The use of inhibition assay in Api g 7 suspected allergy in a female patient with anaphylaxis: A case report
International Journal of Immunopathology and Pharmacology,
Journal Year:
2024,
Volume and Issue:
38
Published: Jan. 1, 2024
The
symptoms
of
celery
allergy
are
mainly
presented
as
oral
symptom,
but
there
several
case
reports
patients
who
experienced
anaphylaxis.
Defensin
(Api
g
7),
a
novel
allergen
in
root,
was
described
2022
r.
female
patient
had
history
episodes
dyspnea
and
cough,
associated
with
ingestion
spice
mixes
containing
dried
celery.
Up
to
the
point
hospitalization,
were
no
objective
tests,
either
sIgE
or
skin
prick
that
would
confirm
sensitization.
During
positive
double-blind
placebo-controlled
food
challenge
cooked
sensitized
mugwort
defensin
Art
v
1.
An
inhibition
assay
extract
performed
prove
cross-sensitization
between
1
responsible
for
patient.
In
conclusion,
Api
7
is
an
important
can
be
severe
reactions.
Its
cross-reactivity
characteristic.
Negative
diagnostic
tests
do
not
exclude
Language: Английский
A systematic review reveals conflicting evidence for the prevalence of antibodies against the sialic acid ‘xenoautoantigen’ Neu5Gc in humans and the need for a standardised approach to quantification
Esme Hutton,
No information about this author
Emma Scott,
No information about this author
Craig Robson
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et al.
Frontiers in Molecular Biosciences,
Journal Year:
2024,
Volume and Issue:
11
Published: April 26, 2024
Despite
an
array
of
hypothesised
implications
for
health,
disease,
and
therapeutic
development,
antibodies
against
the
non-human
sialic
acid
N-glycolylneuraminic
(Neu5Gc)
remain
a
subject
much
debate.
This
systematic
review
114
publications
aimed
to
generate
comprehensive
overview
published
studies
in
this
field,
addressing
both
reported
prevalence
anti-Neu5Gc
human
population
whether
experimental
variation
accounts
conflicting
reports
about
extent
response.
Absolute
titres
antibodies,
these
individual
observed
within
experiments
were
analysed
grouped
according
biological
context
('inflammation',
'xenotransplantation',
'biotherapeutic
use',
'cancer',
'healthy
populations'),
detection
method,
target
epitope
selection,
choice
blocking
agent.
These
analyses
revealed
that
method
had
notable
impact
on
absolute
general
population,
thereby
limiting
ability
ascribe
trends
genuine
differences
or
consequence
design.
Overall,
highlights
important
knowledge
gaps
study
xenoautoantigen
need
establish
standardised
their
quantification
if
importance
Neu5Gc
health
is
be
fully
understood.
Language: Английский