Effects of Low-Intensity Transcranial Magnetic Stimulation in Neuropsychological Development of Pediatric Subjects With Autism Spectrum Disorder: A Longitudinal Retrospective Approach DOI Open Access

T Mendoza,

Alan R Oviedo Lara,

Gabriel Henk Jordan

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 29, 2024

Autism spectrum disorder (ASD) is a heterogeneous neurobiological condition characterized by behavioral problems and delayed neurodevelopment. Although transcranial magnetic stimulation (TMS) has been proposed as an alternative treatment for patients with ASD because of its promising benefits in reducing repetitive behaviors enhancing executive functions, the use high-intensity pulses (Hi-TMS) appears to be related side effects therapy. Low-intensity TMS (Li-TMS) partially investigated, but it may have clinical on simultaneously increase safety. In this study, combined intervention Li-TMS conventional therapies were evaluated 35 from Ecuador (six female 29 male), aged between three seven years, confirmed diagnosis ASD. Each subject received twice week (for four weeks) provided at research center (psychological, occupational, speech, neuro-psychomotor therapies) alongside daily sessions 1 Hz 9 mT intensity targeting left dorsolateral prefrontal cortex (L-DLPFC) 45 min weeks (16 total). The Battelle Developmental Inventory (BDI), first edition, was applied before after therapy evaluate subjects Weekly follow-up assessments parent questionnaires administered identify any adverse events. all BDI domains, significant statistical difference observed pre- post-intervention averages, supported extremely low p-values (less than 0.001 cases). personal, social, motor, cognitive, communicative skills study participants increased At same time, calculated maturational delay had decrease, suggesting improvement ~7.78 months neurodevelopment subjects. However, age also found possible cause these changes development maturation. No observed. Both variants TMS, Hi-TMS Li-TMS, proven treatments ASD, improving social cognitive abilities. This investigation suggests that combination 16 individuals progress, specifically maturation according BDI. addition, low-intensity fields allow safer pulse delivery pediatric subjects, no reported study.

Language: Английский

Effects of Low-Intensity Transcranial Magnetic Stimulation in Neuropsychological Development of Pediatric Subjects With Autism Spectrum Disorder: A Longitudinal Retrospective Approach DOI Open Access

T Mendoza,

Alan R Oviedo Lara,

Gabriel Henk Jordan

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 29, 2024

Autism spectrum disorder (ASD) is a heterogeneous neurobiological condition characterized by behavioral problems and delayed neurodevelopment. Although transcranial magnetic stimulation (TMS) has been proposed as an alternative treatment for patients with ASD because of its promising benefits in reducing repetitive behaviors enhancing executive functions, the use high-intensity pulses (Hi-TMS) appears to be related side effects therapy. Low-intensity TMS (Li-TMS) partially investigated, but it may have clinical on simultaneously increase safety. In this study, combined intervention Li-TMS conventional therapies were evaluated 35 from Ecuador (six female 29 male), aged between three seven years, confirmed diagnosis ASD. Each subject received twice week (for four weeks) provided at research center (psychological, occupational, speech, neuro-psychomotor therapies) alongside daily sessions 1 Hz 9 mT intensity targeting left dorsolateral prefrontal cortex (L-DLPFC) 45 min weeks (16 total). The Battelle Developmental Inventory (BDI), first edition, was applied before after therapy evaluate subjects Weekly follow-up assessments parent questionnaires administered identify any adverse events. all BDI domains, significant statistical difference observed pre- post-intervention averages, supported extremely low p-values (less than 0.001 cases). personal, social, motor, cognitive, communicative skills study participants increased At same time, calculated maturational delay had decrease, suggesting improvement ~7.78 months neurodevelopment subjects. However, age also found possible cause these changes development maturation. No observed. Both variants TMS, Hi-TMS Li-TMS, proven treatments ASD, improving social cognitive abilities. This investigation suggests that combination 16 individuals progress, specifically maturation according BDI. addition, low-intensity fields allow safer pulse delivery pediatric subjects, no reported study.

Language: Английский

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