Photosensitizer‐loaded hydrogels: A new antibacterial dressing DOI
Shunying Liu,

Yanhai Feng,

Tan Yang

et al.

Wound Repair and Regeneration, Journal Year: 2024, Volume and Issue: 32(3), P. 301 - 313

Published: Feb. 3, 2024

Abstract Bacterial wound infection has emerged as a pivotal threat to human health worldwide, and the situation worsened owing gradual increase in antibiotic‐resistant bacteria caused by improper use of antibiotics. To reduce antibiotics avoid bacteria, researchers are increasingly paying attention photodynamic therapy, which uses light produce reactive oxygen species kill bacteria. Treating bacteria‐infected wounds therapy requires fixing photosensitizer (PS) at site maintaining certain level humidity. Hydrogels materials with high water content well suited for PSs sites antibacterial therapy. Therefore, hydrogels often loaded treating via In this review, we systematically summarised mechanisms applications PS‐loaded addition, recent studies research status progresses novel discussed. Finally, challenges future prospects reviewed.

Language: Английский

Peptide Hydrogels as Immunomaterials and Their Use in Cancer Immunotherapy Delivery DOI
Natashya Falcone, Menekşe Ermis, Dilara Goksu Tamay

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(27)

Published: May 31, 2023

Abstract Peptide‐based hydrogel biomaterials have emerged as an excellent strategy for immune system modulation. hydrogels are supramolecular materials that self‐assemble into various nanostructures through interactive forces (i.e., hydrogen bonding and hydrophobic interactions) respond to microenvironmental stimuli pH, temperature). While they been reported in numerous biomedical applications, recently deemed promising candidates improve the efficacy of cancer immunotherapies treatments. Immunotherapies seek harness body's preemptively protect against treat diseases, such cancer. However, their low rates result limited patient responses treatment. Here, immunomaterial's potential these by either functioning stimulators direct interactions and/or delivering a range agents is highlighted. The chemical physical properties peptide‐based lead immuno modulation how one may design achieve desired controllable manner discussed. Works literature reports peptide adjuvant systems delivery Finally, future trends possible developments based on immunotherapy applications

Language: Английский

Citations

24
Liposome–Hydrogel Composites for Controlled Drug Delivery Applications DOI Creative Commons
Roya Binaymotlagh, Farid Hajareh Haghighi, Laura Chronopoulou

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(4), P. 284 - 284

Published: April 22, 2024

Various controlled delivery systems (CDSs) have been developed to overcome the shortcomings of traditional drug formulations (tablets, capsules, syrups, ointments, etc.). Among innovative CDSs, hydrogels and liposomes shown great promise for clinical applications thanks their cost-effectiveness, well-known chemistry synthetic feasibility, biodegradability, biocompatibility responsiveness external stimuli. To date, several liposomal- hydrogel-based products approved treat cancer, as well fungal viral infections, hence integration into has attracted increasing attention because benefit from both them a single platform, resulting in multifunctional formulation, which is essential develop efficient CDSs. This short review aims present an updated report on advancements liposome-hydrogel purposes.

Language: Английский

Citations

14
Recent Advances in Hydrogel-Based Biosensors for Cancer Detection DOI Creative Commons

Shengwei Sun,

Jinju Chen

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(36), P. 46988 - 47002

Published: Aug. 27, 2024

Early cancer detection is crucial for effective treatment, but current methods have limitations. Novel biomaterials, such as hydrogels, offer promising alternatives developing biosensors detection. Hydrogels are three-dimensional and cross-linked networks of hydrophilic polymers that properties similar to biological tissues. They can be combined with various achieve high sensitivity, specificity, stability. This review summarizes the recent advances in hydrogel-based detection, their synthesis, applications, challenges. It also discusses implications future directions this emerging field.

Language: Английский

Citations

12
Recent advances in the design and development of bioink formulations for various biomedical applications DOI Creative Commons

Jiya Jose,

Anmiya Peter,

Kamal Y. Thajudeen

et al.

Results in Engineering, Journal Year: 2024, Volume and Issue: 22, P. 102060 - 102060

Published: April 1, 2024

Creating functioning tissue constructions via bioprinting holds great promise for replacing diseased or damaged tissues, which employs precise control over the geometry and composition of build. This is an emerging technique that offers highly reproducible accurate computerized oversight constructed structures, potentially opening door to high-throughput production. Tissue are made by method using a solution biomaterial combination multiple biomaterials in hydrogel form, known as bioink, often encapsulates appropriate cell types. Hydrogels' aqueous three-dimensional networked environment has them attractive contender bio-ink formulation 3D printing recent times. Bio ink-based composites have however significant progress treating wounds, repairing muscles, bone, tissue, delivering drugs. The current review cutting-edge update on creation various bio ink formulations their uses biomedical industry. methods fabrication—laser-based, extrusion-based, inkjet-based bioprinting—are explained, illustrated, contrasted. Benefits drawbacks every discussed along with approach's difficulties, restrictions, potential future directions. Natural, synthetic, hybrid materials utilized bioinks also examined.

