Interdisciplinarity in Cardiovascular Diseases—A Necessity Alongside the Heart Team

Life, Journal Year: 2025, Volume and Issue: 15(2), P. 193 - 193

Published: Jan. 28, 2025

Cardiovascular disease often requires multidisciplinary collaboration in order to achieve an appropriate diagnosis and optimal patient outcomes [...]

Language: Английский

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Morphopathology of the lesions induced by SARS-CoV-2 infection in the lungs

Romanian Journal of Morphology and Embryology, Journal Year: 2025, Volume and Issue: 65(4), P. 637 - 645

Published: Feb. 13, 2025

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection spread rapidly from China around the world, causing worst pandemic since beginning of 21st century. Although disease named 2019 (COVID-19) has multiple organ symptoms, main pathological lesions occur in lung, failure, pulmonary embolism, secondary bacterial pneumonia and fibrosis. Despite best efforts researchers, pathogenesis SARS-CoV-2-induced cellular tissue damage organs systems is poorly understood. Therefore, our study, we aimed to highlight their extent, which could explain complex symptomatology presented by patients who died with distress (ARDS). The study was performed on a number 36 diagnosed COVID-19 under legally suspicious conditions, requiring autopsy within Romanian Forensic Medicine Institutes. All local inflammatory reaction pneumonic type, exudative proliferative phenomena, intra-alveolar interstitial infiltrates formed lymphocytes, macrophages neutrophilic granulocytes, congested or ruptured blood vessels hemorrhages, thrombosis, proliferation fibroblasts transformed into myofibroblasts presence granulation that remodeled entire lung parenchyma.

Language: Английский

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Infectious diseases, cardio-cerebrovascular health and vaccines: pathways to prevention

Aging Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: March 13, 2025

Abstract Cardiovascular and infectious diseases both feature among the leading causes of death men women in world. The pathophysiological pathways infection cardiovascular disease intersect, there is a bidirectional relationship between two. Vaccines are available for most common affecting older adults, such as influenza, pertussis, pneumococcal disease, herpes zoster, COVID respiratory syncytial virus (RSV). In many countries, these vaccines recommended systematically adults any with comorbidities, who also those likely to suffer from disease. There large body evidence attesting benefits vaccination on cardio- cerebrovascular health. European Interdisciplinary Council Aging (EICA) Italian Society Prevention (Società Italiana per la Prevenzione Cardiovascolare, SIPREC) convened 2-day meeting June 2024 review state health diseases, role preventing its adverse consequences terms outcomes. We present here Executive Summary proceedings this meeting.

Language: Английский

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Increase of VEGF and Fibronectin expression and ultrastructural alterations of intercellular junctions in a swab negative patient after SARS-COV-2 infection

Virology Journal, Journal Year: 2025, Volume and Issue: 22(1)

Published: March 21, 2025

SARS-CoV-2 infection has been responsible of COrona VIrus Disease (COVID-19) pandemia and can cause a variety symptoms including gastrointestinal disorders, abdominal pain liver injury. The host receptor for SARS-CoV-2, ACE2, is expressed in gut could induce vascular damage immune system dysregulation, creating an inflammatory hypercoagulable state, as widely described at the lung level. This work presents case middle-aged Caucasian man admitted to Hospital Emergency Department from University Ferrara (Italy), complaining upper middle region abdomen. patient tested negative nose-oropharyngeal swab four weeks after recovering viral infection. required resection segment ileum ulcer bowel wall was recognized sampled. Previous published results had confirmed presence nucleocapsid protein, increased human leukocyte antigen (HLA-G) altered morphology microvilli ulcerated when compared non-ulcerated ileum. present study sought deepen consequences To this end, we evaluated expression co-expression Vascular Endothelial Growth Factor (VEGF) Fibronectin by immunohistochemical techniques. VEGF higher than control sample areas co-expressed with SPIKE protein. staining lower Electron microscopy analysis showed alterations integrity intestinal barrier area or sample. Although protein detected his terminal ileum, especially areas. also associated increase Fibronectin. In addition changes, junctional apparatus among epithelial cells, making tissue even more fragile thus susceptible entry pathogens development further infections.

