Nutrients,
Journal Year:
2022,
Volume and Issue:
15(1), P. 200 - 200
Published: Dec. 30, 2022
Bisphenol
A
(BPA),
commonly
used
as
a
plasticizer
in
various
branches
of
industry
has
strong
negative
effect
on
living
organisms.
Therefore,
more
and
often
it
is
replaced
production
plastics
by
other
substances.
One
them
bisphenol
S
(BPS).
This
study
for
the
first
time
compares
impact
BPA
BPS
enteric
neurons
using
double
immunofluorescence
technique.
It
been
shown
that
both
affect
number
containing
substance
P
(SP),
galanin
(GAL),
vasoactive
intestinal
polypeptide
(VIP),
neuronal
isoform
nitric
oxide
synthase
(nNOS-a
marker
nitrergic
neurons)
and/or
vesicular
acetylcholine
transporter
(VAChT-
cholinergic
neurons).
The
changes
noted
under
bisphenols
are
similar
consisted
an
increase
immunoreactive
to
all
factors
studied.
some
populations
was
stronger
than
influence
BPA.
obtained
results
clearly
show
(similarly
BPA)
administered
long
not
neutral
even
relatively
low
doses
may
be
potent
certain
populations.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(5), P. 4585 - 4585
Published: Feb. 26, 2023
Bisphenol
A
(BPA)
is
a
phenolic
compound
used
in
plastics
elaboration
for
food
protection
or
packaging.
BPA-monomers
can
be
released
into
the
chain,
resulting
continuous
and
ubiquitous
low-dose
human
exposure.
This
exposure
during
prenatal
development
especially
critical
could
lead
to
alterations
ontogeny
of
tissues
increasing
risk
developing
diseases
adulthood.
The
aim
was
evaluate
whether
BPA
administration
(0.036
mg/kg
b.w./day
3.42
b.w./day)
pregnant
rats
induce
liver
injury
by
generating
oxidative
stress,
inflammation
apoptosis,
these
effects
may
observed
female
postnatal
day-6
(PND6)
offspring.
Antioxidant
enzymes
(CAT,
SOD,
GR,
GPx
GST),
glutathione
system
(GSH/GSSG)
lipid-DNA
damage
markers
(MDA,
LPO,
NO,
8-OHdG)
were
measured
using
colorimetric
methods.
Inducers
stress
(HO-1d,
iNOS,
eNOS),
(IL-1β)
apoptosis
(AIF,
BAX,
Bcl-2
BCL-XL)
qRT-PCR
Western
blotting
lactating
dams
Hepatic
serum
histology
performed.
Low
dose
caused
had
perinatal
effect
PND6
offspring
levels,
triggering
an
inflammatory
response
pathways
organ
responsible
detoxification
this
endocrine
disruptor.
Journal of Hazardous Materials,
Journal Year:
2024,
Volume and Issue:
476, P. 135053 - 135053
Published: June 27, 2024
The
presence
of
microplastics
in
cosmetics
and
personal
care
products
(C&PCPs)
has
been
increasingly
the
public
eye
since
early
2010s.
Despite
increasing
research
into
potential
environmental
health
effects
microplastics,
most
to
date
on
C&PCPs
investigated
"rinse-off"
products,
while
impacts
"leave-on"
have
largely
neglected,
despite
these
being
purchased
greater
volumes
often
having
two
or
more
microplastic
ingredients
their
formulations(CosmeticsEurope,
2018b).
This
review
aims
synthesize
current
knowledge
C&PCPs,
assessing
human
discussing
regulatory
implications.
lack
studies
leave-on
is
significant,
suggesting
a
severe
gap
regarding
in,
emissions
from,
C&PCPs.
There
noticeable
(eco)toxicological
consequences
exposure
from
As
result,
significant
aspects
contamination
may
be
overlooked
legislations
emerging
globally
(including
European
Commission),
which
intend
restrict
use
but
focus
rinse-off
only.
highlights
for
decision-making,
particularly
as
alternatives
are
considered
during
phase-out
periods
spotlights
need
sufficient
monitoring
alternatives,
avoid
unforeseen
consequences.
Frontiers in Toxicology,
Journal Year:
2021,
Volume and Issue:
3
Published: Sept. 29, 2021
Humans
are
exposed
to
micro
and
nanoplastics
(MNPLs)
through
inhalation,
ingestion
and,
a
lesser
extent,
dermal
contact.
In
recent
years,
new
insights
indicate
the
potential
of
MNPLs
cause
damages
human
health.
Particle
toxicity
can
include
oxidative
stress,
inflammatory
lesions,
then
increased
internalization
or
translocation
tissues.
On
other
hand,
plastic
additives
used
in
particles,
once
internalized,
release
toxic
substances.
It
is
noteworthy
that
effects
encompass
wide
range
polymers
chemical
additives,
showing
various
physicochemical
toxicological
properties,
size,
shape
surface
properties
variables
influencing
their
effects.
spite
research
carried
out
recently,
its
early
stages,
further
investigation
required.
this
review
article,
knowledge
exposure
routes
results
on
health
presented
discussed.
