Mild hypothermia alleviates cardiomyocyte necroptosis after cardiopulmonary resuscitation by regulating TRPV1 DOI Creative Commons

Meixian Yin,

Chuiliang Liu,

Yifan Zhu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Abstract Background Therapeutic mild hypothermia (MH) is expected to improve the neurological outcome and survival rate of CPR after cardiac arrest (CA). However, mechanisms by which MH protects cardiomyocytes remain largely unexplored. Methods In this study, three- four-month-old male Wistar rats, weighing between 319.1 480.0 grams, were randomly divided into normothermia (NT) groups (acceptable range, 36.0-38.0°C) 32-34°C). Ten minutes CA, was perfumed with a slow injection 0.30-0.50 mL epinephrine solution (30.00 μg/mL). Moreover, investigate role TRPV1, capsaicin administered through right femoral artery in both NT groups. Results We found that improved spontaneous breathing recovery, increased rate, inhibited necroptosis rats CPR. Additionally, alleviated primary oxygen-glucose deprivation reperfusion upregulating downregulating EGFR, subsequently suppressing MLKL. Furthermore, combination capsaicin, TRPV1 activator, enhanced blood pressure compared alone. Capsaicin Conclusions may protect function mitigating cardiomyocyte regulating TRPV1.

Language: Английский

Phytoconstituents with cardioprotective properties: A pharmacological overview on their efficacy against myocardial infarction DOI
Aman Ullah, Nada M. Mostafa, Sobia Ahsan Halim

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(9), P. 4467 - 4501

Published: July 18, 2024

Myocardial infarction (MI) is considered one of the most common cardiac diseases and major cause death worldwide. The prevalence MI MI-associated mortality have been increasing in recent years due to poor lifestyle habits viz. residency, obesity, stress, pollution. Synthetic drugs for treatment provide good chance survival; however, demand search more safe, effective, natural increasing. Plants fruitful sources powerful antioxidant anti-inflammatory agents prevention and/or MI. However, many plant extracts lack exact information about their possible dosage, toxicity drug interactions which may hinder usefulness as potential options. Phytoconstituents play cardioprotective role by either acting a prophylactic or adjuvant therapy concurrently used synthetic decrease dosage relief side effects such drugs. This review highlights different herbal formulations, examples types several isolated phytoconstituents (phenolic acids, flavonoids, stilbenes, alkaloids, phenyl propanoids) with reported activities. Moreover, mechanisms action are also discussed guide future research development safer substitutes manage

Language: Английский

Citations

4
Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights DOI Creative Commons
Ankit Verma, Tarique Anwer,

Muzaffar Iqbal

et al.

Open Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

Abstract Purpose The aim of this research study is to assess the ability quercetin protect heart from negative consequences tacrolimus-induced cardiotoxicity. Methods A total 30 rats were divided into 5 groups. Tacrolimus was used induce cardiotoxicity, whereas employed as a protective agent. Results administration significantly raised levels serum cardiac biomarkers (Lactate dehydrogenase, creatine kinase-myocardial band, and troponin-I) well inflammatory (tumor necrosis alpha interleukin 6). reduced significantly. In addition, treatment with tacrolimus resulted in higher malondialdehyde (MDA) (lipid peroxidation marker) falling glutathione (GSH) antioxidant enzymes such superoxide dismutase (SOD), reductase (GR), catalase (CAT). Quercetin MDA increased GSH enzyme (SOD, GR, CAT) levels. Moreover, tacrolimus-administered group exhibited histological changes tissue cited vacuole formation, large uncondensed nucleus, cardiomyocyte hypertrophy. cell infiltration thus formation Conclusions outcome showed quercetin’s cardioprotective potential against Consequently, it concluded that may be add-on therapy reduce adverse effects.

Language: Английский

Citations

0
Chrysin Mitigates Cyclophosphamide-triggered Cardiotoxicity in Rats: Insights into Cardioprotection via Treg Expression Modulation and iNOS Downregulation DOI Creative Commons
Dalia O. Saleh, Marawan A. Elbaset, Kawkab A. Ahmed

et al.

