Marine Drugs,
Journal Year:
2022,
Volume and Issue:
20(11), P. 693 - 693
Published: Nov. 3, 2022
Chronic
inflammation
can
extensively
burden
a
healthcare
system.
Several
synthetic
anti-inflammatory
drugs
are
currently
available
in
clinical
practice,
but
each
has
its
own
side
effect
profile.
The
planet
is
gifted
with
vast
and
diverse
oceans,
which
provide
treasure
of
bioactive
compounds,
the
chemical
structures
may
valuable
pharmaceutical
agents.
Marine
organisms
contain
variety
some
have
activity
received
considerable
attention
from
scientific
community
for
development
drugs.
This
review
describes
such
as
well
crude
extracts
(published
during
2010–2022)
echinoderms:
namely,
sea
cucumbers,
urchins,
starfish.
Moreover,
we
also
include
their
structures,
evaluation
models,
activities,
including
molecular
mechanism(s)
these
compounds.
paper
highlights
potential
applications
those
marine-derived
compounds
industry
to
develop
leads
pipeline.
In
conclusion,
this
serve
well-documented
reference
research
progress
on
echinoderms
against
various
chronic
inflammatory
conditions.
Antibiotics,
Journal Year:
2021,
Volume and Issue:
10(3), P. 318 - 318
Published: March 19, 2021
Alkaloids
are
nitrogen-containing
heterocyclic
compounds
typically
isolated
from
plants.
They
represent
one
of
the
most
important
types
natural
products
because
their
large
number
and
structural
diversity
complexity.
Based
on
chemical
core
structures,
alkaloids
classified
as
isoquinolines,
quinolines,
indoles,
piperidine
alkaloids,
etc.
In-depth
analyses
have
revealed
antibacterial
activities.
To
date,
due
to
widespread
use
antibiotics,
problem
drug-resistant
bacterial
infections
has
been
gradually
increasing,
which
severely
affects
clinical
efficacy
therapies
patient
safety.
Therefore,
significant
research
efforts
focused
they
a
potentially
new
type
antibiotic
with
wide
spectrum,
rare
adverse
reactions,
low
tendency
produce
drug
resistance.
Their
main
mechanisms
include
inhibition
cell
wall
synthesis,
change
in
membrane
permeability,
metabolism,
nucleic
acid
protein
synthesis.
This
article
reviews
recent
reports
about
structures
activities
alkaloids.
The
purpose
is
solve
resistance
provide
certain
theoretical
basis
ideas
for
development
drugs.
Food Production Processing and Nutrition,
Journal Year:
2022,
Volume and Issue:
4(1)
Published: Oct. 13, 2022
Abstract
Seaweed
has
emerged
as
one
of
the
most
promising
resources
due
to
its
remarkable
adaptability,
short
development
period,
and
resource
sustainability.
It
is
an
effective
breakthrough
alleviate
future
crises.
Algal
have
reached
a
high
stage
growth
in
past
years
increased
output
demand
for
seaweed
worldwide.
Several
aspects
global
farming
production
processing
over
last
20
are
reviewed,
such
latest
situation
approaches
farming.
Research
progress
trend
various
application
discussed.
Besides,
challenges
faced
by
also
analyzed,
related
countermeasures
proposed,
which
can
provide
advice
processing.
The
primary
products,
extraction
application,
or
waste
utilization
would
bring
greater
benefits
with
continuous
improvement
applications
fields.
Graphical
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 541 - 569
Published: Jan. 1, 2024
Natural
products
have
proven
to
significant
curative
effects
and
are
increasingly
considered
as
potential
candidates
for
clinical
prevention,
diagnosis,
treatment.
Compared
with
synthetic
drugs,
natural
not
only
diverse
structures
but
also
exhibit
a
range
of
biological
activities
against
different
disease
states
molecular
targets,
making
them
attractive
development
in
the
field
medicine.
Despite
advancements
use
purposes,
there
remain
obstacles
that
hinder
their
full
potential.
These
challenges
include
issues
such
limited
solubility
stability
when
administered
orally,
well
short
durations
effectiveness.
To
address
these
concerns,
nano-drug
delivery
systems
emerged
promising
solution
overcome
barriers
faced
application
products.
offer
notable
advantages,
large
specific
surface
area,
enhanced
targeting
capabilities,
ability
achieve
sustained
controlled
release.
Extensive
vitro
vivo
studies
provided
further
evidence
supporting
efficacy
safety
nanoparticle-based
delivering
preclinical
models.
This
review
describes
limitations
product
applications
current
status
combined
nanotechnology.
The
latest
advances
from
three
aspects:
connecting
warheads,
self-assembly,
co-delivery.
Finally,
translation
nano-drugs
discussed.
Marine Drugs,
Journal Year:
2020,
Volume and Issue:
18(7), P. 347 - 347
Published: July 1, 2020
Beyond
their
significant
contribution
to
the
dietary
and
industrial
supplies,
marine
algae
are
considered
be
a
potential
source
of
some
unique
metabolites
with
diverse
health
benefits.
The
pharmacological
properties,
such
as
antioxidant,
anti-inflammatory,
cholesterol
homeostasis,
protein
clearance
anti-amyloidogenic
potentials
algal
endorse
protective
efficacy
against
oxidative
stress,
neuroinflammation,
mitochondrial
dysfunction,
impaired
proteostasis
which
known
implicated
in
pathophysiology
neurodegenerative
disorders
associated
complications
after
cerebral
ischemia
brain
injuries.