Language: Английский

Citations

9
A comparative study between phenylglycine and phenylalanine derived peptide hydrogels: Towards atomic elucidation DOI
Jolien Bertouille, Ruben Van Lommel, Roy Aerts

et al.

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 44, P. 102593 - 102593

Published: Feb. 27, 2025

Language: Английский

Citations

1
Self-Assembled Materials Based on Fully Aromatic Peptides: The Impact of Tryptophan, Tyrosine, and Dopa Residues DOI Creative Commons
Nicole Balasco, Davide Altamura, Pasqualina Liana Scognamiglio

et al.

Langmuir, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 4, 2024

Peptides are able to self-organize in structural elements including cross-β structures. Taking advantage of this tendency, the last decades, peptides have been scrutinized as molecular for development multivalent supramolecular architectures. In context, different classes peptides, also with completely aromatic sequences, were proposed. Our previous studies highlighted that (FY)3 peptide, which alternates hydrophobic phenylalanine and more hydrophilic tyrosine residues, is self-assemble, thanks formation both polar apolar interfaces. It was observed replacement Phe Tyr residues other noncoded amino acids like 2-naphthylalanine (Nal) Dopa affects interactions among consequences on organization. Herein, we investigated self-assembling behavior two novel analogues Trp place ones, respectively. Additionally, PEGylation N-terminus analyzed too. The organization, morphology, capability gel evaluated using complementary techniques, fluorescence, Fourier transform infrared spectroscopy, scanning electron microscopy. Structural periodicities along perpendicular fiber axis detected by grazing incidence wide-angle X-ray scattering. Finally, dynamics provided interesting insights into atomic structure constitutes basic motif assemblies formed these peptide systems.

Language: Английский

Citations

7
Methods of changing low molecular weight gel properties through gelation kinetics DOI Creative Commons
Rebecca E. Ginesi, Emily R. Draper

Soft Matter, Journal Year: 2024, Volume and Issue: 20(19), P. 3887 - 3896

Published: Jan. 1, 2024

The kinetics of gel formation are known to influence the properties, however structures present before gelation often not discussed or explored. We explore different methods changing pre-processing these change properties final gel.

Language: Английский

Citations

7
Peptide-Based Hydrogels: Template Materials for Tissue Engineering DOI Creative Commons
Roya Binaymotlagh, Laura Chronopoulou, Cleofe Palocci

et al.

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(4), P. 233 - 233

Published: April 19, 2023

Tissue and organ regeneration are challenging issues, yet they represent the frontier of current research in biomedical field. Currently, a major problem is lack ideal scaffold materials’ definition. As well known, peptide hydrogels have attracted increasing attention recent years thanks to significant properties such as biocompatibility, biodegradability, good mechanical stability, tissue-like elasticity. Such make them excellent candidates for 3D materials. In this review, first aim describe main features hydrogel order be considered scaffold, focusing particular on properties, biodegradability bioactivity. Then, some applications tissue engineering, including soft hard tissues, will discussed analyze most relevant trends

Language: Английский

Citations

16
Overview on peptide-based electrochemical biosensors DOI Creative Commons
Gang Liu, Yuanyuan Li, Meiling Liu

et al.

International Journal of Electrochemical Science, Journal Year: 2023, Volume and Issue: 18(12), P. 100395 - 100395

Published: Nov. 1, 2023

Peptides have attracted great interest in the construction of electrochemical biosensors fields biomedicine, disease diagnosis, and environmental monitoring. They exhibit advantages high affinity specificity, chemical diversity building block amino acids, standard synthesis scheme. Versatile peptide-based been developed for detection various targets, including metal ions, enzymes, proteins, exosomes, cells, bacteria. their self-assembled nanostructures can be used as recognition elements, enzyme substrates, electrode materials, signal labels. Different functional species, electroactive small molecules, nanomaterials coupled with peptides direct conversion binding/modification events into measurable signals. Herein, we systematically summarize progress according to difference peptide function target type. The peptide-functionalized molecules amplification strategies improving sensitivity were discussed.

Language: Английский

Citations

16
Dual-Action Therapeutics: DNA Alkylation and Antimicrobial Peptides for Cancer Therapy DOI Open Access
Celia María Curieses Andrés, José Manuel Pérez de la Lastra, Elena Bustamante Munguira

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(18), P. 3123 - 3123

Published: Sept. 10, 2024

Cancer remains one of the most difficult diseases to treat, requiring continuous research into innovative therapeutic strategies. Conventional treatments such as chemotherapy and radiotherapy are effective a certain extent but often have significant side effects carry risk resistance. In recent years, concept dual-acting therapeutics has attracted considerable attention, particularly combination DNA alkylating agents antimicrobial peptides. alkylation, well-known mechanism in cancer therapy, involves attachment alkyl groups DNA, leading damage subsequent cell death. Antimicrobial peptides, on other hand, been shown be anticancer due their ability selectively disrupt membranes modulate immune responses. This review aims explore synergistic potential these two modalities. It examines mechanisms action, current findings, promise they offer improve efficacy specificity treatments. By combining cytotoxic power alkylation with unique properties dual-action may new more approach fighting cancer.

Language: Английский

Citations

6