Toxicology Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102007 - 102007

Published: March 1, 2025

Language: Английский

Citations

0
New insights into the potential cardioprotective effects of telmisartan and nanoformulated extract of Spirulina platensis via regulation of oxidative stress, apoptosis, and autophagy in an experimental model DOI Creative Commons

May Almukainzi,

Thanaa A. El‐Masry,

Hanaa A Ibrahim

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 9, 2024

Graphical Abstract

Language: Английский

Citations

2
Bioactive extract of Morchella esculenta ameliorates cyclophosphamide-induced mitochondrial dysfunction and cardiotoxicity by modulating KEAP1/NRF2 and pro-inflammatory genes expression DOI
Sneha Das, Thekkuttuparambil Ananthanarayanan Ajith, K. K. Janardhanan

et al.

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 191, P. 114847 - 114847

Published: July 2, 2024

Language: Английский

Citations

2
The Impact of Metformin on the Development of Hypothyroidism and Cardiotoxicity Induced by Cyclophosphamide, Methotrexate, and Fluorouracil in Rats DOI Creative Commons
Ahmad Alhowail, Maha A. Aldubayan

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(9), P. 1312 - 1312

Published: Sept. 16, 2023

Cyclophosphamide (CYP), methotrexate (MTX), and 5-fluorouracil (5-FU) are extensively utilized in the therapeutic management of various malignancies. It is noteworthy, however, that potential chemotherapy-related complications include occurrence hypothyroidism cardiotoxicity. Metformin (MET) a pharmacological agent for managing type 2 diabetes. has been reported to mitigate certain toxic manifestations associated with chemotherapy. This study's primary objective investigate MET's protective effects against cardiotoxicity induced by CMF treatment. A total forty male rats were allocated into four distinct groups, each consisting ten per group. These groups categorized as follows: saline, MET, CMF, + MET. The experimental group administered via intraperitoneal injection, receiving two doses fed MET their daily drinking water, 2.5 mg/mL concentration. Blood samples collected EDTA tubes assessment TSH, free (T4 T3), troponin I, CK, CK-MB levels utilizing Electrochemiluminescence Immunoassays (ECI). saline did not exhibit significant alterations thyroid hormones or cardiotoxic biomarkers. In contrast, group, there was notable reduction T4, FT4, T3, FT3 but no changes TSH levels; notably elevated. co-treatment ameliorate these caused CMF. conclusion, treatment rats, rescue elevation

Language: Английский

Citations

2
Effects of rosmarinic acid on cyclophosphamide-induced nephrotoxicity in rats DOI Open Access
Dilan ÇETİNAVCI, Engin Yeni̇lmez, Ayşe Firuze Bıyık

et al.

Çukurova medical journal (Online)/Çukurova medical journal, Journal Year: 2023, Volume and Issue: 48(3), P. 902 - 910

Published: Sept. 25, 2023

Purpose: Cyclophosphamide (CP) is an antineoplastic agent. It used in the treatment of many types cancer. Rosmarinic acid (RA) exhibits remarkable biological activities such as anti-inflammatory, antitumor, antibacterial, and antimicrobial effects. This study aimed to evaluate effect rosmarinic against CP-induced nephrotoxicity. Materials Methods: Eighteen male Sprague Dawley rats were randomly divided into 3 equal groups; Sham group (n=6): 0.9% saline solution/8 days/oral gavage + solution/8th day/intraperitoneal, CP 200 mg/kg/8th day/intraperitoneal CP, CP+RA 100 mg/kg/8 RA was applied. Hematoxylin Eosin, Periodic Acid-Schiff, Masson’s Trichrome staining performed on collected tissues Results: Histopathological evaluation revealed tubular atrophy, glomerular damage, vascular congestion, vacuolization, interstitial inflammation group. scores significantly lower compared Intertubular fibrosis observed Fibrosis decreased with acid. PAS-stained sections from showed epithelial brush border, basal membrane disruption. These findings The increased blood urea nitrogen level group, while SOD higher Conclusion: has protective effects causing kidney

Language: Английский

Citations

1
Methanolic Extract of Morchella esculenta (Ascomycota), Prevents Chemotherapy Related Cardiotoxicity in Tumour Bearing Mice DOI

Sneha Das,

Anjana Mathew,

K. K. Janardhanan

et al.

