Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery

Natural Product Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Subterranean microbial communities possess unique and untapped biosynthetic potential.

Language: Английский

---

Gene regulatory network resource aids in predicting trans-acting regulators of biosynthetic gene clusters in Aspergillus fumigatus

mBio, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

ABSTRACT The field of secondary metabolism has greatly benefitted from computational advances in recent years. This been particularly true for fungal natural product studies. Strides genome mining have led to the identification an extraordinary number metabolite biosynthetic gene clusters (BGCs) across Kingdom and metabologenomic platforms can group BGCs into cluster families link them initial chemical structures. Missing are applications focused on identifying BGC regulatory networks. Here, we applied new online network resource, GRAsp ( G ene R egulation Asp ergillus fumigatus ), identify unknown unpredictable trans-acting transcriptional/metabolite production modules. correctly predicted a two-component module composed transcription factors (TFs), RogA r o f g liotoxin) HsfA, which negatively regulate gliotoxin also involved self-protection. functions through repression gliZ, pathway-specific TF, HsfA by activating rogA expression. Furthermore, identified TFs that two lacking TFs, helvolic acid fumitremorgin BGCs, respectively. Finally, known NsdD, was found hexadehydroastechrome BGC. These highlight power inference algorithms uncover networks specialized synthesis. IMPORTANCE Toxic metabolites virulence opportunistic pathogen Aspergillus fumigatus, yet transcriptional regulating remain elusive. Uncovering novel regulators without any prior information is challenging. Computational programs gained prominence research due their accuracy ability handle vast amounts data, including DNA, RNA, protein data. In this study, newly developed computer platform, Gene Regulation A. , used five several toxins, gliotoxin, acid, fumitremorgin, hexadehydroastechrome. work illustrates potential discovering mechanisms regulation examination

Language: Английский

---

Isolation of a novel marine Aspergillus fumigatus strain AFK11 and inhibition of inflammatory mediators

Journal of Biosciences, Journal Year: 2025, Volume and Issue: 50(2)

Published: May 5, 2025

Language: Английский

---

Correction: Seo et al. A Timeline of Biosynthetic Gene Cluster Discovery in Aspergillus fumigatus: From Characterization to Future Perspectives. J. Fungi 2024, 10, 266

Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(9), P. 657 - 657

Published: Sept. 18, 2024

In the original publication [...]

Language: Английский

---

Molecular characterization of gliotoxin synthesis in a biofilm model of Aspergillus fumigatus

Biofilm, Journal Year: 2024, Volume and Issue: 8, P. 100238 - 100238

Published: Nov. 6, 2024

Mycelial growth as biofilm structures and the activation of secondary metabolism leading to release low-molecular-weight molecules (known metabolites), are among previously described strategies used by filamentous fungi

Language: Английский

---