Epigenetic modulation of fungal pathogens: a focus on Magnaporthe oryzae DOI Creative Commons
Hafiz Muhammad Usman Aslam, Mohamad Chikh-Ali, Xin‐Gen Zhou

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 28, 2024

Epigenetics has emerged as a potent field of study for understanding the factors influencing effectiveness human disease treatments and identifying alternations induced by pathogens in host plants. However, there been paucity research on epigenetic control proliferation pathogenicity fungal plant pathogens. Fungal such Magnaporthe oryzae , significant threat to global rice production, provide an important model exploring how mechanisms govern virulence. In M. alterations, DNA methylation, histone modification, non-coding RNAs, regulate gene expression patterns that influence pathogen’s ability infect its host. These modifications can enhance adaptability, allowing pathogen survive diverse environments evade immune responses. Our primary objective is comprehensive review existing shed light these changes lifecycle, invade tissues, overall severity disease. We begin examining alterations occurring their contributions virulence fungus. To advance our similar diseases, we emphasize need address unanswered questions explore future directions. This information crucial developing new antifungal target pathways, which could lead improved management.

Language: Английский

The soil microbial methylome: a tool to explore the role of epigenetic memory in driving soil abiotic legacy effects DOI Creative Commons
Tom Sizmur, Alexey A. Larionov

Soil Biology and Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 109712 - 109712

Published: Jan. 1, 2025

Language: Английский

Citations

0
Spotlight on the hidden treasure of endophytic fungal bioactive metabolites DOI

R. Nischitha,

Sunil Sunil,

L. Gagana Suryavamshi

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 129 - 150

Published: Jan. 1, 2025

Language: Английский

Citations

0
Deletion of the Class 1 Histone Deacetylase PsHos2 Induces Secondary Metabolic Perturbations in the Sea Cucumber-Associated Penicillium sclerotiorum DOI Creative Commons
Peipei Zhao,

Jiaying Lin,

Qingqing Zhang

et al.

Fermentation, Journal Year: 2025, Volume and Issue: 11(4), P. 230 - 230

Published: April 21, 2025

The long-term coexistence of sea cucumber-associated microorganisms with their host enables them to jointly withstand the unique marine ecological environment, and possess great potential for producing various natural products. However, under conventional laboratory conditions, most biosynthetic gene clusters (BGCs) in these remain silent, necessitating establishment effective activation strategies exploring bioactive secondary metabolites (SMs). Histone acetylation status regulates chromatin structure plays a crucial role cellular physiology fungal metabolism. Penicillium sclerotiorum SD-36 was isolated from cucumbers our previous study. Genome sequencing results indicate that this strain harbors as many 52 BGCs, suggesting it holds wealth genetic resources essential synthesizing diverse SMs. Here, we describe impact class 1 histone deacetylase (HDAC), PsHos2, on metabolism SD-36. colony morphology SM profile ΔPsHos2 exhibited significant changes, emergence multiple new compound peaks. Six compounds, including five azaphilones, which are characterized by pyranoquinone core structure, were ΔPsHos2, seventeen unreported azaphilone-related nodes obtained using molecular networking based LC-MS/MS. Transcriptome analysis revealed PsHos2 influenced expression 44 BGC genes. Specifically, seven genes within cluster 86.1, putative upregulated, two polyketide synthase (PKS) regulation HDACs is an important strategy enhancing synthesis fungi expanding

Language: Английский

Citations

0
Regulation of Histone Acetylation Modification on Biosynthesis of Secondary Metabolites in Fungi DOI Open Access

Xuwen Hou,

Liyao Liu,

Yu Li

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 25 - 25

Published: Dec. 24, 2024

The histone acetylation modification is a conservative post-translational epigenetic regulation in fungi. It includes and deacetylation at the lysine residues of histone, which are catalyzed by acetyltransferase (HAT) deacetylase (HDAC), respectively. plays crucial roles fungal growth development, environmental stress response, secondary metabolite (SM) biosynthesis, pathogenicity. One most important to regulate gene expression that responsible for SM biosynthesis This mini-review summarized HATs HDACs on SMs In cases, positively regulated SMs, while had their negative regulations. Some were revealed biosynthesis. Hda1 was found be efficient regulator affect species mainly from genera Aspergillus, Calcarisporium, Cladosporium, Fusarium, Monascus, Penicillium, Pestalotiopsis. With strategy modification, some harmful will inhibited, production useful bioactive promoted subsequent research should focus study regulatory mechanisms.

Language: Английский

Citations

2
Epigenetic modulation of fungal pathogens: a focus on Magnaporthe oryzae DOI Creative Commons
Hafiz Muhammad Usman Aslam, Mohamad Chikh-Ali, Xin‐Gen Zhou

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 28, 2024

Epigenetics has emerged as a potent field of study for understanding the factors influencing effectiveness human disease treatments and identifying alternations induced by pathogens in host plants. However, there been paucity research on epigenetic control proliferation pathogenicity fungal plant pathogens. Fungal such Magnaporthe oryzae , significant threat to global rice production, provide an important model exploring how mechanisms govern virulence. In M. alterations, DNA methylation, histone modification, non-coding RNAs, regulate gene expression patterns that influence pathogen’s ability infect its host. These modifications can enhance adaptability, allowing pathogen survive diverse environments evade immune responses. Our primary objective is comprehensive review existing shed light these changes lifecycle, invade tissues, overall severity disease. We begin examining alterations occurring their contributions virulence fungus. To advance our similar diseases, we emphasize need address unanswered questions explore future directions. This information crucial developing new antifungal target pathways, which could lead improved management.

Language: Английский

Citations

1