International journal of medicinal mushrooms, Journal Year: 2024, Volume and Issue: 27(1), P. 51 - 61

Published: Sept. 3, 2024

The quest for bioactives that confer protection against chemotherapy induced cardio toxicity is a front-line area of oncology research. Species genus <i>Morchella</i> have been used in traditional medicine to treat asthma, wound healing, cough, cold, indigestion, excessive phlegm and breathlessness. <i>M. esculenta</i>, commonly known as guchhi India highly prized culinary morel mushroom. Recent studies carried out our laboratory demonstrated significant cardioprotective effect esculenta</i> doxorubicin (DOX)-induced cardiotoxicity. Since bioactive extracts mushrooms were found possess profound antioxidant activity, the possible interference these with antineoplastic activity drugs often surmised. current study was undertaken evaluate two anticancer drugs, DOX cyclophosphamide (CP) on solid tumor-bearing mice treated extract esculenta</i>. Solid tumor by subcutaneous injection Dalton's lymphoma ascites (DLA) cells right hind limbs Swiss albino mice. Animals administered various concentrations methanol (ME) following induction. Tumor growth (volume mass) measured four weeks after Cardioprotective methanolic assessed determining cardiac injury markers levels serum, status myocardium histopathology heart tissue. results showed ME esculenta </i>on findings also suggest did not delimit therapeutic CP despite its activity.

Language: Английский

Citations

0
Mild hypothermia alleviates cardiomyocyte necroptosis after cardiopulmonary resuscitation by regulating TRPV1 DOI Creative Commons

Meixian Yin,

Chuiliang Liu,

Yifang Zhu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 8, 2024

Abstract Background Therapeutic mild hypothermia (MH) is expected to improve the neurological outcome and survival rate of CPR after cardiac arrest (CA). However, whether how protects cardiomyocytes largely remains be explored. Methods Three four-month-old (age), 319.1-480.0 g (weight), male (sex) Wistar rats were randomly divided into normothermia (NT) groups (acceptable range, 36.0-38.0°C) MH 32-34°C). Then ten minutes CA, was perfumed by a slow injection 0.30-0.50 mL epinephrine solution (30.00 μg/mL). Moreover, test effect TRPV1, capsaicin injected through right femoral artery both in NT groups. Results We found that improved recovery spontaneous breathing, increased rate, inhibited necroptosis CPR. alleviated primary oxygen-glucose deprivation reperfusion up-regulating down-regulating EGFR, subsequently suppressing MLKL. Furthermore, capsaicin, TRPV1-activator, combined with MH, blood pressure when compared alone. Capsaicin breathing Conclusions may protect function TRPV1-inhibited cardiomyocyte necroptosis.

Language: Английский

Citations

0
Mild hypothermia alleviates cardiomyocyte necroptosis after cardiopulmonary resuscitation by regulating TRPV1 DOI Creative Commons

Meixian Yin,

Chuiliang Liu,

Yifan Zhu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Abstract Background Therapeutic mild hypothermia (MH) is expected to improve the neurological outcome and survival rate of CPR after cardiac arrest (CA). However, mechanisms by which MH protects cardiomyocytes remain largely unexplored. Methods In this study, three- four-month-old male Wistar rats, weighing between 319.1 480.0 grams, were randomly divided into normothermia (NT) groups (acceptable range, 36.0-38.0°C) 32-34°C). Ten minutes CA, was perfumed with a slow injection 0.30-0.50 mL epinephrine solution (30.00 μg/mL). Moreover, investigate role TRPV1, capsaicin administered through right femoral artery in both NT groups. Results We found that improved spontaneous breathing recovery, increased rate, inhibited necroptosis rats CPR. Additionally, alleviated primary oxygen-glucose deprivation reperfusion upregulating downregulating EGFR, subsequently suppressing MLKL. Furthermore, combination capsaicin, TRPV1 activator, enhanced blood pressure compared alone. Capsaicin Conclusions may protect function mitigating cardiomyocyte regulating TRPV1.

Language: Английский

Citations

0