Frailty in asthma-COPD overlap: a cross-sectional study of association and risk factors in the NHANES database

BMJ Open Respiratory Research, Journal Year: 2023, Volume and Issue: 10(1), P. e001713 - e001713

Published: June 1, 2023

Background Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a condition characterised by the simultaneous presence of features both asthma and COPD. The study aims to investigate association between ACO frailty among middle-aged elderly populations, identify risk factors for in individuals with ACO. Methods We conducted cross-sectional 34 403 eligible participants (aged ≥40 years) from National Health Nutrition Examination Survey 1999–2018 cycles. Participants were stratified into four groups: ACO, asthma, COPD non-asthma/COPD. Frailty assessment was based on index, generating frail non-frail group. Univariate multivariate survey-weighted logistic regression analysis used determine frailty, Results prevalence 60.2%, significantly higher than that those (32.3%) (40.6%). In unadjusted model, exhibited six-fold odds (OR 6.30, 95% CI 5.29 7.49), which greater 2.84, 2.46 3.28) 1.99, 1.80 2.18), using non-asthma/COPD group as reference. After adjusting all confounders, had over times 4.48, 3.53 5.71), still findings remained robust sensitivity subgroup analyses. Furthermore, hypertension, cancer, cardiovascular disease, chronic kidney cognitive disorders identified participants, while income education levels protective factors. Conclusion Patients at regardless age or sex, compared alone. Greater attention should be paid patients their age.

Language: Английский

---

Modulating asthma–COPD overlap responses with IL-17 inhibition

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 27, 2023

IL-17 is a modulator of the inflammatory response and implicated in lung remodeling both asthma chronic obstructive pulmonary disease (COPD). Well as probably patients with asthma-COPD overlap (ACO). In this study, we evaluated airways alveolar septa to anti-IL-17 treatment an ACO model. Fifty-six male BALB/c mice were sensitized ovalbumin (OVA group), received porcine pancreatic elastase (PPE or (ACO group). Mice then treated either monoclonal antibody saline. We hyperresponsiveness, bronchoalveolar lavage fluid (BALF) cell counts, mean diameter. quantified inflammatory, response, extracellular matrix remodeling, oxidative stress markers, signaling pathway markers. Anti-IL-17 group reduced maximum respiratory system Rrs, Ers, Raw, Gtis, when compared (p<0.05). There was reduction total number cells, neutrophils, macrophages BALF attenuated dendritic CD4+, CD8+, FOXP3, IL-1β, IL-2, IL-6, IL-13, IL-17, IL-33 airway septum observed MMP-9, MMP-12, TIMP-1, TGF-β, collagen type I (p < 0.05). also iNOS 8-iso-PGF2α anti-IL-17group Regarding pathways, NF-kB, ROCK-1, ROCK-2 Our results suggest that inhibiting modulates cell-associated cytokine production tissue, through modulation NF-kB FOXP3.

Language: Английский

---

Distinct physiological, transcriptomic, and imaging characteristics of asthma-COPD overlap compared to asthma and COPD in smokers

EBioMedicine, Journal Year: 2024, Volume and Issue: 110, P. 105453 - 105453

Published: Nov. 23, 2024

Language: Английский

---

A comparison of treatment response to biologics in asthma-COPD overlap and pure asthma: Findings from the PRISM study

World Allergy Organization Journal, Journal Year: 2023, Volume and Issue: 16(12), P. 100848 - 100848

Published: Dec. 1, 2023

Despite the increasing use of biologics in severe asthma, there is limited research on their asthma-chronic obstructive pulmonary disease overlap (ACO). We compared real-world treatment responses to ACO and asthma. conducted a multicenter, retrospective, cohort study using data from Precision Medicine Intervention Severe Asthma (PRISM). was defined as post-bronchodilator forced expiratory volume 1 s (FEV1)/forced vital capacity (FVC) <0.7 smoking history >10 pack-years. Physicians selected (omalizumab, mepolizumab, reslizumab, benralizumab, dupilumab) based each United States Food & Drug Administration (FDA) approval criteria. After six-month with biologics, both patients (N = 13) asthma 81) showed positive FEV1 (10.69 ± 17.17 vs. 11.25 12.87 %, P 0.652), Control Test score (3.33 5.47 5.39 5.42, 0.290), oral corticosteroid (-117.50 94.38 -115.06 456.85 mg, 0.688), fractional exhaled nitric oxide levels (-18.62 24.68 -14.66 45.35 ppb, 0.415), sputum eosinophils (-3.40 10.60 -14.48 24.01 0.065), blood (-36.47 517.02 -363.22 1294.59, 0.013), exacerbation frequency (-3.07 4.42 -3.19 5.11, 0.943). The odds ratio for time-to-first no significant difference after full adjustments, subgroup analysis according biologic type also similar results. Biologics response patterns were comparable, suggesting that should be actively considered well.

