Periodontology 2000,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 19, 2024
Abstract
The
oral
microbiota
develops
within
the
first
2
years
of
childhood
and
becomes
distinct
from
parents
by
4
years‐of‐age.
plays
an
important
role
in
overall
health/symbiosis
individual.
Deviations
state
symbiosis
leads
to
dysbiosis
increased
risk
pathogenicity.
can
occur
not
only
daily
life
activities
but
also
orthodontic
interventions.
Orthodontic
appliances
are
formed
a
variety
biomaterials.
Once
inserted,
they
serve
as
breeding
ground
for
microbial
attachment,
new
surface
areas
crevices
material
physicochemical
interactions
different
than
symbiotic
state.
Individuals
undergoing
treatment
show,
compared
with
untreated
people,
qualitative
quantitative
differences
activity
microbiota,
induced
retention
supra‐
subgingival
plaque
throughout
period.
These
changes
at
root
main
undesirable
effects,
such
gingivitis,
white
spot
lesions
(WSL),
more
severe
caries
lesions.
Notably,
profile
weeks
intervention
might
be
valuable
indicator
predict
identify
higher‐risk
individuals
respect
periodontal
health
otherwise
healthy
population.
Antimicrobial
coatings
have
been
used
dissuade
microbes
adhering
biomaterial;
however,
disrupt
host
several
bacterial
strains
become
resistant.
Smart
biomaterials
that
reduce
antimicrobial
load
preventing
adhesion
shown
promising
results,
their
complexity
has
kept
many
solutions
reaching
clinic.
3D
printing
technology
provides
opportunities
complex
chemical
syntheses
performed
uniformly,
reducing
cost
producing
smart
giving
hope
may
reach
clinic
near
future.
purpose
this
review
is
emphasize
importance
during
therapy
use
innovative
technologies
better
maintain
its
balance
surgical
procedures.
International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 2879 - 2899
Published: March 1, 2025
Introduction:
Periodontitis
is
the
most
common
non-communicable
disease
in
humans.
The
main
challenge
treatment
of
periodontitis
to
effectively
control
periodontal
inflammation
and
promote
tissue
repair.
Human
umbilical
cord
mesenchymal
stem
cells-derived
exosomes
(hucMSCs-exo)
have
been
reported
modulate
inflammatory
responses
repairment
mainly
through
miRNAs
several
diseases.
However,
effect
hucMSCs-exo
on
remains
unknown.
In
this
study,
we
hypothesized
that
could
inhibit
bone
destruction
mice.
Methods:
constructed
characterized
exo@H
drug
delivery
platform.
Lipopolysaccharide
was
used
construct
an
microenvironment
vitro
detect
MC3T3-E1
cells
proliferation
regeneration
capacity.
Ligation
induced
experimental
mouse
model.
distance
cement-enamel
junction
(CEJ)
alveolar
crest
(ABC)
measured
for
resorption
evaluation.
Hematoxylin-eosin
(H&E)
staining
Tartrate
resistant
acid
phosphatase
(TRAP)
were
observe
changes.
MicroRNA
(miRNA)
sequencing
differential
genes
bioinformatics
analysis.
Real-time
quantitative
polymerase
chain
reaction
(qRT-PCR).
WB
assay
dual
luciferase
further
validate
screened
differentially
expressed
targeted
binding
relationship
with
corresponding
target
genes.
Results:
We
found
lyophilized
promoted
osteogenic
differentiation
cells,
showed
more
significant
proliferative
abilities
combination
hydrogel
(
P
<
0.05).
Using
mice,
evaluation
revealed
a
reduction
group
compared
0.01),
able
reduce
response
tissues
number
osteoclasts
surface
group.
Moreover,
59
upregulated,
such
as
let-7f-5p
miR-203-3p,
which
positively
IL-13
Nit2,
respectively.
Discussion:
These
results
suggest
provides
protection
against
partly
by
delivering
tissue.
Our
confirm
feasibility
platform
effectiveness
its
use
treatment,
study
promising
approach
via
miRNA.
Keywords:
periodontitis,
exosomes,
MC3T3-E1,
microRNA,
gene
Journal of Biomaterials Applications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 10, 2025
Oxidative
stress
arises
from
an
imbalance
between
excessive
production
of
reactive
oxygen
species
(ROS)
and
the
body’s
antioxidant
defenses.
In
neurodegenerative
diseases,
this
leads
to
ROS
accumulation,
causing
neuronal
dysfunction
cell
death.
