Variability in Arterial Stiffness and Vascular Endothelial Function After COVID-19 During 1.5 Years of Follow-Up—Systematic Review and Meta-Analysis
Life,
Journal Year:
2025,
Volume and Issue:
15(4), P. 520 - 520
Published: March 21, 2025
Increasing
long-term
observations
suggest
that
coronavirus
disease
2019
(COVID-19)
vasculopathy
may
persist
even
1.5
years
after
the
acute
phase,
potentially
accelerating
development
of
atherosclerotic
cardiovascular
diseases.
This
study
systematically
reviewed
variability
brachial
flow-mediated
dilation
(FMD)
and
carotid-femoral
pulse
wave
velocity
(cfPWV)
from
phase
COVID-19
through
16
months
follow-up
(F/U).
Databases
including
PubMed,
Web
Science,
MEDLINE,
Embase
were
screened
for
a
meta-analysis
without
language
or
date
restrictions
(PROSPERO
reference
CRD42025642888,
last
search
conducted
on
1
February
2025).
The
quality
included
studies
was
assessed
using
Newcastle–Ottawa
Quality
Scale.
We
considered
all
(interventional
pre-post
studies,
prospective
observational
randomized,
non-randomized
trials)
FMD
cfPWV
in
adults
(aged
≥
18
years)
with
laboratory-confirmed
compared
non-COVID-19
controls
changes
these
parameters
during
F/U.
Twenty-one
reported
differences
FMD,
examined
between
patients
control
groups
various
stages:
acute/subacute
(≤30
days
onset),
early
(>30–90
days),
mid-term
(>90–180
late
(>180–270
very
(>270
days)
post-COVID-19
recovery.
Six
while
nine
did
so
Data
14
(627
cases
694
controls)
15
(578
703
our
meta-analysis.
showed
significant
decrease
to
(standardized
mean
difference
[SMD]=
−2.02,
p
<
0.001),
partial
improvements
noted
recovery
(SMD
=
0.95,
0.001)
0.92,
0.006).
Normalization
observed
0.12,
0.69).
In
contrast,
values,
which
higher
than
1.27,
remained
elevated
throughout
F/U,
no
except
(SMD=
−0.39,
0.001).
recovery,
values
those
0.45,
0.010).
manuscript,
we
discuss
how
factors,
severity
COVID-19,
persistence
syndrome,
patient’s
initial
vascular
age,
depending
metrics
age
risk
influenced
time
degree
improvement.
Language: Английский
WNT Signaling Cascade Proteins and Structural and Functional State of The Vascular Bed in Patients With Various Phenotypes of Stable Ischemic Heart Disease
Kardiologiia,
Journal Year:
2025,
Volume and Issue:
65(3), P. 3 - 9
Published: March 31, 2025
Aim
To
evaluate
the
concentration
of
WNT
signaling
cascade
proteins
(WNT1,
-3a,
-4,
-5a)
and
state
vasculature
by
photoplethysmography
(PPG)
in
patients
with
different
phenotypes
stable
ischemic
heart
disease
(IHD),
obstructive
non-obstructive
coronary
artery
(CAD).
Material
methods
This
cross-sectional
observational
study
included
80
(45-75
years
old)
a
verified
diagnosis
IHD.
Based
on
results
angiography
or
multislice
spiral
computed
tomography
angiography,
were
divided
into
two
equal
groups
(n=40),
IHD
(oIHD),
ischemia
no
CAD
angina
(INOCA/ANOCA).
In
oIHD
group,
men
prevailed
(67.5%)
while
INOCA/ANOCA
women
(57.5%).
Noninvasive
PPG
evaluation
was
performed,
WNT1,
-5a
concentrations
measured
ELISA
all
patients.
Results
Higher
WNT1
WNT3a
found
(p<0.001)
group
had
significantly
higher
WNT5a
(p=0.001).
According
to
data,
arterial
stiffness
index
(aSI)
differed
between
(7.6
m/s
[6.6;
9.35])
(9.25
[7.88;
10.33])
groups,
p=0.048).
The
correlation
analysis
revealed
relationship
reflectance
RI
(ρ=0.359;
p=0.014)
(oIHD+INOCA/ANOCA).
ROC
analysis,
curve
for
turned
out
be
diagnostically
significant
(sensitivity
specificity
model
85.7
87.0%,
respectively).
cut-off
value
0.183
pg/ml.
Conclusion
showed
that
activation
canonical
(WNT1
WNT3a)
observed
oIHD,
non-canonical
(WNT5a)
activated
INOCA/ANOCA.
phenotype
can
predicted
≥0.183
Language: Английский
Insights into the Risk Factors and Outcomes of Post-COVID-19 Syndrome—Results from a Retrospective, Cross-Sectional Study in Romania
Life,
Journal Year:
2024,
Volume and Issue:
14(11), P. 1519 - 1519
Published: Nov. 20, 2024
Post-Coronavirus
Disease
2019
(post-COVID-19)
syndrome
represents
a
cluster
of
persistent
symptoms
following
Severe
Acute
Respiratory
Syndrome
Coronavirus
2
(SARS-CoV-2)
infection
that
can
severely
affect
quality
life.
The
pathogenic
mechanisms
and
epidemiology
in
different
regions
are
still
under
evaluation.
To
assess
the
outcomes
post-COVID-19
syndrome,
we
performed
questionnaire-based,
cross-sectional
study
previously
infected
individuals.
Out
549
respondents,
(male:female
ratio:
0.32),
29.5%
had
at
3
months,
23.5%
6
18.3%
12
months
after
initial
infection.
most
common
included
fatigue
(8.7%),
sleep
disturbances
(7.1%),
cognitive
impairment
(6.4%).
risk
developing
increased
for
those
with
more
acute
phase
(OR
4.24,
Language: Английский