Language: Английский

---

Digital methylation-specific PCR: New applications for liquid biopsy

BioMolecular Concepts, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 1, 2024

Abstract Epigenetic analysis is a fundamental part of understanding pathophysiological processes with potential applications in diagnosis, prognosis, and assessment disease susceptibility. changes have been widely studied chronic obstructive pulmonary (COPD), but currently, there no molecular marker used to improve the treatment patients. Furthermore, this progressive risk factor for development more severe COVID-19. Methylation-specific polymerase chain reaction (MSP-PCR) plays an important role DNA methylation profiles, it one most techniques. In context, combination MSP-PCR emerging PCR technologies, such as digital (dPCR), results accurate analyses profile genes under study. study, we propose application MSP-dPCR technique evaluate ADAM33 gene from saliva samples lung tissue biopsies patients COPD generated measurable prediction rate, combined technology diagnostic prognostic purposes. It has also proven be powerful tool liquid biopsy applications.

Language: Английский

---

Spirometry test values can be estimated from a single chest radiograph

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: March 6, 2024

Physical measurements of expiratory flow volume and speed can be obtained using spirometry. These have been used for the diagnosis risk assessment chronic obstructive pulmonary disease play a crucial role in delivering early care. However, spirometry is not performed frequently routine clinical practice, thereby hindering detection function impairment. Chest radiographs (CXRs), though acquired frequently, are to measure functional information. This study aimed evaluate whether parameters estimated accurately from single frontal CXR without image findings deep learning.

Language: Английский

---

Associations of sugary beverage consumption with chronic obstructive pulmonary disease, asthma, and asthma–chronic obstructive pulmonary disease overlap syndrome: a prospective cohort study

American Journal of Clinical Nutrition, Journal Year: 2024, Volume and Issue: 120(3), P. 707 - 718

Published: July 4, 2024

Language: Английский

---

Relationships between oxidative balance score and asthma, COPD, with asthma-COPD overlap in American adults: Findings from NHANES 2013-2018

Journal of Asthma, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: Oct. 25, 2024

Background Oxidative stress plays a crucial role in the development of multiple chronic respiratory diseases. Balance Score (OBS) composing 16 dietary factors and 4 lifestyle has been developed to evaluate effect oxidants/antioxidants produced by intake habits on overall oxidative balance. However, relationships between OBS with asthma, COPD, asthma-COPD overlap (ACO) are still unclear.

Language: Английский

---

Air quality self-management in asthmatic patients with COPD: An integrative review for developing nursing interventions to prevent exacerbations

International Journal of Nursing Sciences, Journal Year: 2023, Volume and Issue: 11(1), P. 46 - 56

Published: Dec. 12, 2023

Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) patients experience a lower quality of life, frequent exacerbations, and worse function. Environmental management is essential in complex chronic condition, as pollutant exposure can worsen symptoms increase morbidity mortality. We aimed to identify evidence that informs nursing interventions promoting self-management air asthmatic people with COPD.

Language: Английский

---

COPD Patients with Asthma Features in Vietnam: Prevalence and Suitability for Personalized Medicine

Journal of Personalized Medicine, Journal Year: 2023, Volume and Issue: 13(6), P. 901 - 901

Published: May 26, 2023

COPD patients with asthma features usually benefit from inhaled corticosteroids (ICS)-containing regimens, but their burden and diagnostic criteria remain to be established. The aims of this study were estimate the proportion among physician-diagnosed investigate differences in clinical characteristics current medications between alone. A cross-sectional was conducted at two respiratory out-patient clinics University Medical Center Ho Chi Minh City Bach Mai Hospital Ha Noi, Vietnam. identified by attending physicians following approach recommended GINA/GOLD joint committee. Of 332 screened, 300 enrolled study. 27.3% (95% confidence interval CI) 22.6-32.6%). younger, higher FEV1 values, a greater positive bronchodilator reversibility tests, blood eosinophil count, more often treated ICS/LABA (ICS/long-acting beta-2 agonist) than prevalence is particularly high Vietnam thus requiring appropriate action plans practice.

Language: Английский

---