Molluscicide screening and identification of novel targets against Pomacea canaliculata DOI

Guoli Qu,

Jiakai Yao,

Jie Wang

et al.

Pest Management Science, Journal Year: 2024, Volume and Issue: 80(9), P. 4264 - 4272

Published: April 16, 2024

Abstract BACKGROUND Owing to the nonavailability of any clear targets for molluscicides against Pomacea canaliculata , target‐based screening strategy cannot be employed. In this study, molluscicidal effects typical pesticides on P. were evaluated obtain molluscicide target. A series arylpyrrole compounds synthesized based discovered target, and their structure–activity relationships explored. preliminary specific was also developed. RESULTS laboratory colony developed, which showed no difference in sensitivity niclosamide compared with wild group, while exhibiting a higher stability pesticide response. Mitochondrial adenosine triphosphate (ATP) synthase inhibitors mitochondrial membrane potential uncouplers identified validated as . designed synthesized. The median lethal concentration 4‐bromo‐2‐(4‐chlorophenyl)‐5‐(trifluoromethyl)‐1H‐pyrrole‐3‐carbonitrile (Compound 102) 10‐fold lower than that niclosamide. CONCLUSION New validated, strategies explored these targets. Compound 102 exhibited high activity had great value exploring control © 2024 Society Chemical Industry.

Language: Английский

Fungal biofilms in human health and disease DOI
Gordon Ramage, Ryan Kean, Riina Rautemaa‐Richardson

et al.

Nature Reviews Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

Citations

1
An overview to drug repurposing DOI

Khushal Khambhati,

Abdulrahman H. Alessa, Vijai Singh

et al.

Progress in molecular biology and translational science, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 8

Published: Jan. 1, 2024

Language: Английский

Citations

4
Current approaches in identification of a novel drug targets for drug repurposing DOI

Khushal Khambhati,

Vijai Singh

Progress in molecular biology and translational science, Journal Year: 2024, Volume and Issue: unknown, P. 213 - 220

Published: Jan. 1, 2024

Language: Английский

Citations

1
Molluscicide screening and identification of novel targets against Pomacea canaliculata DOI

Guoli Qu,

Jiakai Yao,

Jie Wang

et al.

Pest Management Science, Journal Year: 2024, Volume and Issue: 80(9), P. 4264 - 4272

Published: April 16, 2024

Abstract BACKGROUND Owing to the nonavailability of any clear targets for molluscicides against Pomacea canaliculata , target‐based screening strategy cannot be employed. In this study, molluscicidal effects typical pesticides on P. were evaluated obtain molluscicide target. A series arylpyrrole compounds synthesized based discovered target, and their structure–activity relationships explored. preliminary specific was also developed. RESULTS laboratory colony developed, which showed no difference in sensitivity niclosamide compared with wild group, while exhibiting a higher stability pesticide response. Mitochondrial adenosine triphosphate (ATP) synthase inhibitors mitochondrial membrane potential uncouplers identified validated as . designed synthesized. The median lethal concentration 4‐bromo‐2‐(4‐chlorophenyl)‐5‐(trifluoromethyl)‐1H‐pyrrole‐3‐carbonitrile (Compound 102) 10‐fold lower than that niclosamide. CONCLUSION New validated, strategies explored these targets. Compound 102 exhibited high activity had great value exploring control © 2024 Society Chemical Industry.

Language: Английский

Citations

1