Efficacy of Three-Dimensional Bioactive Composites in Long Bone Repair with Photobiomodulation DOI Open Access

Santos Júnior,

Letícia Carlucci dos Santos,

Daniela Vieira Buchaim

et al.

Materials, Journal Year: 2025, Volume and Issue: 18(8), P. 1704 - 1704

Published: April 9, 2025

Different treatments have been proposed for morphofunctional bone repair; however, they are not always efficient and limitations. In this experimental study, we present matrix composites with a possible synergistic effect acting scaffolds growth use of photobiomodulation (PBM) to accelerate tissue repair. Thus, the objective was evaluate PBM in repair long (tibia) rats filled biomimetic collagen matrices nanohydroxyapatite heterologous fibrin biopolymer (FB). Forty-eight were distributed into eight groups (n = six each): Blood Clot (BC), + (BCP), Matrix (M), (MP), Fibrin Biopolymer (FB), (FBP), FB (MFB), (MFBP). A 2.0 mm defect created proximal third left tibia. The BCP, MP, FBP, MFBP underwent during surgery maintained twice week until euthanasia at 42 days. Microcomputed tomography (micro-CT), histomorphological histomorphometric analyses performed. Micro-CT analysis revealed that influenced cortical interposition between remnant newly formed bone. Histologically, no exacerbated inflammatory focus or foreign body-type granulomatous reaction observed any group; vast collagenous more oriented thicker spatial conformation PBM-treated groups. Histomorphometrically, showed significantly higher values compared other Specifically, BC group presented mean density 68.33 ± 7.394, while BCP MP 99.83 11.87 99.67 20.58, respectively (p < 0.05). Qualitative fibers indicated enhanced organization maturation This study concluded association bones rats, biopolymer, results contribute improvement growth, together scaffolds.

Language: Английский

Biological Behavior of Bioactive Glasses SinGlass (45S5) and SinGlass High (F18) in the Repair of Critical Bone Defects DOI Creative Commons
Dayane Maria Braz Nogueira, Marcelie Priscila de Oliveira Rosso, Paulo Sérgio da Silva Santos

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 112 - 112

Published: Jan. 13, 2025

This study evaluated the osteogenic potential of bioactive glasses SinGlass (45S5) and High (F18) in regenerating critical bone defects rat calvaria. Both biomaterials promoted new formation around particles, with group exhibiting a higher rate maturation. Histomorphological birefringence analyses revealed better organization newly formed biomaterial-treated groups, immunohistochemistry indicated expression markers such as osteocalcin, immunostaining for morphogenetic protein 2 (BMP 2), 4 4). Microtomography computadorized (Micro-CT) centripetal both greater integration particles into surrounding tissue. The superior performance was attributed to its potassium magnesium content, which enhance osteoconductivity. After 42 days, showed highest percentage formation, line previous studies. Although our results are promising, limited follow-up period use single animal model highlight need further research validate clinical applicability. appears be viable alternative autografts repair, improve tissue accelerate recovery.

Language: Английский

Citations

0
Efficacy of Three-Dimensional Bioactive Composites in Long Bone Repair with Photobiomodulation DOI Open Access

Santos Júnior,

Letícia Carlucci dos Santos,

Daniela Vieira Buchaim

et al.

Materials, Journal Year: 2025, Volume and Issue: 18(8), P. 1704 - 1704

Published: April 9, 2025

Different treatments have been proposed for morphofunctional bone repair; however, they are not always efficient and limitations. In this experimental study, we present matrix composites with a possible synergistic effect acting scaffolds growth use of photobiomodulation (PBM) to accelerate tissue repair. Thus, the objective was evaluate PBM in repair long (tibia) rats filled biomimetic collagen matrices nanohydroxyapatite heterologous fibrin biopolymer (FB). Forty-eight were distributed into eight groups (n = six each): Blood Clot (BC), + (BCP), Matrix (M), (MP), Fibrin Biopolymer (FB), (FBP), FB (MFB), (MFBP). A 2.0 mm defect created proximal third left tibia. The BCP, MP, FBP, MFBP underwent during surgery maintained twice week until euthanasia at 42 days. Microcomputed tomography (micro-CT), histomorphological histomorphometric analyses performed. Micro-CT analysis revealed that influenced cortical interposition between remnant newly formed bone. Histologically, no exacerbated inflammatory focus or foreign body-type granulomatous reaction observed any group; vast collagenous more oriented thicker spatial conformation PBM-treated groups. Histomorphometrically, showed significantly higher values compared other Specifically, BC group presented mean density 68.33 ± 7.394, while BCP MP 99.83 11.87 99.67 20.58, respectively (p < 0.05). Qualitative fibers indicated enhanced organization maturation This study concluded association bones rats, biopolymer, results contribute improvement growth, together scaffolds.

Language: Английский

Citations

0