Pathological Effects of COVID-19 on Body Organs DOI Creative Commons

Sabereh Ahmadzadeh,

Mehrnoosh Sedighi,

Amin Torkashvand

et al.

Journal of Medical Microbiology and Infectious Diseases, Journal Year: 2023, Volume and Issue: 11(1), P. 1 - 19

Published: March 1, 2023

The SARS-COV-2 virus is the cause of 2020 pandemic that has infected and killed millions worldwide.While upper respiratory tract cells are primary targets COVID-19, can infiltrate other tissues organs, leading to potentially serious complications.The new coronavirus primarily affects angiotensin II receptor cytokine pathways, which result in acute pulmonary inflammation, edema, distress syndrome, vascular endothelial dysfunction, embolism lungs, cardiomyopathy, arrhythmia, heart failure, intravenous thrombosis heart.COVID-19 infection be associated with gastrointestinal symptoms such as diarrhea, vomiting, abdominal pain.Also, reports mild transient liver damage, polyneuropathy, encephalitis, stroke, renal hypocortisolism, damage hypothalamus pituitary system available.COVID-19 also skin rash, urticaria, maculopapular lesions, lesions chill blain, petechiae purpura, scalpopathy.This narrative review evaluates pathogenesis novel on body organs based relevant published papers reference books. Vol. 11 No. 1The incubation period 2-14 days after enters [6][7].The prevalence slightly higher men than women.After period, most people have clinical moderate illness, fever, dry cough, fatigue, muscle aches, shortness breath.Most them cared for at home without particular treatment protocols.Older underlying diseases, cardiovascular disease, high blood pressure, diabetes, obesity, chronic or cancer, typically more susceptible a severe form virus.Clinical patients include breath, pain pressure chest, bruising lips face [7][8][9].Complications pneumonia, hypoxia, shock, multiple organ thromboembolism, bleeding, myopathy lead extended hospitalization fatal outcomes.Laboratory results these show Erythrocyte Sedimentation Rate (ESR), D-dimer level, lymphocyte reduction (lymphocytopenia) peripheral sample [7][8][9][10].The infecting mechanism lung heart.These causes death rates patients.This aims evaluate organs. METHODThis paper discusses impact some vital molecular mechanisms involved this disease 184 articles available various online databases Web Science, Scopus, Pubmed, books.However, different COVID-19 strains affect body's summarized Table 1.Table 1.COVID-19 Variants Being Monitored (VBM) WHO Label Pango

Language: Английский

Spatial and Temporal Analysis of SARS-CoV-2 Genome Evolutionary Patterns DOI Open Access
Shubhangi Gupta, Deepanshu Gupta, Sonika Bhatnagar

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 21, 2023

ABSTRACT The spread of SARS-CoV-2 virus accompanied by availability abundant sequence data publicly, provides a window for determining the spatio-temporal patterns viral evolution in response to vaccination. In this study, genome sequences were collected from seven countries period January 2020-December 2022. classified into three phases, namely: pre-vaccination, post-vaccination, and recent period. Comparison was performed between these phases based on parameters like mutation rates, selection pressure (dN/dS ratio), transition transversion ratios (Ti/Tv). Similar comparisons among variants. Statistical significance tested using Graphpad unpaired t-test. comparative analysis showed an increase percent genomic rates post-vaccination periods across different pre-vaccination phase. dN/dS positive that increased after vaccination, Ti/Tv decreased C→U G→U most frequent transitions transversions all countries. However, U→G Omicron variant had highest while Delta ratio. Mutation NSP3, S, N NSP12b before further NSP4 largest change N, ORF8, ORF3a ORF10 under They overtaken E, S NSP1 vaccination as well sequences, with observed NSP1. Protein-wise ratio also seen vary Importance Irrespective vaccine technologies used, geographical regions host genetics, variations have maintained similar worldwide. To best our knowledge, there exists no other large-scale study protein-wise during time course Analysing spatial, temporal, biological signals is important diagnostics, therapeutics, pharmacovigilance SARS-CoV-2.

Language: Английский

Citations

0
Pathological Effects of COVID-19 on Body Organs DOI Creative Commons

Sabereh Ahmadzadeh,

Mehrnoosh Sedighi,

Amin Torkashvand

et al.

Journal of Medical Microbiology and Infectious Diseases, Journal Year: 2023, Volume and Issue: 11(1), P. 1 - 19

Published: March 1, 2023

The SARS-COV-2 virus is the cause of 2020 pandemic that has infected and killed millions worldwide.While upper respiratory tract cells are primary targets COVID-19, can infiltrate other tissues organs, leading to potentially serious complications.The new coronavirus primarily affects angiotensin II receptor cytokine pathways, which result in acute pulmonary inflammation, edema, distress syndrome, vascular endothelial dysfunction, embolism lungs, cardiomyopathy, arrhythmia, heart failure, intravenous thrombosis heart.COVID-19 infection be associated with gastrointestinal symptoms such as diarrhea, vomiting, abdominal pain.Also, reports mild transient liver damage, polyneuropathy, encephalitis, stroke, renal hypocortisolism, damage hypothalamus pituitary system available.COVID-19 also skin rash, urticaria, maculopapular lesions, lesions chill blain, petechiae purpura, scalpopathy.This narrative review evaluates pathogenesis novel on body organs based relevant published papers reference books. Vol. 11 No. 1The incubation period 2-14 days after enters [6][7].The prevalence slightly higher men than women.After period, most people have clinical moderate illness, fever, dry cough, fatigue, muscle aches, shortness breath.Most them cared for at home without particular treatment protocols.Older underlying diseases, cardiovascular disease, high blood pressure, diabetes, obesity, chronic or cancer, typically more susceptible a severe form virus.Clinical patients include breath, pain pressure chest, bruising lips face [7][8][9].Complications pneumonia, hypoxia, shock, multiple organ thromboembolism, bleeding, myopathy lead extended hospitalization fatal outcomes.Laboratory results these show Erythrocyte Sedimentation Rate (ESR), D-dimer level, lymphocyte reduction (lymphocytopenia) peripheral sample [7][8][9][10].The infecting mechanism lung heart.These causes death rates patients.This aims evaluate organs. METHODThis paper discusses impact some vital molecular mechanisms involved this disease 184 articles available various online databases Web Science, Scopus, Pubmed, books.However, different COVID-19 strains affect body's summarized Table 1.Table 1.COVID-19 Variants Being Monitored (VBM) WHO Label Pango

Language: Английский

Citations

0