Engineering pH and Temperature-Triggered Drug Release with Metal-Organic Frameworks and Fatty Acids DOI Creative Commons
Wanying Wei, Ping Lü

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5291 - 5291

Published: Nov. 8, 2024

This study reports the successful synthesis of core-shell microparticles utilizing coaxial electrospray techniques, with zeolitic imidazolate framework-8 (ZIF-8) encapsulating rhodamine B (RhB) in core and a phase change material (PCM) shell composed eutectic mixture lauric acid (LA) stearic (SA). ZIF-8 is well-recognized for its pH-responsive degradation biocompatibility, making it an ideal candidate targeted drug delivery. The LA-SA PCM mixture, melting point near physiological temperature (39 °C), enables temperature-triggered release, enhancing therapeutic precision. structural properties were extensively characterized through scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), differential calorimetry (DSC), thermogravimetric analysis (TGA). Drug release studies revealed dual-stimuli response, where RhB was significantly influenced by both pH. Under mildly acidic conditions (pH 4.0) at 40 °C, rapid complete observed within 120 h, while 37 rate notably slower. Specifically, °C 79% higher than confirming sensitivity system. Moreover, pH (7.4), minimal occurred, demonstrating system's potential minimizing premature under neutral conditions. approach holds promise improving outcomes cancer treatment enabling precise control over response to localized hyperthermia, reducing off-target effects patient compliance.

Language: Английский

Advances in metal-organic framework-based drug delivery systems DOI

M T Khulood,

U. S. Jijith,

Punnoth Poonkuzhi Naseef

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125380 - 125380

Published: Feb. 1, 2025

Language: Английский

Citations

0
Engineering pH and Temperature-Triggered Drug Release with Metal-Organic Frameworks and Fatty Acids DOI Creative Commons
Wanying Wei, Ping Lü

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5291 - 5291

Published: Nov. 8, 2024

This study reports the successful synthesis of core-shell microparticles utilizing coaxial electrospray techniques, with zeolitic imidazolate framework-8 (ZIF-8) encapsulating rhodamine B (RhB) in core and a phase change material (PCM) shell composed eutectic mixture lauric acid (LA) stearic (SA). ZIF-8 is well-recognized for its pH-responsive degradation biocompatibility, making it an ideal candidate targeted drug delivery. The LA-SA PCM mixture, melting point near physiological temperature (39 °C), enables temperature-triggered release, enhancing therapeutic precision. structural properties were extensively characterized through scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), differential calorimetry (DSC), thermogravimetric analysis (TGA). Drug release studies revealed dual-stimuli response, where RhB was significantly influenced by both pH. Under mildly acidic conditions (pH 4.0) at 40 °C, rapid complete observed within 120 h, while 37 rate notably slower. Specifically, °C 79% higher than confirming sensitivity system. Moreover, pH (7.4), minimal occurred, demonstrating system's potential minimizing premature under neutral conditions. approach holds promise improving outcomes cancer treatment enabling precise control over response to localized hyperthermia, reducing off-target effects patient compliance.

Language: Английский

Citations

0