Global warming and obesity: External heat exposure as a modulator of energy balance

FASEB BioAdvances, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Abstract In obesity research, the importance of core body temperature ( CBT ) regulation is often neglected. thermogenic regulation, however, plays a crucial role in heat management through convection, radiation, and conduction processes to remove from body, as well metabolic that sequester lipogenesis. This review emphasizes even small changes can significantly impact events ranging ATP production fat deposition. Accordingly, case made physical events, such external exposure, also compositional changes, do work processes. Examples are provided suggest independent diet exercise, where one lives, have an on composition obesity. For example, below 35 degrees earth's latitude, rates 40 percent or greater among adults. However, regions between 45 50 US ‐Canadian border, 25%–30%.

Language: Английский

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Neural network properties of hydrophilic polymers as a key for development of the general theory of evolution

Royal Society Open Science, Journal Year: 2025, Volume and Issue: 12(4)

Published: April 1, 2025

The analysis of the existing literature demonstrates that in order to address fundamental challenges associated with origin life, it is essential consider this problem from a comprehensive perspective, specifically vantage point general theory evolution complex systems. From these positions, life should be regarded as distinctive instance an information storage and processing system emerges naturally. Evolutionary processes examined coevolution material informational components, which has not been sufficiently emphasized hitherto. It shown specific example respect analogues neural networks spontaneously formed solutions some hydrophilic polymers. Such systems lead formation non-trivial objects. A wide range other examples considered, proving occurring participation polymers interpreted, among things, view objects, which, under certain conditions, influence at molecular supramolecular level. reasonable use tools classical dialectics solve such problems life.

Language: Английский

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Thermodynamic consistency of autocatalytic cycles

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(18)

Published: May 2, 2025

Autocatalysis is seen as a potential key player in the origin of life, and perhaps more generally emergence Darwinian dynamics. Building on recent formalizations this phenomenon, we tackle computational challenge exhaustively detecting minimal autocatalytic cycles (autocatalytic cores) reaction networks further evaluate impact thermodynamic constraints their realization under mass action kinetics. We first characterize complexity detection problem by proving its NP-completeness. This justifies use constraint solvers to list all cores given network, also group them into compatible sets, composed whose stoichiometric requirements are not contradictory. Crucially, show that introduction realism does constrain composition these sets. Compatibility relationships among can indeed be disrupted when kinetics obey consistency throughout network. On contrary, have no realizability isolated cores, unless upper or lower bounds imposed concentrations reactants. Overall, better characterizing conditions autocatalysis complex systems, work brings us step closer assessing contribution collective chemical behavior natural selection primordial soup.

Language: Английский

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A primitive cell model involving Vesicles, microtubules and asters

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 675, P. 700 - 711

Published: July 6, 2024

Language: Английский

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Thermodynamic consistency of autocatalytic cycles

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Autocatalysis is seen as a potential key player in the origin of life, and perhaps more generally emergence Darwinian dynamics. Building on recent formalizations this phenomenon, we tackle computational challenge exhaustively detecting autocatalytic cycles reactions networks, further evaluate impact thermodynamic constraints their realization under mass action kinetics. We first characterize complexity detection problem by proving its NP-completeness. This justifies use constraint solvers to list all given reaction network, also group them into compatible sets, composed whose stoichiometric requirements are not contradictory. Crucially, show that introduction realism does constrain composition these sets. Compatibility relationships among can indeed be disrupted when kinetics obey consistency throughout network. On contrary, have no realizability isolated cycles, unless upper or lower bounds imposed concentrations reactants. Overall, better characterizing conditions autocatalysis complex systems, work brings us step closer assessing contribution collective chemical behavior natural selection primordial soup. Significance Statement Describing processes behind life requires understand self-amplifying dynamics systems. Detecting critical but difficult endeavor. After problem, investigate autocatalysis. demonstrate individual regardless parameters, activated long entities may occur at any required concentration. In contrast, two become mutually incompatible due constraints, will thus never run simultaneously. These results clarify implications physical

Language: Английский

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Various Viewpoints to Investigate the Origins of Life Are Needed

Life, Journal Year: 2024, Volume and Issue: 14(10), P. 1324 - 1324

Published: Oct. 18, 2024

How life first arose on Earth is a mystery that humankind has sought to understand for millennia, and includes scientific, philosophical, societal, religious aspects, amongst others [...]

Language: Английский

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