. Hemostatic analysis demonstrated enhanced clot formation, micrographs showing aggregated RBCs on surface, indicating strong efficiency.Anti-inflammatory studies indicated dose-dependent effect, exhibiting significant protein denaturation inhibition at 50 µg. assays high biocompatibility, over 90% viability across tested concentrations. Conclusion: HA/bioglass-PVA excellent potential, properties. These findings suggest its suitability periodontal Further in vivo are required validate clinical applicability.

Language: Английский

Citations

0
Advances in bioink-based 3D printed scaffolds: optimizing biocompatibility and mechanical properties for bone regeneration DOI
Pawan Kumar, Jitender Sharma, Ravinder Kumar

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The development of bioink-based 3D-printed scaffolds has revolutionized bone tissue engineering (BTE) by enabling patient-specific and biomimetic constructs for regeneration.

Language: Английский

Citations

0
Production of Polyvinyl Alcohol/Amoxicillin – Chitosan/Collagen Hybrid Bilayer Membranes for Regeneration of Gingival Tissues DOI Open Access
Ayca Aydin, Songul Ulag, Sabereh Nouri

et al.

Macromolecular Bioscience, Journal Year: 2024, Volume and Issue: 25(1)

Published: Nov. 18, 2024

Abstract Periodontal diseases, if untreated, can cause gum recession and tooth root exposure, resulting in infection irreversible damage. Traditional treatments using autologous grafts are painful often result postoperative complications. Scaffolds offer a less invasive alternative, promoting cell proliferation healing without additional surgery, thus enhancing comfort for patients doctors. This study developed Chitosan (Chit)/Collagen (Col) film surfaces drug‐loaded Polyvinyl Alcohol (PVA)/Amoxicillin (AMX) nanofibers solvent casting electrospinning methods, respectively. The characterized by scanning electron microscopy (SEM), mechanical testing, Fourier Transform Infrared Spectroscopy (FTIR), differential calorimetry (DSC). Biocompatibility antimicrobial properties assessed NIH/3T3 fibroblast cells bacterial cultures. SEM images confirmed the structural integrity of AMX‐loaded 13% PVA nanofibers, while FTIR analysis validated compositional PVA/AMX Chit/Col hybrid surfaces. Cell studies showed over 90% viability + nanofiber bilayer membranes, confirming their biocompatibility. assessment indicated that (0.2%) membrane exhibited superior efficacy against Streptococcus mutans. These findings suggest this enhance growth, promote proliferation, enable controlled drug release, offering significant promise regeneration gingival tissues.

Language: Английский

Citations

0