Russian Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
92(10), P. RCR5095 - RCR5095
Published: Aug. 28, 2023
Mitochondrial
dysfunctions
lead
to
the
emergence
and
development
of
a
large
number
diseases.
The
present
review
gives
first
systematic
survey
various
aspects
studies
mitochondria-targeted
nanosystems
containing
triphenylphosphonium
vector
groups
providing
targeted
delivery
drug
substances
these
organelles.
Approaches
design
components
nanoparticles
bearing
are
summarized
analyzed.
relationship
between
key
parameters
(chemical
composition,
size,
shape,
ζ-potential,
loading,
encapsulation
efficiency,
<i>etc</i>.)
biological
action
is
discussed;
in
some
cases,
mechanism
mitochondria
targeting
given.
principles
preparation
methods
for
interest
researchers
field
nanomaterials,
nanotechnology,
molecular
biology,
biotechnology
pharmaceutical
chemistry.
<br>
bibliography
includes
243
references.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(9), P. 8209 - 8209
Published: May 3, 2023
Cardiovascular
disease
(CVD)
frequently
complicates
chronic
kidney
(CKD).
The
risk
of
all-cause
mortality
increases
from
20%
to
500%
in
patients
who
suffer
both
conditions;
this
is
referred
as
the
so-called
cardio-renal
syndrome
(CRS).
Preclinical
studies
have
described
key
role
mitochondrial
dysfunction
cardiovascular
and
renal
diseases,
suggesting
that
maintaining
homeostasis
a
promising
therapeutic
strategy
for
CRS.
In
review,
we
explore
malfunction
(mitochondrial
biogenesis,
dynamics,
oxidative
stress,
mitophagy)
how
it
contributes
development
progression
main
vascular
pathologies
could
be
affected
by
injury
vice
versa,
knowledge
may
guide
novel
strategies
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4981 - 4981
Published: May 2, 2024
We
are
living
in
an
era
of
advanced
nanoscience
and
nanotechnology.
Numerous
nanomaterials,
culminating
nanorobots,
have
demonstrated
ingenious
applications
biomedicine,
including
breast
cancer
(BC)
nano-theranostics.
To
solve
the
complicated
problem
BC
heterogeneity,
non-targeted
drug
distribution,
invasive
diagnostics
or
surgery,
resistance
to
classic
onco-therapies
real-time
monitoring
tumors,
nanorobots
designed
perform
multiple
tasks
at
a
small
scale,
even
organelles
molecular
level.
Over
last
few
years,
most
been
bioengineered
as
biomimetic
biocompatible
nano(bio)structures,
resembling
different
organisms
cells,
such
urchin,
spider,
octopus,
fish,
spermatozoon,
flagellar
bacterium
helicoidal
cyanobacterium.
In
this
review,
readers
will
be
able
deepen
their
knowledge
structure,
behavior
role
several
types
among
other
theranostics.
summarized
here
characteristics
many
functionalized
nanodevices
counteract
main
neoplastic
hallmark
features
BC,
from
sustaining
proliferation
evading
anti-growth
signaling
resisting
programmed
cell
death
inducing
angiogenesis,
activating
invasion
metastasis,
preventing
genomic
instability,
avoiding
immune
destruction
deregulating
autophagy.
Most
these
function
targeted
self-propelled
smart
nano-carriers
nano-drug
delivery
systems
(nano-DDSs),
enhancing
efficiency
safety
chemo-,
radio-
photodynamic
therapy,
current
imagistic
techniques
used
diagnosis.
tested
vitro,
using
various
lines,
well
vivo,
mainly
based
on
mice
models.
still
waiting
for
that
low-cost,
wider
transition
favorable
effects
laboratory
clinical
practice.
Cancer Biology and Medicine,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 14
Published: July 9, 2024
Gastric
cancer
(GC)
ranks
fifth
in
incidence
and
fourth
cancer-related
mortality
worldwide.
Reactive
oxygen
species
(ROS)
are
highly
oxidative
oxygen-derived
products
that
have
crucial
roles
cell
signaling
regulation
maintaining
internal
balance.
ROS
closely
associated
with
the
occurrence,
development,
treatment
of
GC.
This
review
summarizes
recent
findings
on
sources
bidirectional
regulatory
effects
GC
discusses
various
modalities
for
related
to
induction.
In
addition,
by
natural
small
molecule
compounds
highest
potential
development
applications
anti-GC
research
is
summarized.
The
aim
accelerate
clinical
application
modulating
levels
as
a
therapeutic
strategy
Russian Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
92(10), P. RCR5095 - RCR5095
Published: Aug. 28, 2023
Mitochondrial
dysfunctions
lead
to
the
emergence
and
development
of
a
large
number
diseases.
The
present
review
gives
first
systematic
survey
various
aspects
studies
mitochondria-targeted
nanosystems
containing
triphenylphosphonium
vector
groups
providing
targeted
delivery
drug
substances
these
organelles.
Approaches
design
components
nanoparticles
bearing
are
summarized
analyzed.
relationship
between
key
parameters
(chemical
composition,
size,
shape,
ζ-potential,
loading,
encapsulation
efficiency,
<i>etc</i>.)
biological
action
is
discussed;
in
some
cases,
mechanism
mitochondria
targeting
given.
principles
preparation
methods
for
interest
researchers
field
nanomaterials,
nanotechnology,
molecular
biology,
biotechnology
pharmaceutical
chemistry.
<br>
bibliography
includes
243
references.
