Genomic Evolution and Phylodynamics of the Species Orthomarburgvirus marburgense (Marburg and Ravn Viruses) to Understand Viral Adaptation and Marburg Virus Disease’s Transmission Dynamics DOI Creative Commons
Claude Mambo Muvunyi, Nouh Saad Mohamed, Emmanuel Edwar Siddig

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(12), P. 1107 - 1107

Published: Dec. 14, 2024

In this review, we investigated the genetic diversity and evolutionary dynamics of Orthomarburgvirus marburgense species that includes both Marburg virus (MARV) Ravn (RAVV). Using sequence data from natural reservoir hosts human cases reported during outbreaks, conducted comprehensive analyses to explore variability, constructing haplotype networks at genome gene levels elucidate viral pathways. Our results revealed distinct trajectories for MARV RAVV, with exhibiting higher adaptability across different ecological regions. showed substantial evidence varied pressures, suggesting an ability adapt diverse environments. contrast, RAVV demonstrated limited diversity, no detected recombination events, stability. These differences indicate that, while continues diversify regions, may be constrained in its potential, possibly reflecting differing roles within ecology species. analysis explains mechanisms these viruses, highlighting is going through adaptation human-to-human transmission, alarmingly underscoring global concern about causing next pandemic. However, further transdisciplinary One Health research warranted answer some remaining questions including host range susceptibility domestic wildlife as well role biodiversity network disease’s dynamics.

Language: Английский

A diagnostic challenge of tongue botryomycosis miming mycetoma—A case report DOI Creative Commons
Emmanuel Edwar Siddig, Ayman Ahmed

Skin Health and Disease, Journal Year: 2024, Volume and Issue: 4(5)

Published: Aug. 5, 2024

Abstract Botryomycosis of the tongue is a rare chronic bacterial infection that presents as nodular masses, mimicking other infectious or neoplastic conditions such mycetoma. A case an 80‐year‐old male was presented with painless swelling on right lateral side his to outpatient clinic. Biopsy and microbiological investigations revealed unexpected Staphylococcus aureus ‐related botryomycosis. This highlights diagnostic challenge for unusual clinical presentations infections. Healthcare providers in countries endemic diseases manifest similarly should investigate thoroughly ensure positive outcome through early diagnosis effective management.

Language: Английский

Citations

3
Genomic Evolution and Phylodynamics of the Species Orthomarburgvirus marburgense (Marburg and Ravn Viruses) to Understand Viral Adaptation and Marburg Virus Disease’s Transmission Dynamics DOI Creative Commons
Claude Mambo Muvunyi, Nouh Saad Mohamed, Emmanuel Edwar Siddig

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(12), P. 1107 - 1107

Published: Dec. 14, 2024

In this review, we investigated the genetic diversity and evolutionary dynamics of Orthomarburgvirus marburgense species that includes both Marburg virus (MARV) Ravn (RAVV). Using sequence data from natural reservoir hosts human cases reported during outbreaks, conducted comprehensive analyses to explore variability, constructing haplotype networks at genome gene levels elucidate viral pathways. Our results revealed distinct trajectories for MARV RAVV, with exhibiting higher adaptability across different ecological regions. showed substantial evidence varied pressures, suggesting an ability adapt diverse environments. contrast, RAVV demonstrated limited diversity, no detected recombination events, stability. These differences indicate that, while continues diversify regions, may be constrained in its potential, possibly reflecting differing roles within ecology species. analysis explains mechanisms these viruses, highlighting is going through adaptation human-to-human transmission, alarmingly underscoring global concern about causing next pandemic. However, further transdisciplinary One Health research warranted answer some remaining questions including host range susceptibility domestic wildlife as well role biodiversity network disease’s dynamics.

Language: Английский

Citations

2