As
was
evident
various
preclinical
studies,
compounds
conferred
neuroprotection
wide
range
neurotoxic
stressors,
oxygen/glucose
deprivation,
hydrogen
peroxide,
glutamate,
amyloid
β,
or
1-methyl-4-phenylpyridinium
(MPP+)
and,
therefore,
hold
therapeutic
promise
for
disorders.
While
number
promising
neuroprotective
capacity
have
been
identified
over
last
decades,
few
them
had
access
clinical
trials.
However,
recent
approval
an
oligosaccharide,
sodium
oligomannate,
treatment
Alzheimer’s
disease
enlightened
future
algae-based
drug
discovery.
In
this
review,
we
briefly
outline
diseases
injuries
identifying
targets
intervention,
then
review
literature
on
along
underlying
mechanism,
present
appraisal
advances.
We
also
propose
rational
strategy
facilitate
metabolites-based
development.
Phytochemistry Reviews,
Journal Year:
2022,
Volume and Issue:
22(6), P. 1509 - 1540
Published: July 1, 2022
Abstract
Macroalgae
have
been
recently
used
for
different
applications
in
the
food,
cosmetic
and
pharmaceutical
industry
since
they
do
not
compete
land
freshwater
against
other
resources.
Moreover,
highlighted
as
a
potential
source
of
bioactive
compounds.
Red
algae
(Rhodophyta)
are
largest
group
seaweeds,
including
around
6000
species,
thus
it
can
be
hypothesized
that
Sulfated
polysaccharides,
mainly
agar
carrageenans,
most
relevant
exploited
compounds
red
algae.
Other
molecules
essential
fatty
acids,
phycobiliproteins,
vitamins,
minerals,
secondary
metabolites.
All
these
demonstrated
to
exert
several
biological
activities,
among
which
antioxidant,
anti-inflammatory,
antitumor,
antimicrobial
properties
highlighted.
Nevertheless,
need
further
tested
on
vivo
experiments
go
in-depth
study
mechanism
action
specific
understanding
structure–activity
relation.
At
last,
extraction
technologies
correct
isolation
molecules,
cost-effective
way,
facilitate
scale-up
processes
their
application
by
industry.
This
manuscript
is
aimed
at
describing
fundamental
composition
studied
pave
way
utilization
this
underused
resource.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: June 2, 2022
The
increasing
and
widespread
application
of
antibacterial
drugs
makes
antibiotic
resistance
a
prominent
growing
concern
in
clinical
practice.
emergence
multidrug-resistant
bacteria
presents
global
threat.
However,
the
development
use
novel
agents
involves
time-consuming
costly
challenges
that
may
lead
to
yet
further
drug
resistance.
More
recently,
researchers
have
turned
traditional
Chinese
medicine
stem
rise
pathogens.
Many
studies
shown
medicines
significant
bacteriostatic
bactericidal
effects,
with
advantage
low
Some
which
when
combined
antibiotics,
also
demonstrated
activity
by
synergistic
effect.
Traditional
has
variety
active
components,
including
flavonoids,
alkaloids,
phenols,
quinones,
can
inhibit
growth
drug-resistant
be
used
combination
antibiotics
treat
various
bacterial
infections.
We
reviewed
interaction
between
ingredients
antibiotic-resistant
bacteria.
At
present,
flavonoids
alkaloids
are
been
most
widely
studied,
against
show
its
antimicrobial
on
bacteria,
enhance
susceptibility
potentially
reduce
required
dosage
rate
Our
results
provide
direction
for
finding
developing
alternative
methods
counteract
offering
new
therapeutic
strategy
tackling
Global Challenges,
Journal Year:
2023,
Volume and Issue:
7(5)
Published: April 8, 2023
Abstract
The
potential
of
seaweed
to
mitigate
methane
is
real
and
studies
with
red
seaweeds
have
found
reductions
in
produced
from
ruminants
fed
the
region
60–90%
where
active
compound
responsible
for
this
bromoform.
Other
brown
green
observed
production
between
20
45%
vitro
10%
vivo.
Benefits
feeding
are
specific
animal
species‐dependent.
In
some
instances,
positive
effects
on
milk
performance
selected
while
other
note
traits.
A
balance
reducing
maintaining
health
food
quality
necessary.
Seaweeds
a
source
essential
amino
acids
minerals
however,
offer
huge
use
as
feeds
maintenance
once
formulations
doses
correctly
prepared
administered.
negative
aspect
feed
currently
cost
associated
wild
harvest
indeed
aquaculture
improvements
must
be
made
here
if
ingredients
used
solution
control
continued
animal/ruminant
sourced
proteins
future.
This
review
collates
information
concerning
different
how
they
their
constituents
can
reduce
ensure
sustainable
ruminant
an
environmentally
beneficial
manner.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(7), P. 4818 - 4828
Published: March 18, 2022
Machine
learning
(ML)
profoundly
improves
the
accuracy
of
fast
DU8+
hybrid
density
functional
theory/parametric
computations
nuclear
magnetic
resonance
spectra,
allowing
for
high
throughput
in
silico
validation
and
revision
complex
alkaloids
other
natural
products.
Of
nearly
170
surveyed,
35
structures
are
revised
with
next-generation
ML-augmented
DU8
method,
termed
DU8ML.
