Gut microbiota-driven metabolic alterations reveal the distinct pathogenicity of chemotherapy-induced cachexia in gastric cancer

Pharmacological Research, Journal Year: 2024, Volume and Issue: 209, P. 107476 - 107476

Published: Oct. 28, 2024

Language: Английский

Comparative Analysis of Microbiota in Jiani Yaks with Different Rib Structures

Life, Journal Year: 2024, Volume and Issue: 14(11), P. 1458 - 1458

Published: Nov. 10, 2024

The Jiani yak is a nationally renowned species that known for its meat which rich in various minerals, amino acids, and proteins. rumen microbiota plays critical role gastrointestinal health feed degradation, contributing proteins, lipids, volatile fatty acids (VFAs) essential milk production. However, there limited knowledge about the of free-ranging yaks, especially those with 15 ribs. Rumen fluid samples were collected from yaks 14 (PL) ribs (DL) slaughterhouse County, China. total DNA microorganisms was extracted sequencing. Our results revealed 643,713 656,346 raw sequences DL PL animals, respectively, 611,934 622,814 filtered these two groups. We identified 13,498 Amplicon Sequence Variants (ASVs), 2623 shared between animals. ratio Bacteroidota to Firmicutes differed (3.04) (2.35) Additionally, 6 phyla 21 genera showed significant differences ribs, leading altered functions, 51 35 notably different MetaCyc KEGG pathways, respectively. Hence, differs Therefore, microbiota-related comparative investigations will provide insights into husbandry practices genetic selection strategies their improved productivity harsh environments.

Language: Английский

The characteristics of intestinal flora of Tibetan sheep in different regions at high altitude were revealed based on metagenomic technique

Heliyon, Journal Year: 2024, Volume and Issue: 10(14), P. e34380 - e34380

Published: July 1, 2024

Tibetan sheep play a vital role in the livelihoods of herders and are an important part ecosystem Plateau. In order to study characteristics gut microorganisms at high altitude, this employed macrogenomic techniques analyse diversity differences flora different regions altitude cold. The results demonstrated that phylum level, dominant ileo-cecum segment Qilian, Henan Gonghe counties was identical, namely Euryarchaeota, Firmicutes Ascomycota. At level archaebacterial genus, bacteria ileocecal Qilian County, County were Methanobrevibacter. bacterial Bacteroides, while Bifidobacterium. fungal there notable abundance genus across regions. However, cecum exhibited more consistent trend From perspective functional prediction, metabolic pathways enriched intestinal segments found be with relative each gene also being essentially uniform. This result will provide foundation for further research on mechanism action microbes ruminants alpine

Language: Английский