Polyhydroxybutyrate as a Novel Biopolymer for Dental Restorative Materials: Biological and Morphological Analysis

Polymers, Journal Year: 2025, Volume and Issue: 17(3), P. 313 - 313

Published: Jan. 24, 2025

Polyhydroxybutyrate (PHB) is a biopolymer produced by bacteria. This study aimed to implement the production process of experimental medical-grade PHB and evaluate its morphology biocompatibility compared conventional resin-based composites (RBCs). raw material was via biological then membrane generated electrospinning specifically for this imaged with Micro-Computed Tomography (Micro-CT) scanning electron microscopy (SEM). MTS assay used assess cytotoxicity other materials. Test groups included two packable resin (Point 4-Kerr, G-aenial anterior-GC), flowable (Filtek Ultimate Flowable-3M ESPE, Nova Compo HF-Imicryl), compomer (Nova Compomer-Imicryl), fissure-sealant (Fissured Plus-Imicryl), (Innovaplast Biotechnology Inc., Eskisehir, Turkey). A control group consisting cells without any test also produced. To perform assay, disc-shaped specimens aforementioned materials were prepared incubated mouse fibroblast (L929) 24 48 h. Micro-CT SEM images revealed homogeneous fibrillary structure PHB. highest cell viability in PHB, Compomer, Fissured Plus after Compomer showed rates at h while RBCs had below 25% (p < 0.05). Considering data structure, from point view, seems promising that might have applications field dental restorative

Language: Английский

---

The Production and Characterization of an Aminolyzed Polyhydroxyalkanoate Membrane and Its Cytocompatibility with Osteoblasts

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 950 - 950

Published: Feb. 18, 2025

Polyhydroxyalkanoates (PHAs), recognized as a medical biomaterial, have been proven to promote cell proliferation and tissue repair. PHA has variety of forms: PHB, PHV, PHHx, PHBHHx, etc. In this study, PHBHHx was selected the precursor fabricate biopolyester films. Specifically, novel type film generated through an ammonolysis cross-linking reaction in conjunction with polyamidoamine dendrimer G2.0 (PAMAM). The properties resultant films were comprehensively evaluated, encompassing surface characteristics, amino group content, water contact angle. drug-loading compatibility osteoblasts also determined. findings revealed that following aminolysis, exhibited enhanced roughness enlarged area. Moreover, aminolysis duration extended, hydrophilicity efficiency significantly augmented. Post-aminolysis, membrane more favorable environment for adhesion osteoblasts. Overall, developed study provides insights materials engineering, especially bone

Language: Английский

---

Polymer-Based Scaffolds as an Implantable Material in Regenerative Dentistry: A Review

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(3), P. 80 - 80

Published: Feb. 24, 2025

Polymer-based scaffolds have emerged as transformative materials in regenerative dentistry, enabling the restoration and replacement of dental tissues through tissue engineering approaches. These scaffolds, derived from natural synthetic polymers, mimic extracellular matrix to promote cellular attachment, proliferation, differentiation. Natural polymers such collagen, chitosan, alginate offer biocompatibility bioactivity, while alternatives like polylactic acid (PLA) polycaprolactone (PCL) provide tunable mechanical properties degradation rates. Recent advancements highlight integration bioactive molecules nanotechnology enhance potential these materials. Furthermore, developing hybrid combining addresses strength challenges, paving way for patient-specific treatments. Innovations 3D bioprinting stimuli-responsive biomaterials are expected refine scaffold design further, improving therapeutic precision clinical outcomes. This review underscores critical role polymer-based advancing focusing on their applications, advantages, limitations.

Language: Английский

---

Bioabsorbable PLA/PHA composite pins for orthopedic applications: In vitro and in vivo study

Journal of Industrial and Engineering Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

---

Special Issue Titled “Advances in Biomass-Based Materials and Their Applications”

Materials, Journal Year: 2025, Volume and Issue: 18(9), P. 1947 - 1947

Published: April 25, 2025

As the world faces a turning point where it is necessary to find effective replacements for oil-based products, new strategies must be pursued [...]

Language: Английский

---