Traditional
drug
therapies
often
fail
address
dynamic
nature
neuroinflammation,
limiting
their
therapeutic
efficacy.
To
overcome
challenge,
we
have
developed
innovative
ROS-responsive
injectable
hydrogel.
This
hydrogel
is
designed
detect
oxidative
sensitively
release
glutathione
in
a
controlled
manner,
thereby
modulating
inflammation
restoring
damaged
immune
microenvironment
facilitate
tissue
repair.
The
was
synthesized
by
crosslinking
polyvinyl
alcohol
(PVA)
with
sodium
alginate
modified
3-aminophenylboronic
acid
(Alg-PBA).
We
investigated
hydrogel’s
formation
mechanism
analyzed
how
component
variations
affect
its
morphological
rheological
properties.
Our
findings
demonstrate
that
optimal
Alg-PBA
PVA
weight
ratio
2:1
yields
superior
mechanical
strength.
Glutathione
(GSH)
studies
confirmed
pronounced
behavior.
Furthermore,
biocompatibility
assessments
revealed
loaded
100
μg/mL
GSH
exhibited
excellent
compatibility
significantly
inhibited
apoptosis
under
oxygen-glucose
deprivation
(OGD)
conditions.
work
presents
promising
strategy
for
treating
inflammation-related
diseases
provides
valuable
insights
designing
next-generation
hydrogels
adapt
injury-responsive
microenvironments.
Frontiers in Oncology,
Journal Year:
2025,
Volume and Issue:
15
Published: April 17, 2025
Melanoma
is
highly
invasive
and
resistant
to
conventional
treatments,
accounting
for
nearly
75%
of
skin
cancer-related
deaths
globally.
Traditional
therapies,
such
as
chemotherapy
immunotherapy,
often
exhibit
limited
efficacy
are
associated
with
significant
side
effects
due
systemic
drug
exposure.
Microneedles
(MNs),
an
emerging
delivery
system,
offer
multiple
advantages,
including
safety,
painlessness,
minimal
invasiveness,
controlled
release.
Among
these,
hydrogel
microneedles
(HMNs)
stand
out
their
extracellular
matrix-like
structure
swelling-induced
continuous
channels,
which
enable
the
direct
therapeutic
agents
into
tumor
microenvironment
(TME).
This
approach
enhances
bioavailability
while
reducing
toxicity,
establishing
HMNs
a
promising
platform
melanoma
treatment.
review
highlights
recent
advancements
in
therapy,
focusing
on
applications
biomarker
extraction
early
diagnosis
role
supporting
multimodal
treatment
strategies,
chemotherapy,
phototherapy,
targeted
combination
therapy.
Furthermore,
current
matrix
materials
fabrication
techniques
discussed.
Finally,
limitations
critically
analyzed,
recommendations
future
research
development
provided.
Journal of Pharmacy and Pharmacology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 30, 2025
This
study
was
executed
to
prepare
and
characterize
quetiapine
(antipsychotic
drug)-loaded
microneedles-based
transdermal
patch
for
improved
drug
delivery.
develop
patches
(MNS)
Eight
MNS
loaded
with
(MNS1-MNS8)
were
fabricated
using
varying
concentrations
of
sodium
alginate
carboxymethyl
cellulose.
First
four
(MNS1,
MNS2,
MNS3,
MNS4)
prepared
by
keeping
concentration
constant
(6%)
increasing
CMC
from
3%
6%,
whereas
MNS5,
MNS6,
MNS7,
MNS8
developed
7:3,
7:4,
8:3,
8:4,
respectively.
Solvent
casting
technique
opted
preparation
patches.
characterized
thickness,
folding
endurance,
insertion
capacity,
content,
morphology,
ex-vivo
permeation
profile
Wistar
rat
skin.
FTIR
studies
revealed
the
compatibility
formulation
composites.
Thickness
endurance
ranged
in
between
0.53-0.55
mm
25-264,
SEM
optimized
showed
sharp
pointed
needles.
Ex-vivo
percent
release
84.34%
MNS1
after
48
h.
The
overall
findings
proposed
that
quetiapine-loaded
hold
promise
delivery
quetiapine.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(14), P. 3336 - 3355
Published: Jan. 1, 2024
Microneedles
that
can
be
inserted
and
attached
to
multiple
organ
sites
are
considered
an
innovative
platform
for
delivering
anti-tumor
drugs,
which
used
in
various
tumor
treatment
protocols.
