Lubrication for Osteoarthritis: From Single-Function to Multifunctional Lubricants
Wen Chen,
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Qianwen Ye,
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Mingshuo Zhang
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et al.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 1856 - 1856
Published: Feb. 21, 2025
Osteoarthritis
(OA)
is
a
common
degenerative
joint
disease
that
progressively
destroys
articular
cartilage,
leading
to
increased
friction
and
severe
pain.
Therefore,
OA
can
be
treated
by
restoring
the
lubricating
properties
of
cartilage.
In
this
study,
recent
advances
in
lubricants
for
treatment
are
reviewed
both
single-function
multifunctional
lubricants.
Single-function
mainly
include
glycosaminoglycans,
lubricin,
phospholipids,
whereas
composed
anti-inflammatory
bifunctional
hydrogels,
stem
cell-loaded
drug-loaded
nanoparticles.
This
review
emphasizes
importance
lubrication
capacity
explores
structural
features,
properties,
role
these
modulating
intracellular
inflammatory
responses
metabolism.
Current
challenges
future
research
directions
field
also
discussed,
with
aim
providing
scientific
basis
new
ideas
clinical
OA.
Language: Английский
Bioinspired Design and Applications of Liquid Gating Gas Valve Membranes
Yuxiu Li,
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Junyang Liu,
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Rui Xu
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et al.
Biomimetics,
Journal Year:
2025,
Volume and Issue:
10(2), P. 77 - 77
Published: Jan. 26, 2025
In
nature,
dynamic
liquid
interfaces
play
a
vital
role
in
regulating
gas
transport,
as
exemplified
by
the
adaptive
mechanisms
of
plant
stomata
and
liquid-lined
alveoli,
which
enable
efficient
exchange
through
reversible
opening
closing.
These
biological
processes
provide
profound
insights
into
design
advanced
control
technologies.
Inspired
these
natural
systems,
gating
membranes
have
been
developed
utilizing
capillary-stabilized
liquids
to
achieve
precise
fluid
regulation.
offer
unique
advantages
rapid
responses,
stain
resistance,
high
energy
efficiency.
Particularly,
they
break
limitations
traditional
solid,
porous
transport.
This
perspective
introduces
bioinspired
valve
(LGVMs),
emphasizing
their
opening/closing
mechanism.
It
highlights
how
external
stimuli
can
be
exploited
advanced,
multi-level
active
or
passive
regulation
strategies.
Diverse
applications
flow
selective
transport
are
discussed.
While
challenges
related
controllability,
long-term
stability,
scalable
production
persist,
advancements
unlock
significant
opportunities
for
groundbreaking
innovations
across
diverse
fields,
including
purification,
microfluidics,
medical
diagnostics,
harvesting
Language: Английский
Phospholipids and Sphingolipids in Osteoarthritis
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(2), P. 250 - 250
Published: Feb. 8, 2025
Many
studies
now
emphasize
the
intricate
relationship
between
lipid
metabolism
and
osteoarthritis
(OA),
a
leading
cause
of
disability.
This
narrative
review
examines
alterations
in
levels
phospholipids
(PLs)
sphingolipids
(SLs)
synovial
fluid
(SF),
plasma,
serum,
articular
tissues;
discusses
their
role
joint
lubrication,
inflammation,
cartilage
degradation;
describes
potential
as
diagnostic
markers
therapeutic
targets.
Key
findings
include
stage-dependent
elevated
specific
PLs
SLs
SF,
blood,
tissue
OA
patients,
implicating
them
possible
biomarkers
disease
severity
progression.
Studies
suggest
that
beyond
involvement
these
lipids
individual
species,
such
lysophosphatidylcholine
(LPC)
16:0,
lysophosphatidic
acid
(LPA),
ceramide-1-phosphate
(C1P),
sphingosine-1-phosphate
(S1P),
contribute
to
pain,
degradation
joints
through
various
signaling
pathways.
Cross-species
comparisons
dogs
mice
experience
similar
lipidomic
changes
during
humans,
rendering
valuable
models
for
studying
lipid-related
mechanisms.
SF
appear
originate
primarily
from
blood
capillaries
diffusion.
In
addition,
are
produced
locally
by
fibroblast-like
synoviocytes
(FLSs)
influenced
cytokines
growth
factors
regulate
biosynthesis
lubrication.
Emerging
research
has
identified
genes
UGCG
ESYT1
regulators
OA.
Further,
we
examine
suitability
targeting
PL
SL
pathways
treat
OA,
emphasizing
need
further
translate
into
clinical
applications.
Language: Английский
RNA therapies for musculoskeletal conditions
Journal of Controlled Release,
Journal Year:
2024,
Volume and Issue:
377, P. 756 - 766
Published: Dec. 4, 2024
Language: Английский
Recent Advances in Biomimetic Related Lubrication
Jinqiang Shao,
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Guiyao Lan,
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Haoxin Song
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et al.
Lubricants,
Journal Year:
2024,
Volume and Issue:
12(11), P. 377 - 377
Published: Oct. 30, 2024
Friction
is
ubiquitous
in
industry
and
daily
life,
which
not
only
leads
to
the
wear
tear
of
equipment
machinery,
but
also
causes
a
lot
energy
waste.
one
significant
factors
leading
loss
mechanical
systems.
Therefore,
it
essential
minimize
friction
losses.
Creatures
nature
have
evolved
various
surfaces
with
different
tribological
characteristics
adapt
environment.
By
studying,
understanding,
summarizing
lubrication
regulation
phenomena
typical
nature,
bionic
theories
methods
are
obtained
guide
development
new
materials
This
article
primarily
discusses
study
mechanisms
through
biomimetic
design,
mainly
divided
into
chemical
approaches,
structural
strategies,
chemical–structural
coupling
approaches.
From
point
view,
this
paper
summarizes
joint
engineering
biomedicine,
inspiration
from
lotus
leaves,
fish
skin,
snake
each
unique
antifriction
structures
famous
for
their
super
hydrophobicity
nature.
Finally,
simulates
mechanism
natural
organisms
action
biological
substances,
applied
coating
so
as
reduce
on
surfaces,
improve
durability
anti-pollution
ability
coatings,
significantly
performance
systems,
promote
scientific
innovation,
conservation,
emission
reduction,
sustainable
development.
Language: Английский