Cytokine Expression and Cytolytic Effect of Natural Killer Cells are Suppressed in Septic Shock
Fengying Jie,
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Fang Dong,
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Lingwen Xu
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et al.
Scandinavian Journal of Immunology,
Journal Year:
2025,
Volume and Issue:
101(4)
Published: April 1, 2025
ABSTRACT
Septic
shock
is
the
most
severe
stage
of
sepsis.
How
immune
dysregulation
contributes
to
pathogenesis
septic
has
not
been
thoroughly
understood.
In
current
research,
phenotype
and
function
circulating
natural
killer
(NK)
cells
patients
were
characterised.
The
absolute
number
NK
was
comparably
reduced
in
survivors
non‐survivors,
probably
owing
elevated
cell
apoptosis.
Activating
receptors
including
signalling
lymphocytic
activation
molecule
4
(SLAMF4),
p30‐related
protein
(NKp30),
group
2,
member
D
(NKG2D),
DNAX
accessory
1
(DNAM‐1)
significantly
downregulated
on
surface
patients,
especially
non‐survivors.
Furthermore,
patients'
exhibited
lower
expression
granzyme
B
perforin,
weaker
target
cell‐induced
degranulation
cytokine
expression,
as
well
incompetent
cytolytic
effect.
These
alterations
more
profound
Importantly,
serum
interleukin‐35
(IL‐35),
which
an
immunosuppressive
cytokine,
remarkably
patients.
Besides,
concentration
positively
correlated
with
disease
scores
but
negatively
activating
receptor
expression.
vitro
assays
indicated
IL‐35‐induced
strong
suppression
activity,
evidenced
by
concomitant
downregulation
cytokines
along
inhibition
capacity.
Therefore,
we
uncovered
for
first
time
contributing
role
IL‐35
shock‐related
human
dysfunction.
Language: Английский
Optimizing Mean Arterial Pressure Targets for Septic Shock Patients With Chronic Hypertension: A Narrative Review
Mutaz I. Othman,
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Emad Mustafa,
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Amir AbdelWahab
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et al.
Health Science Reports,
Journal Year:
2025,
Volume and Issue:
8(5)
Published: May 1, 2025
ABSTRACT
Background
and
Aims
Septic
shock
is
a
serious
infection‐related
condition
that
has
big
effect
on
public
health.
To
improve
organ
perfusion
prognosis
in
septic
patients
with
chronic
high
blood
pressure,
optimal
mean
arterial
pressure
(MAP)
targets
are
needed.
This
narrative
review
aims
to
summarize
existing
knowledge
factors
determine
the
most
effective
MAP
hypertension.
Methods
A
careful
of
relevant
literature
was
conducted
understand
affect
Long‐term
hypertension
require
personalized
based
age,
health
conditions,
severity.
Results
five
studies
were
identified
this
review.
Guidelines
suggest
65‐75
mmHg
for
cases,
but
higher
may
be
beneficial
proper
perfusion.
Continuous
hemodynamic
monitoring
allows
dynamic
adjustment
targets.
Conclusion
It
crucial
implement
management
strategies
achieve
outcomes
who
experiencing
shock.
However,
there
lack
consensus
among
hypertension,
which
maintain
adequate
tissue
An
approach
considers
each
patient's
unique
characteristics
includes
ongoing
assessment
critical
achieving
best
improving
patient
prognosis.
Language: Английский