Life, Journal Year: 2024, Volume and Issue: 14(11), P. 1503 - 1503
Published: Nov. 18, 2024
Shift work has been associated with unhealthy lifestyle habits and a higher prevalence of obesity, which negatively impacts the health shift workers. The objective our study was to examine influence on as well sociodemographic variables, anthropometric measurements, in individuals working this type schedule.
Language: Английский
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 151, P. 114345 - 114345
Published: March 1, 2025
Language: Английский
Citations
2
Cytokine, Journal Year: 2025, Volume and Issue: 186, P. 156852 - 156852
Published: Jan. 6, 2025
Language: Английский
Citations
1
Clinics and Practice, Journal Year: 2025, Volume and Issue: 15(1), P. 18 - 18
Published: Jan. 14, 2025
Background: The purpose of this article is to overview the clinical significance left supraclavicular adenopathy and review etiology inferior vena cava (IVC) thrombosis, starting from a presentation rare case renal cell carcinoma (RCCs) with Xp11.2 translocation involving TFE3 gene fusion. This also aims literature understand characteristics type tumor. Renal (RCC) associated translocation/gene fusion subtype kidney cancer that was classified in 2016 as belonging family carcinomas MiT (microphthalmia-associated transcription factor). prognosis for these cancers poorer compared other types. Methods: We present 66-year-old man Virchow–Troisier during physical examination, which raises suspicion infra-diaphragmatic echocardiography highlighted heterogeneous mass right cardiac cavities, abdominal ultrasound exam revealed solid at upper pole kidney. Results: Following computed tomography, magnetic resonance imaging, PET-CT, histopathological immunohistochemical examinations, patient diagnosed Conclusions: IVC thrombosis often neoplastic disease due procoagulant state patients, most common malignancies related being represented by RCCs (38%), genitourinary (25%), bronchus lung cancers, retroperitoneal leiomyosarcoma, adrenal cortical carcinoma. Imaging methods play crucial role differential diagnosis, allowing localization primary tumor assessment its characteristics.
Language: Английский
Citations
1
Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 2129 - 2129
Published: Sept. 19, 2024
Adipose tissue was previously regarded as a dormant organ for lipid storage until the identification of adiponectin and leptin in early 1990s. This revelation unveiled dynamic endocrine function adipose tissue, which has expanded further. emerged recent decades multifunctional that plays significant role energy metabolism homeostasis. Currently, it is evident primarily performs its by secreting diverse array signaling molecules known adipokines. Apart from their pivotal expenditure regulation, these adipokines exert influence over multitude biological processes, including but not limited to inflammation, thermoregulation, immune response, vascular function, insulin sensitivity. Adipokines are regulating numerous processes within facilitating communication between various organs, brain, gut, pancreas, endothelial cells, liver, muscle, more. Dysregulated have been implicated several metabolic diseases, like obesity diabetes, well cardiovascular diseases. In this article, we attempted describe significance developing diseases highlight crosstalk tissues other organs.
Language: Английский
Citations
8
Infectious Disease Reports, Journal Year: 2025, Volume and Issue: 17(1), P. 6 - 6
Published: Jan. 10, 2025
Objectives: Spondylodiscitis can be caused by various microorganisms and has shown a continuous rise in incidence mortality. The purpose of our study was to analyze the demographic laboratory data, as well comorbidities patients that were surgically treated for spondylodiscitis hospital. causative pathogens involved etiology spinal infections also assessed. Methods: included 92 who underwent clinical, radiological, microbiological analyses including bacterial isolation. According their culture results, divided into three groups: negative results (n = 29), positive with Mycobacterium tuberculosis (M. tb.) 26), other pathological agents 37). Results: Patients M. tb. had significantly lower body mass index (p 0.022) younger 0.024) than others. analysis complete blood work showed significant differences between groups regarding fibrinogen levels 0.023), C-reactive protein 0.009), erythrocyte sedimentation rates 0.042). Results 0.023) diabetes mellitus more prone compared without disease. Conclusions: These findings have important implications adopting individualized treatment strategies underlining need identification at high risk specific pathogens.
