Molecular Medicine Reports, Journal Year: 2024, Volume and Issue: 30(3)

Published: July 3, 2024

DNA methylation is one of the earliest and most significant epigenetic mechanisms discovered. refers, in general, to addition a methyl group specific base sequence under catalysis methyltransferase, with S‑adenosine methionine as donor, via covalent bonding chemical modifications. an important factor inducing cancer. There are different types methylation, at sites plays roles. It well known that progression colorectal cancer (CRC) affected by key genes. The present review did not only discuss potential relationship between CRC but also discussed how affects development affecting Furthermore, clinical significance was highlighted, including therapeutic targets biomarkers methylation; importance inhibitors novel strategy for treatment CRC. focus upon latest research findings, earlier reviews were cited references older literature.

Language: Английский