Unleashing the power of polymeric nanoparticles — Creative triumph against antibiotic resistance: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134977 - 134977

Published: Aug. 24, 2024

Antibiotic resistance (ABR) poses a universal concern owing to the widespread use of antibiotics in various sectors. Nanotechnology emerges as promising solution combat ABR, offering targeted drug delivery, enhanced bioavailability, reduced toxicity, and stability. This comprehensive review explores concepts antibiotic resistance, its mechanisms, multifaceted approaches ABR. The provides an in-depth exploration polymeric nanoparticles advanced delivery systems, focusing on strategies for targeting microbial infections contributing fight against Nanoparticles revolutionize antimicrobial approaches, emphasizing passive active targeting. role molecules, including small peptides, proteins, carbohydrates, stimuli-responsive is being explored recent research works. complex comprehension mechanisms ABR strategic nanotechnology present avenue advancing tactics, ensuring treatment efficacy, minimizing toxic effects, mitigating development Polymeric nanoparticles, derived from natural or synthetic polymers, are crucial overcoming Natural polymers like chitosan alginate exhibit inherent antibacterial properties, while such polylactic acid (PLA), polyethylene glycol (PEG), polycaprolactone (PCL) can be engineered specific effects. study valuable source information researchers, healthcare professionals, policymakers engaged urgent quest overcome

Language: Английский

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Effect of Compositions and Heat Treatments of Polypropylene/PP-g-MAH/CuO-TiO2 Composites on Thermal, Crystallization and Antimicrobial Properties

BioNanoScience, Journal Year: 2024, Volume and Issue: 14(3), P. 2678 - 2690

Published: May 21, 2024

Language: Английский

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Development of novel eco-friendly polyvinyl alcohol-based coating for antibacterial textiles

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2023, Volume and Issue: 680, P. 132719 - 132719

Published: Nov. 4, 2023

Language: Английский

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Effect of Compositions and Heat Treatments of Polypropylene/PP-g- MAH/CuO-TiO2 composites on Thermal, Crystallization and Antimicrobial Properties

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 29, 2024

Abstract The leading cause of increased mortality rates is infections from implanted medical devices, with catheters accounting for more than 80% these infections. Polypropylene (PP) composites antimicrobial properties were developed by adding binary mixed oxide (CuO-TiO 2 ). outcomes demonstrated that the spreading and encapsulation CuO-TiO particles in PP matrix was much better incorporation PP-g-MAH compatibilizer. Matrix crystallinity affected addition compatibilizers, amount , heat treatments. synergy effect as agents analyzed. antibacterial efficacy's reliance on elucidated relation various treatments, compatibilizer, . made oxides (e.g., CuO TiO ) 3 wt% processed a low degree material’s capability effectively rendering plausible species •O 2− •OH − Cu 2+ excellent efficacy towards Escherichia coli ( E. coli) Staphylococcus aureus S. This innovative composite, -PP, offers new perspectives managing bloodstream associated catheter use.

Language: Английский

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Pyridinium‐Yne Click Polymerization: A Facile Strategy toward Functional Poly(Vinylpyridinium Salt)s with Multidrug‐Resistant Bacteria Killing Ability

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(29)

Published: May 2, 2024

Abstract Polymeric materials with antibacterial properties hold great promise for combating multidrug‐resistant bacteria, which pose a significant threat to public health. However, the synthesis of most polymers typically involves complicated and time‐consuming procedures. In this study, we demonstrate simple efficient strategy synthesizing functional poly(vinylpyridinium salt)s via pyridinium‐yne click polymerization. This polymerization could proceed high atom economy under mild conditions without any external catalyst, yielding soluble thermally stable satisfactory molecular weights well‐defined structures in excellent yields. Additionally, incorporation luminescent units such as fluorene, tetraphenylethylene, triphenylamine into polymer backbone confers aggregation‐enhanced emission upon resulting polymers, rendering them suitable bacterial staining. Moreover, existence pyridinium salt imparts intrinsic activity against bacteria enabling effectively inhibit wound infection significantly expedite healing process. work not only provides an method prepare but also opens up possibility various applications healthcare other fields.

Language: Английский

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Pyridinium‐Yne Click Polymerization: A Facile Strategy toward Functional Poly(Vinylpyridinium Salt)s with Multidrug‐Resistant Bacteria Killing Ability

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(29)

Published: May 2, 2024

Abstract Polymeric materials with antibacterial properties hold great promise for combating multidrug‐resistant bacteria, which pose a significant threat to public health. However, the synthesis of most polymers typically involves complicated and time‐consuming procedures. In this study, we demonstrate simple efficient strategy synthesizing functional poly(vinylpyridinium salt)s via pyridinium‐yne click polymerization. This polymerization could proceed high atom economy under mild conditions without any external catalyst, yielding soluble thermally stable satisfactory molecular weights well‐defined structures in excellent yields. Additionally, incorporation luminescent units such as fluorene, tetraphenylethylene, triphenylamine into polymer backbone confers aggregation‐enhanced emission upon resulting polymers, rendering them suitable bacterial staining. Moreover, existence pyridinium salt imparts intrinsic activity against bacteria enabling effectively inhibit wound infection significantly expedite healing process. work not only provides an method prepare but also opens up possibility various applications healthcare other fields.