Finally,
current
limitations
main
gaps
body
summarised.
Frontiers in Reproductive Health,
Journal Year:
2023,
Volume and Issue:
5
Published: Aug. 2, 2023
Bisphenol
F
(BPF),
an
alternative
to
bisphenol
A
has
been
implicated
as
a
gonadotoxic
substance.
BPF
shown
induce
hormonal
imbalance
and
testicular
oxidative
damage.
However,
the
mechanism
associated
with
BPF-induced
toxicity
not
fully
explored.
This
study
was
designed
explore
role
of
tumor
protein
(p53)/
B-cell
lymphoma
2
(BCl-2)
signaling
oestrogen
receptor
beta
(Erβ)
in
toxicity.Male
Wistar
rats
were
randomized
into
control
(Cntrl),
BPF-treated
(10,
30,
50
mg/kg
for
low
dose
(BPF-L),
medium
(BPF-M),
high
(BPF-H)
respectively),
recovery
(Cntrl-R,
BPF-L-R,
BPF-M-R,
BPF-H-R).
The
administration
via
gavage
lasted
28
days
animals
groups
allowed
28-days
exposure
free
period
from
exposure.BPF
resulted
distortion
histoarchitecture,
which
accompanied
by
significant
rise
gamma-lutamyl
transferase
lactate
dehydrogenase
activities
but
decline
sorbitol
activities.
Also,
caused
reduction
plasma
gonadotropin-releasing
hormone,
luteinising
follicle-stimulating
testosterone,
downregulation
3beta-hydroxysteroid
17beta-hydroxysteroid
Furthermore,
induced
inflammation,
redox
imbalance,
apoptosis,
p53/BCl-2
overexpression
Erβ.
Again,
observed
toxic
effects
dose-dependent
completely
reversed
cessation.Bisphenol
gonadotoxicity
distorting
p53/BCl2
expression
These
alterations
after
cessation
exposure.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(10), P. 11386 - 11400
Published: May 9, 2024
The
Mn–Co
dual-metal
oxide
is
recognized
as
an
effective
activator
for
peroxymonosulfate
(PMS),
but
its
activation
mechanism
remains
controversial.
In
this
study,
a
Co/Mn–C–N
(CMCN)
nanocatalyst
was
synthesized
using
simple
pyrolysis
method,
and
catalytic
activity
along
with
the
PMS
comprehensively
explored.
findings
indicated
that
synergistic
effect
of
Mn
Co
within
bimetallic
composition
significantly
enhanced
efficiency
CMCN
compared
to
those
individual
metal
oxides
(Mn–C–N
Co–C–N).
Bisphenol
A
underwent
successful
degradation
3
min
in
neutral
environment,
kinetic
rate
1.59
min–1
total
organic
carbon
removal
63.8%.
Moreover,
nanoparticles
demonstrated
remarkable
stability
reusability,
maintaining
their
efficacy
over
four
cycles.
Employing
series
experiments
analytical
characterizations,
novel
proposed,
involving
both
radical
nonradical
pathways.
This
involves
oxidation
pollutants
through
direct
electron
transfer
process
from
metastable
intermediate
complexes.
Notably,
CMCN/PMS
system
exhibited
robust
resistance
interference
factors.
research
provides
insights
into
development
composites
recalcitrant
water
pollutants.
Ecotoxicology and Environmental Safety,
Journal Year:
2022,
Volume and Issue:
244, P. 114079 - 114079
Published: Sept. 15, 2022
This
study
investigated
the
effect
of
BPF
on
male
sexual
performance
and
quality
offspring.
Eighty
(80)
Male
Wistar
rats
(n
=
10
per
group)
were
randomised
into
normal
saline-treated
control
recovery,
varied
doses
(low,
medium,
high),
recovery
high)
groups.
The
was
terminated
after
28
days
oral
administration.
animals
sacrificed
24
h
from
last
dose,
while
those
in
groups
allowed
to
recover
for
another
before
being
sacrificed.
administration
found
impair
performance,
as
shown
by
a
significant
decrease
frequencies
(mount,
intromission,
ejaculation
frequencies)
an
increase
latencies
latencies).
accompanied
plasma
LH,
FSH,
testosterone,
dopamine,
acetylcholinesterase,
nitric
oxide,
penile
cyclic
guanosine
monophosphate
(cGMP)
level.
level
oestrogen
prolactin
significantly
increased
following
also
reduced
sperm
count,
morphology,
viability,
motility.
Furthermore,
fertility
success
index,
litter
size,
weight,
offspring
survival
rate.
These
toxic
effects
dose-dependent
not
reversed
withdrawal
recovery.
concluded
that
disrupts
competence
suppressing
hypothalamic-pituitary-gonadal
axis
mediating
oestrogen-induced
hyperprolactinemia.
events
associated
with
index
success,
poor
semen
quality,
observed
cessation
exposure.
