Life, Journal Year: 2024, Volume and Issue: 14(11), P. 1503 - 1503
Published: Nov. 18, 2024
Shift work has been associated with unhealthy lifestyle habits and a higher prevalence of obesity, which negatively impacts the health shift workers. The objective our study was to examine influence on as well sociodemographic variables, anthropometric measurements, in individuals working this type schedule.
Language: Английский
Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2025, Volume and Issue: unknown, P. 203 - 256
Published: Jan. 3, 2025
This chapter explores the intricate relationship between oxidative stress and metabolic diseases, specifically diabetes obesity. It begins with an overview of these conditions, emphasizing their global impact associated dysfunctions. The discussion shifts to biochemical mechanisms stress, focusing on mitochondrial dysfunction ROS production. examines how affects pancreatic beta-cell function insulin resistance, linking hyperglycemia increased damage. Additionally, addresses adipose tissue interplay inflammation in obesity-related complications. concludes by discussing strategies mitigate through pharmacological lifestyle interventions, such as antioxidant therapies, dietary changes, regular exercise, caloric restriction. comprehensive approach aims provide insights into effectively managing thereby improving health addressing challenges posed
Language: Английский
Citations
0
Cancer Biology & Therapy, Journal Year: 2025, Volume and Issue: 26(1)
Published: May 12, 2025
The epidemic of obesity is a growing concern and one the major risk factors for several chronic diseases, including types cancers. correlation breast cancer with has been extensively studied involves an interplay hormonal, metabolic, genetic explored in this review. Inflammation hormone dysregulation play important role promoting protumorigenic environment through adipose tissue, which involved energy storage functions as endocrine organ. As result, various cytokines, primarily proinflammatory nature, are released, resulting low-grade inflammation tumor growth. Additionally, obese conditions also induce imbalances hormones, particularly estrogen insulin, both drive carcinogenesis. Genetic components such single nucleotide polymorphisms critical roles modulating between cancer. This review provides comprehensive overview mechanisms underlying incidence progression.
Language: Английский
Citations
0
Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(5), P. 357 - 357
Published: May 13, 2025
Obesity, a global health concern of increasing significance, is characterized by chronic low-grade inflammation (LGCI) that significantly contributes to metabolic dysfunction. This narrative review explores the intricate pathophysiological mechanisms driving LGCI in obesity, emphasizing role adipose tissue, immune cell activation, and inflammatory signaling pathways. Hypertrophic adipocytes infiltrating cells, particularly macrophages, release cascade pro-inflammatory cytokines, including TNF-α, IL-6, IL-1β, creating self-perpetuating cycle inflammation. These mediators disrupt insulin through JNK NF-κB pathway leading systemic resistance, cardiovascular complications, gut dysbiosis other disorders. The further discusses therapeutic strategies mitigate obesity-related LGCI, focusing on lifestyle interventions, nutritional approaches, pharmacological agents. Physical activity, specific nutrients, dietary patterns can modulate responses, while anti-obesogenic medicines bariatric procedures offer additional avenues for intervention. By understanding addressing root causes healthcare professionals develop targeted improve overall well-being individuals with obesity and, ultimately, prevent manage wide-ranging complications associated this condition.
Language: Английский
Citations
0
Heart Failure Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: May 14, 2025
Abstract Heart failure (HF) remains a leading cause of morbidity and mortality worldwide, with inflammation playing pivotal role in its pathogenesis. This comprehensive review aims to elucidate the intricate mechanisms by which contributes development progression HF. The synthesizes current research on involvement both innate adaptive immune responses HF, highlighting roles cytokines, chemokines, other inflammatory mediators. Recent studies have demonstrated that chronic inflammation, driven factors such as oxidative stress, neurohormonal activation, metabolic disturbances, leads adverse cardiac remodeling impaired myocardial function. explores how systemic characterized elevated levels biomarkers like C-reactive protein (CRP) interleukin-6 (IL-6), correlates HF severity outcomes. Additionally, it discusses impact comorbid conditions diabetes, obesity, hypertension pathways risk. also delves into therapeutic implications targeting Despite mixed results from early clinical trials, emerging evidence suggests anti-inflammatory therapies offer benefits specific phenotypes. potential novel strategies, including use biologics small molecule inhibitors, is examined context their ability modulate improve
Language: Английский
Citations
0
Life, Journal Year: 2024, Volume and Issue: 14(11), P. 1503 - 1503
Published: Nov. 18, 2024
Shift work has been associated with unhealthy lifestyle habits and a higher prevalence of obesity, which negatively impacts the health shift workers. The objective our study was to examine influence on as well sociodemographic variables, anthropometric measurements, in individuals working this type schedule.
Language: Английский
Citations
3