Revue des Maladies Respiratoires, Journal Year: 2022, Volume and Issue: 39(8), P. 685 - 697
Published: Aug. 30, 2022
Language: Английский
Open Life Sciences, Journal Year: 2023, Volume and Issue: 18(1)
Published: Jan. 1, 2023
Chronic obstructive pulmonary disease (COPD) and asthma are common airway diseases, there similarities differences between them. Serum eosinophil (EOS) has potential application value in the diagnosis, treatment, prognosis of COPD asthma. However, clinical serum EOS these two diseases is controversial. In this work, recent research progress on was analyzed, expounded from several aspects, including correlation pathogenesis EOS, as well EOS. The results revealed that important pathogenesis, exhibited a value. further study needed to evaluate threshold, which provided guidance for diagnosis treatment
Language: Английский
Citations
2
Annals of the American Thoracic Society, Journal Year: 2024, Volume and Issue: 21(8), P. 1166 - 1175
Published: May 15, 2024
Rationale: Asthma poses a significant burden for U.S. patients and health systems, yet inpatient care quality is understudied. National chronic obstructive lung disease (COPD) readmission policies may affect asthma through hospital responses to these because of imprecise diagnosis identification with COPD asthma. Objectives: Evaluate hospitalized potential collateral effects the Medicare Hospital Readmissions Reduction Program (HRRP). Methods: This was retrospective cohort study aged 18-54 years across 924 hospitals (Premier Healthcare Database). Results: Care evaluated before HRRP implementation (n = 20,820; January 2010-September 2014) after 26,885; October 2014-December 2018) using adherence guidelines (recommended, nonrecommended, "ideal care" [all recommended no nonrecommended care]). Between 2010 2018, at least 80% received annually. Recommended decreased similarly (rate 0.02%/mo) versus (P 0.8). Nonrecommended more rapidly 0.29%/mo) 0.17%/mo; P < 0.001), changes driven largely by antibiotic prescribing. Ideal increased 0.25%/mo) 0.02), improvements. Conclusions: Post-HRRP trends suggest improved rates guideline concordance in ideal care. Although federal (e.g., HRRP) have had positive effects, such as care, parallel efforts, including stewardship, likely contributed
Language: Английский
Citations
0
Revista Colombiana de Neumología, Journal Year: 2024, Volume and Issue: 35(2Supl-1)
Published: June 7, 2024
Introducción: La enfermedad pulmonar obstructiva crónica (EPOC) constituye un importante desafío tanto en el ámbito económico como de la salud pública, a nivel mundial contexto colombiano. Esta condición no solo repercute los pacientes que padecen, sino también afecta sus cuidadores y al sistema su conjunto. Se ha observado incremento ausentismo laboral por parte familiares, lo resulta pérdidas económicas oportunidades laborales, agravando aún más impacto adverso individuo entorno familiar. El propósito esta guía clínica es establecer pautas basadas evidencia científica disponible para mejorar atención médica gestión recursos tratamiento EPOC población colombiana. Objetivo: práctica (GPC) informada Asociación Colombiana Neumología Cirugía Tórax (Asoneumocito), Medicina Interna (ACMI) colombiana medicina familiar (SOCMEF) Fisioterapia (ASCOFI), pretende apoyar pacientes, profesionales salud, otros actores toma decisiones sobre diagnostico, enfoque, pronóstico manejo adultos con Materiales métodos: Comité Asoneumocito delegación presidencia esta, conformó panel expertos multidisciplinario balancear minimizar potencial sesgo proveniente conflictos intereses e invitó las demás asociaciones hicieron guía. Universidad Andes coordinó desarrolló actualización o realización novo revisiones sistemáticas literatura acorde metodología GRADE (Grading of Recommendations Assessment, Development and Evaluation). comité planteó una serie preguntas priorizó, así desenlaces según importancia pacientes. utilizaron marcos Evidencia Decisión (EtD) desarrollados grupo trabajo GRADE, cuales estuvieron sujetos comentarios públicos. Resultados: elaboró 10 recomendaciones recibieron alguna siguientes intervenciones: oxigenoterapia largo plazo, vacunación contra virus influenza, rehabilitación pulmonar, inhaloterapia anticolinérgicos acción prolongada, terapia triple, suplementos nutricionales, complementaria azitromicina, cesación tabáquica vareniclina reemplazo alfa-1 antitripsina. Conclusiones: Las incluidas se desarrollaron consideró hacen falta desarrollar estudios evaluaciones económicas, intervenciones evaluadas áreas equidad, aceptabilidad factibilidad implementación Colombia.
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The Indian Journal of Chest Diseases and Allied Sciences, Journal Year: 2024, Volume and Issue: 66(3), P. 85 - 88
Published: Nov. 19, 2024
Language: Английский
Citations
0
Published: Aug. 22, 2024
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Pulmonary Therapy, Journal Year: 2024, Volume and Issue: 11(1), P. 7 - 24
Published: Dec. 11, 2024
The latest advances in asthma treatment have highlighted the significance of eosinophilia and possible role some pro-eosinophilic mediators, like interleukins (IL) IL-5, IL-4/IL-13, IL-33 disease's pathogenesis. Considering that a subgroup patients with chronic obstructive pulmonary disease (COPD) may blood akin to seen asthma, numerous studies last decade suggested eosinophilic COPD is separate entity. While exact eosinophils pathophysiology remains unclear, seems increase effectiveness corticosteroid therapy. Currently, monoclonal antibodies targeting (IL-5, IL-4, IL-13, IL-33) or their receptors are being investigated belonging T2-high endotype. This review focuses on mechanisms COPD, effects outcome, examines most recent data use peripheral treating COPD. Finally, we emphasize current implication context airway inflammation.
Language: Английский
Citations
0
Revue des Maladies Respiratoires, Journal Year: 2023, Volume and Issue: 41(2), P. 127 - 138
Published: Dec. 20, 2023
Language: Английский
Citations
1
European journal of medical research, Journal Year: 2022, Volume and Issue: 27(1)
Published: Oct. 28, 2022
Little is known about the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD) overlap (ACO). This study examined molecular phenotypes ACO in elderly.A genome-wide investigation gene expression sputum cells from elderly with asthma, ACO, or COPD was performed using set variation analysis (GSVA) predefined asthma- COPD-specific signatures. We then a subsequent cluster enrichment scores (ESs) to identify clusters ACO. Finally, second GSVA conducted curated signatures gain insight into associated identified clusters.Seventy individuals were enrolled (17 41 12 COPD). Two distinct identified. Clinically, 1 (N = 23) characterized by male smoker dominance, more lung function, higher proportions both neutrophil eosinophil induced compared 2 18). had features similar COPD, mitochondria peroxisome dysfunction as important mechanisms these diseases. The differed those enhanced innate immune reactions microorganisms being this form ACO.Recognition unique biological pathways two will deepen our understanding elderly.
Language: Английский
Citations
2
Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(11), P. 1853 - 1853
Published: Nov. 6, 2022
Asthma is a heterogeneous disease of the airways with high prevalence worldwide characterized by chronic inflammation [...].
Language: Английский
Citations
2
Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation, Journal Year: 2022, Volume and Issue: unknown, P. 477 - 485
Published: Jan. 1, 2022
Balkissoon R, Mkorombindo T. Journal club: impaired ventilatory efficiency and exercise intolerance in former/current smokers with dyspnea disproportionate to their lung function: pathophysiological insights gained through cardiopulmonary testing.
Language: Английский
Citations
1