A Comparative Analysis of Liver Injury Markers in Post-COVID Syndrome among Elderly Patients: A Prospective Study

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(4), P. 1149 - 1149

Published: Feb. 18, 2024

In the wake of global COVID-19 pandemic, understanding its prolonged impact on vulnerable populations has become a critical area investigation. This study aimed to elucidate distinctive post-acute sequelae SARS-CoV-2 infection (PASC) and liver injury in Romania's elderly population, hypothesizing unique demographic, clinical, healthcare factors influencing manifestation. A longitudinal design was employed, enrolling patients from Victor Babes Hospital for Infectious Diseases Pulmonology Timisoara, Romania. Participants were stratified into three groups based age Long COVID status. The focused variety biological parameters, including function tests, assess trajectory severity over six months post discharge. Involving 238 participants, revealed significant increase duration hospitalization those 65 (15.8 ± 8.2 days) compared younger (p < 0.001). Notably, exhibited marked elevation enzymes discharge, with median ΔALT ΔAST 24.1 U/L 30.2 U/L, respectively, suggesting ongoing Significant metabolic disruptions observed, ΔFasting glucose showing substantial decrease 21.1 mmol/L group pronounced reduction ΔGGT (16.7 U/L) ΔLDH (48.7 noted, indicating recovery reduced tissue damage Coagulation profiles fibrosis risk scores, particularly ΔFIB-4 ΔAPRI, also significantly improved complications. confirms hypothesis more severe PASC among Romanian population. improvements discharge suggest degree recovery, yet persistent alterations enzymes, metabolism, scores call continued monitoring tailored management strategies.

Language: Английский

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Comorbidities and Severe COVID-19 Outcomes: A Retrospective Analysis of Hospitalized Patients in Three Counties in Romania

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 787 - 787

Published: March 29, 2025

Background: The COVID-19 pandemic represents a major global health crisis, with clinical manifestations ranging from asymptomatic infection to fatal outcomes. While all individuals are susceptible, specific populations, particularly those pre-existing medical conditions, face heightened risk of severe disease. This study aimed assess the prevalence among hospitalized patients comorbidities in Central Region Romania, and analyze association between these conditions mortality. Methods: We conducted retrospective cohort using data Corona Forms platform (2020–2022), encompassing cases across three Romanian counties. A total 1458 confirmed SARS-CoV-2 documented were included. Demographic characteristics, comorbid hospitalization outcomes analyzed. Results: overall mortality rate was 89.3%. Renal, neurologic, hepatic disease, cardiovascular obesity, type 2 diabetes mellitus, cerebrovascular accidents significant factors for death SARS-CoV-2-infected population. strength their varies, odds ratios 25.32 1. Conclusions: findings underscore critical impact on severity population, emphasizing necessity targeted interventions public strategies protect high-risk populations.

Language: Английский

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The link between the fatal cases with SARS-CoV-2 infection and multimorbidity: Our single institution experience

Acta Marisiensis. Seria Medica, Journal Year: 2025, Volume and Issue: 71(1), P. 31 - 39

Published: March 1, 2025

Abstract Objective During the pandemic, SARS-CoV-2 infection with its different variants had determined high morbidity and mortality. As clinical autopsies were reduced in our country, complete forensic provided important valuable information regarding pathological changes pathophysiological mechanisms associated infection. Our aim was to focus on of SARS-CoV-2, trying determine contribution lethal outcome establish cause death. Methods Complete performed cases confirmed by polymerase chain reaction for All findings patient’s comorbidities analyzed. Results Forty-nine studied. Twenty female (41%), 29 male (59%). The median age at death 63 years (range 26-93 years), an upward trend during four SARS-CoV-2. that died due their SARS-Cov-2 higher compared Two thirds hospital, most them less than one week hospitalization third found dead home. Most without significant health conditions Conclusions immediate many respiratory origin diffuse alveolar damage. evident represented, highlight importance multimorbidity development critical illness.

Language: Английский

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Factors Associated with All-Cause 30-Day Mortality in Indonesian Inpatient COVID-19 Patients at Cipto Mangunkusumo National General Hospital

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(10), P. 2998 - 2998

Published: May 20, 2024

Introduction: Indonesia, as a developing country, has limited data on the factors associated with 30-day mortality in COVID-19 patients Indonesia. As matter of fact, study analyzing infection Indonesia never been conducted. This aims to fill this gap literature by conducting large-scale analysis Method: employed single-center retrospective cohort observational design, and was conducted at Cipto Mangunkusumo National General Hospital between years 2022 2023. Sampling using consecutive sampling method. The included aged 18 above who had confirmed have infection. Survival Kaplan-Meier multivariate Cox regression analysis. Result: Our total 644 patients, 120 (18.6%) expiring within 30 days. In backward Wald method, severe (HR: 7.024; 95% CI: 3.971-12.744; p value: <0.0001), moderate 1.660; 1.048-2.629; 0.031), liver cirrhosis 3.422; 1.208-9.691; 0.021), female sex 1.738; 1.187-2.545; 0.004), old age 2.139; 1.279-3.577; high leukocyte 11.502; 1.523-86.874; 0.018), NLR 1.720; 1.049-2.819; 0.032), CRP 1.906; 1.092-3.329; 0.023), procalcitonin 3.281; 1.780-6.049; 0.001), creatinine 1.863; 1.240-2.800; 0.003) were from Subgroup excluding cancer showed that age, D-Dimer, CRP, PCT while steroid therapy is protective. Conclusions: finds severity, cirrhosis, sex, leukocyte, NLR, creatinine, These findings underscore multifactorial nature mortality. It important, therefore, which exhibit these should be treated more aggressively prevent

Language: Английский

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Predicting Severe COVID-19 Outcomes in the Elderly: The Role of Systemic Immune Inflammation, Liver Function Tests, and Neutrophil-to-Lymphocyte Ratio

Healthcare, Journal Year: 2024, Volume and Issue: 12(23), P. 2429 - 2429

Published: Dec. 3, 2024

: Patients aged 80 years and above are at increased risk for severe COVID-19 outcomes. This study aimed to evaluate the prognostic utility of derived neutrophil-to-lymphocyte ratio (dNLR), aspartate-aminotransferase-to-lymphocyte index (ALRI), aspartate-aminotransferase-to-platelet (APRI), systemic immune inflammation (SII) in predicting disease, intensive care unit (ICU) admission, mortality among patients older.

Language: Английский

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