The use of inhibition assay in Api g 7 suspected allergy in a female patient with anaphylaxis: A case report

International Journal of Immunopathology and Pharmacology, Journal Year: 2024, Volume and Issue: 38

Published: Jan. 1, 2024

The symptoms of celery allergy are mainly presented as oral symptom, but there several case reports patients who experienced anaphylaxis. Defensin (Api g 7), a novel allergen in root, was described 2022 r. female patient had history episodes dyspnea and cough, associated with ingestion spice mixes containing dried celery. Up to the point hospitalization, were no objective tests, either sIgE or skin prick that would confirm sensitization. During positive double-blind placebo-controlled food challenge cooked sensitized mugwort defensin Art v 1. An inhibition assay extract performed prove cross-sensitization between 1 responsible for patient. In conclusion, Api 7 is an important can be severe reactions. Its cross-reactivity characteristic. Negative diagnostic tests do not exclude

Language: Английский

A systematic review reveals conflicting evidence for the prevalence of antibodies against the sialic acid ‘xenoautoantigen’ Neu5Gc in humans and the need for a standardised approach to quantification

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: April 26, 2024

Despite an array of hypothesised implications for health, disease, and therapeutic development, antibodies against the non-human sialic acid N-glycolylneuraminic (Neu5Gc) remain a subject much debate. This systematic review 114 publications aimed to generate comprehensive overview published studies in this field, addressing both reported prevalence anti-Neu5Gc human population whether experimental variation accounts conflicting reports about extent response. Absolute titres antibodies, these individual observed within experiments were analysed grouped according biological context ('inflammation', 'xenotransplantation', 'biotherapeutic use', 'cancer', 'healthy populations'), detection method, target epitope selection, choice blocking agent. These analyses revealed that method had notable impact on absolute general population, thereby limiting ability ascribe trends genuine differences or consequence design. Overall, highlights important knowledge gaps study xenoautoantigen need establish standardised their quantification if importance Neu5Gc health is be fully understood.

Language: Английский