Extracellular vesicles as dynamic biomarkers: Monitoring therapeutic responses and drug resistance in cancer
International review of cell and molecular biology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Language: Английский
Nanoscale Extracellular Vesicle-Enabled Liquid Biopsy: Advances and Challenges for Lung Cancer Detection
Micromachines,
Journal Year:
2024,
Volume and Issue:
15(10), P. 1181 - 1181
Published: Sept. 24, 2024
Lung
cancer
is
responsible
for
the
death
of
over
a
million
people
worldwide
every
year.
With
its
high
mortality
rate
and
exponentially
growing
number
new
cases,
lung
major
threat
to
public
health.
The
poor
survival
rates
patients
can
be
attributed
stealth
progression
late
diagnosis.
For
long
time,
intrusive
tissue
biopsy
has
been
considered
gold
standard
diagnosis
subtyping;
however,
intrinsic
limitations
cannot
overlooked.
In
addition
being
invasive
costly,
it
also
suffers
from
in
sensitivity
specificity,
not
suitable
repeated
sampling,
provides
restricted
information
about
tumor
molecular
landscape,
inaccessible
several
cases.
To
cope
with
this,
advancements
diagnostic
technologies,
such
as
liquid
biopsy,
have
shown
great
prospects.
Liquid
an
innovative
non-invasive
approach
which
cancer-related
components
called
biomarkers
are
detected
body
fluids,
blood,
urine,
saliva
others.
It
offers
less
alternative
potential
applications
routine
screening,
predicting
treatment
outcomes,
evaluating
effectiveness,
detecting
residual
disease,
or
disease
recurrence.
A
large
research
articles
indicated
extracellular
vesicles
(EVs)
ideal
biopsy.
EVs
heterogeneous
collection
membranous
nanoparticles
diverse
sizes,
contents,
surface
markers.
play
critical
role
pathophysiological
states
gained
prominence
prognostic
multiple
diseases,
including
cancer.
this
review,
we
provide
detailed
overview
EV-based
Moreover,
highlights
strengths
weaknesses
various
contemporary
techniques
EV
isolation
analysis
challenges
that
need
addressed
ensure
widespread
clinical
application
biopsies
summary,
present
interesting
opportunities
development
novel
platforms
cancer,
one
most
abundant
cancers
millions
deaths
worldwide.
Language: Английский
Surface-Bioengineered Extracellular Vesicles Seeking Molecular Biotargets in Lung Cancer Cells
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(25), P. 31997 - 32016
Published: June 13, 2024
Personalized
medicine
is
a
new
approach
to
modern
oncology.
Here,
facilitate
the
application
of
extracellular
vesicles
(EVs)
derived
from
lung
cancer
cells
as
potent
advanced
therapy
medicinal
products
in
cancer,
EV
membrane
was
functionalized
with
specific
ligand
for
targeting
purposes.
In
this
role,
most
effective
heptapeptide
binding
(PTHTRWA)
used.
The
functionalization
process
surface
performed
through
C-
or
N-terminal
end
heptapeptide.
To
prove
activity
EVs
PTHTRWA,
both
model
lipid
mimicking
normal
and
cancerous
cell
membranes
well
human
adenocarcinomic
alveolar
basal
epithelial
(A549)
bronchial
(BEAS-2B)
have
been
exposed
these
bioconstructs.
Magnetic
resonance
imaging
(MRI)
showed
that
as-bioengineered
PTHTRWA-EVs
loaded
superparamagnetic
iron
oxide
nanoparticle
(SPIO)
cargos
reach
growing
tumor
when
dosed
intravenously
NUDE
Balb/c
mice
bearing
A549
cancer.
Molecular
dynamics
(MD)
silico
studies
elucidated
high
affinity
synthesized
peptide
α5β1
integrin.
Preclinical
safety
assays
did
not
evidence
any
cytotoxic
genotoxic
effects
PTHTRWA-bioengineered
EVs.
Language: Английский
Wildfire-Relevant Woodsmoke and Extracellular Vesicles (EVs): Alterations in EV Proteomic Signatures Involved in Extracellular Matrix Degradation and Tissue Injury in Airway Organotypic Models
Eva C.M. Vitucci,
No information about this author
Celeste K. Carberry,
No information about this author
Alexis Payton
No information about this author
et al.
Environmental Research,
Journal Year:
2024,
Volume and Issue:
unknown, P. 120395 - 120395
Published: Nov. 1, 2024
Language: Английский