Language: Английский

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Preparation of a starch derivative bearing chloroaniline groups and the evaluation of its hemolytic, cytotoxic and antibacterial activities

Polymer International, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 5, 2024

Abstract A new starch derivative with antibacterial properties and non‐hemolytic effect was synthesized through the chemical grafting of 4‐chloroaniline onto backbone potato starch. In a first step, extracted from potatoes grown in region Coahuila, Mexico, using water steeping method. The hydroxyl groups (C5‐C6) native were oxidized sodium periodate. resulting dialdehyde then chemically modified Schiff base reaction 4‐chloroaniline. structure this confirmed by Fourier transform infrared 1 H NMR spectroscopies, thermal analyzed thermogravimetric analysis without finding significant changes product showed activity against Gram‐negative E. coli Gram‐positive S. aureus strains. Finally, hemolytic cytotoxic effects its studied, showing no on isolated human red blood cells effect; therefore, it can be considered biocompatible. © 2024 Society Chemical Industry.

Language: Английский

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The Design of a Controlled-Release Polymer of a Phytopharmaceutical Agent: A Study on the Release in Different PH Environments Using the Ultrafiltration Technique

Polymers, Journal Year: 2024, Volume and Issue: 16(24), P. 3492 - 3492

Published: Dec. 14, 2024

A series of hydrophilic copolymers were prepared using 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) from free radical polymerization at different feed monomer ratios ammonium persulfate (APS) initiators in water 70 °C. The herbicide 2,4-dichlorophenoxy acetic (2,4-D) was grafted to Poly(HEMA-co-IA) by a condensation reaction. hydrolysis the polymeric release system, Poly(HEMA-co-IA)-2,4-D, demonstrated that an aqueous phase depends on system’s pH value character. In addition, swelling behavior (Wt%) studied values Liquid-phase Polymer Retention (LPR) ultrafiltration system. conjugates follows first-order kinetic, showing higher kinetic constants as increases. base-catalyzed reaction zero-order where basic medium acts catalyst, accelerating rate differences rates found for hydrogel can be correlated with difference their capacity, generally increases increase capacity solution values. study process revealed all samples distilled 10 are representative agricultural systems. It showed kinetics absorption conforms parameters hydrogels applications, which supports potential these purposes.

Language: Английский

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Antimicrobial, anti‐inflammatory, and antioxidant evaluations of ammonium and phosphonium salts based on poly(vinylbenzyl chloride‐co‐acrylonitrile)

Journal of Applied Polymer Science, Journal Year: 2024, Volume and Issue: 141(34)

Published: June 5, 2024

Abstract Polymers with ammonium or phosphonium salts have been known to possess antimicrobial activity. Herein, synthesis of poly(vinylbenzyl chloride‐ co ‐acrylonitrile) (P(VBC‐ ‐AN)) is reported via a free radical polymerization by employing AIBN as initiator. The copolymer was then quaternized using triethylamine, triphenylphosphine, and tributylphosphine. triphenylphosphonium salt selected for further modification, on which the polyacrylonitrile chains were reacted two different amines: tris (2‐aminoethylamine) diethylenetriamine. copolymerization, quaternization, amination reactions confirmed spectroscopic morphologic analysis besides thermal features. water uptake modified polymers investigated, where tributylphosphonium (KH4) showed highest capacity (41 g/g). assay findings demonstrated that all evaluated copolymers displayed wide range activity against multidrug resistant human pathogens, example polymer coded KH4 containing growth inhibition rates Staphylococcus aureus epidermidis populations, recorded 87% 72%; respectively. anti‐inflammatory revealed protection effect erythrocyte membrane lysis. Antioxidant results 1,1‐diphenyl‐2‐picryl hydrazyl scavenging activities. Among studied copolymers, aminated (KH6) exhibited activity, IC50 ~ 120 μg/mL.

Language: Английский

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Antimicrobial polymers: elucidating the role of functional groups on antimicrobial activity

Arab Journal of Basic and Applied Sciences, Journal Year: 2024, Volume and Issue: 31(1), P. 325 - 344

Published: June 18, 2024

The swift increase in antimicrobial resistance across the world presents a significant challenge, further raised by insufficient advancement design of new agents. Over past two decades, variety sources has been investigated for generating antimicrobials. Recently, polymers (APs) have emerged as multifaceted agents, displaying effectiveness against range pathogens such bacteria, fungi, and viruses. Their notable biocompatibility, efficiency, multifunctionality, ease modification make them focal point research. APs are particularly valued their structural versatility, which allows integration functional groups. Polymer functionalization does not only enhance or introduce properties but also maintains high levels biocompatibility. This review reveals broad breadth APs, can be potentially used antiseptics, food packaging, biomedical sector, e.g. medical implants' coatings. In laboratory settings, shown promising therapeutic effects, however there remains an urgent need computational biology to fully understand behaviour stability. Recombinant biotechnological approaches essential facilitating production require industrial collaboration effectively optimize scale up these processes.

Language: Английский

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