Organochlorine pesticides and epigenetic alterations in brain cancer DOI Creative Commons
Fatemeh Yousefi, Gholamreza Asadikaram, Saeid Karamouzian

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Background: Epigenetic alterations have emerged as critical factors in the pathogenesis of brain cancer, particularly gliomas. This article explores impact organochlorine pesticides (OCPs) on hypermethylation key tumor suppressor genes, and some histone modifications primary (PBT) patients. Methods: study involved 73 patients diagnosed with PBT 15 non-cancerous tissue samples contol . DNA extracted from specimens was used to evaluate methylation status P16 RRP22, using methylation-specific PCR (MSP) technique four marks (H4K16ac, H3K9ac, H4K20me3, H3k4me2) investigate by western blotting. Results: The results MSP revealed P22 P16promoter regions blot analysis demonstrated significantly low levels H3K4me2 comparison controls. regression direct significant correlations between serum OCPs concentration P16. Furthermore, a association observed hypomethylation histones H3K4 H4K20, well hypoacetylation H3K9, levels. Conclusion: that epigenetic play role development tumors, identified contributors these changes. Our research indicated PBT, P16 gene correlates directly found their serum.

Language: Английский

The role of lncRNAs in the interplay of signaling pathways and epigenetic mechanisms in glioma DOI
Can Bora Yildiz,

Jian Du,

K. Naga Mohan

et al.

Epigenomics, Journal Year: 2025, Volume and Issue: 17(2), P. 125 - 140

Published: Jan. 19, 2025

Gliomas, highly aggressive tumors of the central nervous system, present overwhelming challenges due to their heterogeneity and therapeutic resistance. Glioblastoma multiforme (GBM), most malignant form, underscores this clinical urgency dismal prognosis despite treatment regimens. Recent advances in cancer research revealed signaling pathways epigenetic mechanisms that intricately govern glioma progression, offering multifaceted targets for intervention. This review explores dynamic interplay between events regulation context glioma, with a particular focus on crucial roles played by non-coding RNAs (ncRNAs). Through direct indirect targeting, ncRNAs emerge as key regulators shaping molecular landscape glioblastoma across its various stages. By dissecting these intricate regulatory networks, novel patient-tailored strategies could be devised improve patient outcomes devastating disease.

Language: Английский

Citations

0
Organochlorine Pesticides and Epigenetic Alterations in Brain Cancer DOI Creative Commons
Fatemeh Yousefi, Gholamreza Asadikaram, Saeid Karamouzian

et al.

Cellular and Molecular Neurobiology, Journal Year: 2025, Volume and Issue: 45(1)

Published: Feb. 9, 2025

Language: Английский

Citations

0
Long-read sequencing for brain tumors DOI Creative Commons
William J. Shelton,

Sara Zandpazandi,

J. Stephen Nix

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: June 10, 2024

Brain tumors and genomics have a long-standing history given that glioblastoma was the first cancer studied by genome atlas. The numerous continuous advances through decades in sequencing technologies aided advanced molecular characterization of brain for diagnosis, prognosis, treatment. Since implementation biomarkers WHO CNS 2016, has been integrated into diagnostic criteria. Long-read sequencing, also known as third generation is an emerging technique allows longer DNA segments leading to improved detection structural variants epigenetics. These capabilities are opening way better tumors. Here, we present comprehensive summary state art third-generation application tumor We discuss advantages potential new implementations long-read clinical paradigms neuro-oncology patients.

Language: Английский

Citations

0
Organochlorine pesticides and epigenetic alterations in brain cancer DOI Creative Commons
Fatemeh Yousefi, Gholamreza Asadikaram, Saeid Karamouzian

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Background: Epigenetic alterations have emerged as critical factors in the pathogenesis of brain cancer, particularly gliomas. This article explores impact organochlorine pesticides (OCPs) on hypermethylation key tumor suppressor genes, and some histone modifications primary (PBT) patients. Methods: study involved 73 patients diagnosed with PBT 15 non-cancerous tissue samples contol . DNA extracted from specimens was used to evaluate methylation status P16 RRP22, using methylation-specific PCR (MSP) technique four marks (H4K16ac, H3K9ac, H4K20me3, H3k4me2) investigate by western blotting. Results: The results MSP revealed P22 P16promoter regions blot analysis demonstrated significantly low levels H3K4me2 comparison controls. regression direct significant correlations between serum OCPs concentration P16. Furthermore, a association observed hypomethylation histones H3K4 H4K20, well hypoacetylation H3K9, levels. Conclusion: that epigenetic play role development tumors, identified contributors these changes. Our research indicated PBT, P16 gene correlates directly found their serum.

Language: Английский

Citations

0