Language: Английский

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Variability in Arterial Stiffness and Vascular Endothelial Function After COVID-19 During 1.5 Years of Follow-Up—Systematic Review and Meta-Analysis

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 520 - 520

Published: March 21, 2025

Increasing long-term observations suggest that coronavirus disease 2019 (COVID-19) vasculopathy may persist even 1.5 years after the acute phase, potentially accelerating development of atherosclerotic cardiovascular diseases. This study systematically reviewed variability brachial flow-mediated dilation (FMD) and carotid-femoral pulse wave velocity (cfPWV) from phase COVID-19 through 16 months follow-up (F/U). Databases including PubMed, Web Science, MEDLINE, Embase were screened for a meta-analysis without language or date restrictions (PROSPERO reference CRD42025642888, last search conducted on 1 February 2025). The quality included studies was assessed using Newcastle–Ottawa Quality Scale. We considered all (interventional pre-post studies, prospective observational randomized, non-randomized trials) FMD cfPWV in adults (aged ≥ 18 years) with laboratory-confirmed compared non-COVID-19 controls changes these parameters during F/U. Twenty-one reported differences FMD, examined between patients control groups various stages: acute/subacute (≤30 days onset), early (>30–90 days), mid-term (>90–180 late (>180–270 very (>270 days) post-COVID-19 recovery. Six while nine did so Data 14 (627 cases 694 controls) 15 (578 703 our meta-analysis. showed significant decrease to (standardized mean difference [SMD]= −2.02, p < 0.001), partial improvements noted recovery (SMD = 0.95, 0.001) 0.92, 0.006). Normalization observed 0.12, 0.69). In contrast, values, which higher than 1.27, remained elevated throughout F/U, no except (SMD= −0.39, 0.001). recovery, values those 0.45, 0.010). manuscript, we discuss how factors, severity COVID-19, persistence syndrome, patient’s initial vascular age, depending metrics age risk influenced time degree improvement.

Language: Английский

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Предиктори прогресування серцевої недостатності у хворих на ІХС у поєднанні з COVID-19

Ukrainian Journal of Military Medicine, Journal Year: 2025, Volume and Issue: 6(1), P. 147 - 158

Published: March 31, 2025

Мета: дослідити зв’язок показників церебральної гемодинаміки і мікроциркуляції з прогресуванням серцевої недостатності у хворих на ішемічною хворобою серця (ІХС) та COVID-19. Методи: З січня 2020 року по грудень 2022 було проведено дослідження, в якому взяли участь 79 пацієнтів ІХС без ознак COVID-19, а також 127 осіб хронічною поєднанні COVID-19 180 пацієнтів, які мали ІХС. Дослідження проходило клінічних базах Національного медичного університету імені ОО Богомольця, зокрема 18 клінічній лікарні Києва медичному центрі «Медбуд». Проводили: емболодетекцію визначенням кількості мікроемболічних сигналів (МЕС), ультразвукове дослідження судин голови шиї: вимірювали комплекс інтіма-медіа (КІМ), пікову систолічну швидкість правій лівій середній мозковій артерії (СМАп, СМАл), задніх мозкових артеріях (ЗМАп, ЗМАл), базилярній (БА), Д-димер, Феритин, за даними лазерної доплерівської флоуметрії: тип МКЦ, амплітуду ендотеліальних флаксмоцій (АЕФ), дихальних (АДФ), цифрової капіляроскопії: довжину артеріальної частини капіляру (ДА), венозної (ДВ), швидіксть кровотоку артеріальній частині (ША), розмір перехідної зони (ПЗ), ангіорезистометрії кількість петехій після проби (АРМ1), через 5 хв. (АРМ2), Результати. У із супутнім спостерігаються найбільше зниження церебрального кровотоку, виражене погіршення мікроциркуляції, більші значення феритину Д-димеру. В однофакторній моделі логістичної регресії виявлено слабкий ризику фракції викиду лівого шлуночку показниками МЕС, КІМ, СМАп, СМАл, ЗМАп, ЗМАл, БА, ПЗ, типу АРМ1, АРМ2, АЕФ, АДФ, ДА, ДВ, ША. багатофакторної зростання прогресування при ВШ=10.5 (95% 2.27 – 48.2), умов врахування пікової швидкості обох середніх артерія, сегменті Р2 правої задньої мозкової артерії, рівня феритину, довжини капіляру, площа під кривою операційних характеристик AUC = 0.80 ВІ 0.75 0.83). Висновки. Запропоновано використовувати індекс оцінки для IF відповідною шкалою широкого використання практиці. Існує потреба методах неінвазивної властивостей мікросудинної реактивності метою визначення прогнозу перебігу хронічну

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Biomarkers of Oxidative Stress in COVID-19 Patients

