Precision‐Guided Stealth Missiles in Biomedicine: Biological Carrier‐Mediated Nanomedicine Hitchhiking Strategy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Abstract Nanodrug delivery systems (NDDS) have demonstrated broad application prospects in disease treatment, prevention, and diagnosis due to several advantages, including functionalization capability, high drug‐loading capacity, drug stability protection, the enhanced permeability retention (EPR) effect. However, their clinical translation still faces multiple challenges, rapid clearance by reticuloendothelial system (RES), poor targeting specificity, insufficient efficiency crossing biological barriers. To address these limitations, researchers developed carrier‐mediated nanomedicine hitchhiking strategy (BCM‐NHS), which leverages circulating cells, proteins, or bacteria as natural “mobile carriers” enhance delivery. This approach enables nanocarriers inherit intrinsic properties, endowing them with immune evasion, prolonged circulation, dynamic targeting, biocompatibility, biodegradability, naturally optimized interfaces. Here, a systematic overview of BCM‐NHS is provided. First, review delves into methods nanoparticles (NPs) binding immobilization, encompassing both surface‐attachment‐mediated “backpack” encapsulation‐based “Trojan horse” strategy. Second, classification carriers, cell‐based non‐cell‐based elucidated. Third, physical properties release mechanisms nanomaterials are thoroughly described. Finally, latest applications therapeutic diagnostic contexts across various models tumor, ischemic stroke, pneumonia highlighted.

Language: Английский

Recent advances in DNA nanotechnology for cancer detection and therapy: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142136 - 142136

Published: March 1, 2025

Language: Английский

Stealth Missiles with Precision Guidance: A Novel Multifunctional Nano-Drug Delivery System Based on Biomimetic Cell Membrane Coating Technology

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101922 - 101922

Published: May 1, 2025

Language: Английский