Language: Английский
Citations
0
Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 873 - 873
Published: Jan. 28, 2025
Background: There is insufficient evidence regarding the independent risk of childhood/adolescent obesity for morbidity and mortality in adulthood. The objective present study was to evaluate association weight categories during adolescence with high-risk diseases determined by Charlson Comorbidity Index young We also analyzed cumulative at age 30. Methods: A retrospective cohort study, based on central computerized database a major health service organization, conducted. population consisted 80,853 adolescents. period from 1 January 2007 31 December 2022 divided into exposure 2011 (ages 17–19) follow-up (from date defining BMI measurement up 30 years). Results: five highest incidence were chronic pulmonary disease (8.2%), mild liver (3.7%), cerebrovascular (2.8%), diabetes without end-organ damage (2.0%), peptic (1.6%). When adjusted socio-demographic variables adult BMI, relative risks 95% confidence intervals increase 1.11 (1.05–1.17), 1.17 (1.11–1.24), 1.22 (1.09–1.35) “overweight”, “obesity”, “class 2 obesity” categories, respectively, while these 1.60 (1.11–2.27), 1.71 (1.12–2.57), 3.18 (1.48–6.35), respectively. Conclusions: Adolescent an factor Interventions aimed reducing rate adolescent overweight should be implemented as early possible.
Language: Английский
Citations
0
International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(2), P. 207 - 207
Published: Jan. 31, 2025
Low-grade metabolic inflammation is associated with several chronic disorders, including obesity. However, no concrete evidence that supports obesity as a direct cause of inflammation. This study aims to identify the association in apparently healthy adults. In this study, 162 seemingly volunteers, aged between 20 and 40 years, comparable sex ratio, were recruited categorized based on their body mass index (BMI) into four scales: normal (N), overweight (OW), obese (OB), severely (SOB). After clinical examination, fasting blood samples collected from subjects for glycemic (fasting glucose-FBG, HbA1c) lipid (total cholesterol, LDL-C, HDL-C, triacyl glycerides -TAG) profile analysis. addition, plasma levels panel diverse inflammatory biomarkers, IL6, IL8, procalcitonin (PCT), TREM1, uPAR analyzed by sandwich ELISA. The results showed LDLC, TAG, FBG, HbA1c significantly higher (OB SOB) group, compared non-obese (N OW) while HDLc was lower. biomarker not correlated age or differed males females. Importantly, all assessed biomarkers classes. Moreover, dyslipidemia dysglycemia those profiles. Finally, obesity, glycemic, lipidemic parameters. correction co-morbidities, our deny discrete probably dyslipidemia, systemic Further studies local non-elderly, are needed.
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 149, P. 114211 - 114211
Published: Feb. 9, 2025
Language: Английский
Citations
0
Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 115 - 115
Published: Feb. 11, 2025
Cholesterol is an essential element for the development and normal function of central nervous system. While peripheral cholesterol influenced by liver metabolism diet, brain takes place in isolated system due to impermeability blood–brain barrier (BBB). However, cross-talk occurs between periphery, specifically through metabolites such as oxysterols that play key roles regulating balance. Several neurodegenerative conditions Alzheimer’s disease or Parkinson’s are considered be affected loss this Also, treatment hypercholesterolemia needs consider these discrete interferences possible implications each therapeutic approach. This particularly important because 27-hydroxycholesterol 24-hydroxycholesterol, which can cross BBB involved metabolism. paper examines metabolic pathways periphery focuses on complex metabolisms. we emphasize regulatory role need integrated approach management.
Language: Английский
Citations
0
Diabetes Mellitus, Journal Year: 2025, Volume and Issue: 27(6), P. 528 - 535
Published: Jan. 18, 2025
BACKGROUND : The prevalence of overweight and obesity in patients with type 1 diabetes (T1D) is increasing, which raises the issue their impact on development complications. AIM to study associations vascular complications, cardiovascular risk factors serum levels remodeling biomarkers T1D. MATERIALS AND METHODS included 547 patients, including 309 body mass index (BMI) <25 kg/m 2 , 155 BMI 25–29.9 83 ≥30 . Insulin sensitivity was assessed by estimated glucose disposal rate. In 130 30 individuals normal weight tolerance, concentrations advanced glycation end products (AGEs), endothelin-1, endothelial NO synthase (NOS3), adrenomedullin (ADM), cell-specific molecule-1 (ESM1), cell adhesion molecules (ICAM-1 VCAM-1), integrin-associated protein-1 (IAP-1), integrin receptor subunit (ITGB1), heme oxygenase-1 (HO-1), GAS6, decorin, transforming growth factor β1 (TGF-β1) were determined ELISA. RESULTS Obesity T1D independently associated coronary artery disease, myocardial infarction, chronic heart failure. Overweight an independent predictor failure only. Patients ≥25 when compared those older, had a reduced insulin increased triglycerides, LDL-cholesterol, uric acid, high-sensitivity C-reactive protein. T1D, as controls, showed significant increase AGEs, ICAM-1, VCAM-1, IAP-1, ESM1, HO-1, TGF-β1. demonstrated higher ITGB1 TGF-β1, while obese IAP-1 HO-1. CONCLUSION are remodeling.
Language: Английский
Citations
0