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3869 - 3869

Published: April 19, 2025

We focused on evaluating oxidative stress as a major mechanism of cell damage in patients with COVID-19 infection by simultaneously assessing standard biomarkers vivo—for the very first time this specific combination—alongside typical clinical inflammation. Standard were used to evaluate status and antioxidant activity blood plasma healthy controls. These included TBARSs (Thiobarbituric Acid-Reactive Substances), SOD (Super Oxide Dismutase), CAT (catalase), GRA (glutathione reductase) activities, AOC (antioxidant capacity). All inflammation data confirmed highly activated immune response tested patients: WBCs (white cells) increased nearly 100%, LYMs (lymphocytes) ~30%, CRP (C-reactive protein) rose over 2200%, ESR (erythrocyte sedimentation rate) ~320% compared established maximum control levels. The results that involved free-radical-mediated mechanism: TBARS levels almost 3-fold, decreased more than 4-fold, was 5-fold, 1.4 times, suppressed 2.5 times. associated activity. these changes contribute severity disease, complications, mortality patients.

Language: Английский

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The Involvement and Manifestations of SARS-CoV-2 Virus in Cardiovascular Pathology

Medicina, Journal Year: 2025, Volume and Issue: 61(5), P. 773 - 773

Published: April 22, 2025

Although the acute phase of COVID-19 pandemic has subsided, emergence post-COVID-19 condition presents a new and complex public health challenge, characterized by persistent, multisystem symptoms that can endure for weeks or months after initial infection with SARS-CoV-2 virus, significantly affecting survivors’ quality life. Among most concerning sequelae are cardiovascular complications, which encompass broad spectrum conditions, including arrhythmias, myocardial damage, postural orthostatic tachycardia syndrome. This narrative review explores burden on reviewing latest relevant findings in literature highlighting different aspects COVID-19’s involvement. investigates pathophysiological mechanisms underlying involvement condition, focus direct viral invasion via ACE2 receptors, immune-mediated injury, cytokine storm, systemic inflammation, endothelial dysfunction, mitochondrial injury. The interplay between pre-existing diseases, such as hypertension, atherosclerosis, diabetes, atrial fibrillation, is also explored, revealing individuals conditions at heightened risk both severe illness long-term complications. Long-term immune activation persistence antigens increasingly recognized contributors to ongoing even mild asymptomatic infections. As healthcare system continues adapt consequences pandemic, deeper understanding these manifestations essential. knowledge will inform development targeted strategies prevention, clinical management, rehabilitation affected patients. Furthermore, insights gained from intersection be instrumental shaping responses future epidemics, necessity multidisciplinary approaches patient care preparedness.

Language: Английский

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COVID-19 as a critical risk factor for osteonecrosis of the jaw: diagnostic challenge and surgical treatment

Current Problems in Surgery, Journal Year: 2024, Volume and Issue: 61(9), P. 101555 - 101555

Published: July 2, 2024

This case report describes a unique and complex presentation of osteonecrosis the maxilla, complicated by Aspergillosis Mucormycosis, developed in an immunocompetent patient recovering from COVID-19. The presented with range clinical symptoms, including facial pain, rhinorrhea, cacosmia, cough, radiographic evidence jaw involvement. Cytological histological examinations revealed presence Aspergillus niger mucormycosis-like fungal elements. Our discusses main diagnostic challenges, different potential etiopathological hypotheses, alternative therapeutic rehabilitative approaches. atypical surgical definitely highlights need for heightened awareness among healthcare professionals, regarding risk to discover severe opportunistic infections also COVID-19 patients; this further sheds light on importance multidisciplinary approach effective management such intricate post-COVID-19 complications.

Language: Английский

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Perspective Chapter: Respiratory Disorders and Brain Damage in Long COVID

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

In the last few years, we have realized that COVID-19 is a risk factor for new chronic diseases such as heart disease, diabetes, kidney hematologic disorders, neurologic conditions, and cognitive disorders. Long symptoms continue or develop after initial SARS-CoV-2 infection 4 weeks more. Some of our patients who recovered from may experience varying degrees functional impairment, radiological sequelae, persistent requiring prolonged follow-up. Respiratory disorders are manifested by cough breathing difficulties along with brain expressed dysfunction. The “brain fog symptom” collective term used to describe deficiencies in attention, executive functioning, language performance, processing speed, memory among patients. A significant proportion morbidity associated COVID due syndrome impairment well increased anxiety, depression, sleep fatigue, deprivation. Our findings indicate abnormalities emphasize value neurological follow-up individuals.

Language: Английский

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