Marine Animal Co-Products—How Improving Their Use as Rich Sources of Health-Promoting Lipids Can Foster Sustainability

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(2), P. 73 - 73

Published: Jan. 30, 2024

Marine lipids are recognized for their-health promoting features, mainly being the primary sources of omega-3 fatty acids, and therefore critical human nutrition in an age when global supply these nutrients is experiencing unprecedent pressure due to ever-increasing demand. The seafood industry originates a considerable yield co-products worldwide that, while already explored other purposes, remain mostly undervalued as sustainable healthy lipids, often low-value oil production. These especially appealing lipid since, besides well-known nutritional upside marine animal fat, which particularly rich polyunsaturated they also have interesting bioactive properties, may garner them further interest, not only food, but high-end applications. Besides added value that represent valuable sources, there obvious ecological reducing waste. In this sense, repurposing bioresources will contribute more use strain on heavily depleted stocks. Therefore, untapping potential aligns with both health environmental goals by guaranteeing additional eco-conscious practices.

Language: Английский

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Application of Marine Natural Products against Alzheimer’s Disease: Past, Present and Future

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(1), P. 43 - 43

Published: Jan. 5, 2023

Alzheimer’s disease (AD), a neurodegenerative disease, is one of the most intractable illnesses which affects elderly. Clinically manifested as various impairments in memory, language, cognition, visuospatial skills, executive function, etc., symptoms gradually aggravated over time. The drugs currently used clinically can slow down deterioration AD and relieve but cannot completely cure them. are mainly acetylcholinesterase inhibitors (AChEI) non-competitive N-methyl-D-aspartate receptor (NDMAR) antagonists. pathogenesis inconclusive, it often associated with expression beta-amyloid. Abnormal deposition amyloid hyperphosphorylation tau protein brain have been key targets for past, current, future drug development disease. At present, researchers paying more attention to excavate natural compounds be effective against other pathologies. Marine products demonstrated prospective candidates these compounds, some presented significant neuroprotection functions. Consequently, we intend describe potential effect bioactive derived from marine organisms, including polysaccharides, carotenoids, polyphenols, sterols alkaloids candidates, further discover novel efficacious AD.

Language: Английский

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Toward the Circular Economy in the Aquaculture Sector: Bibliometric, Network and Content Analyses

Sustainability, Journal Year: 2024, Volume and Issue: 16(13), P. 5405 - 5405

Published: June 25, 2024

This paper offers an overview of circular economy strategies applied to the aquaculture sector. The growing challenges imposed on sector by Green Deal impose new growth in name sustainability. scalability these is increasingly hampered regulatory voids and absence a universally accepted assessment method for measuring impacts current systems. More than ever, review knowledge field required comprehend where heading, order make transition. present proposes bibliometric analysis, network analysis content which highlight very expanding research. studies were firstly analyzed from micro (animal metabolism) macro perspective (policies, markets society), emphasizing research still lacking. Furthermore, second level classification concerns type circularity approach proposed system, can be divided into open-loop or closed-loop strategies. Regarding open-loop-related studies, focus evaluation devoted different bioeconomic values biological flows entering exiting system. literature offered insights identification threads that are developing around

Language: Английский

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Marine Fish-Derived Lysophosphatidylcholine: Properties, Extraction, Quantification, and Brain Health Application

Molecules, Journal Year: 2023, Volume and Issue: 28(7), P. 3088 - 3088

Published: March 30, 2023

Long-chain omega-3 fatty acids esterified in lysophosphatidylcholine (LPC-omega-3) are the most bioavailable acid form and considered important for brain health. Lysophosphatidylcholine is a hydrolyzed phospholipid that generated from action of either phospholipase PLA1 or PLA2. There two types LPC; 1-LPC (where at sn-2 position acylated) 2-LPC sn-1 acylated). The type more highly to than type. Given biological health aspects LPC types, it understand structure, properties, extraction, quantification, functional role, effect processing LPC. This review examines various involved characterization, quantification Further, effects methods on potential roles wellbeing discussed. DHA-rich-LysoPLs, including LPC, can be enzymatically produced using lipases phospholipases wide microbial strains, highest yields were obtained by Lipozyme RM-IM®, TL-IM®, Novozym 435®. Terrestrial-based phospholipids generally contain lower levels long-chain PUFAs, therefore, they less effective providing same benefits as marine-based Processing (e.g., thermal, fermentation, freezing) reduces PL fish. containing PUFA, mainly DHA (C22:6 omega-3) eicosapentaenoic EPA (C20:5 play role development neuronal cell growth. Additionally, have been implicated supporting treatment programs depression Alzheimer’s. These activities appear facilitated acute function major facilitator superfamily domain-containing protein 2 (Mfsd2a), expressed BBB endothelium, chief transporter LPC-DHA uptake brain. LPC-based delivery systems also provide opportunity improve properties some bioactive compounds during storage absorption. Overall, LPCs great improving health, but their safety potentially negative should taken into consideration.

Language: Английский

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Production, Transport, Fate and Effects of Lipids in the Marine Environment

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(2), P. 52 - 52

Published: Jan. 21, 2025

Lipids form energy storage depots, cellular barriers and signaling molecules. They are generated metabolized by enzymes under the influence of biotic abiotic factors, some—the long-chain polyunsaturated ω3 ω6 fatty acids cholesterol—are essential for optimal health in marine organisms. In addition, lipids have direct indirect roles control buoyancy fauna ranging from copepods to whales. Phytoplankton account about half planet’s carbon fixation, that goes into lipids. an important component ocean’s ability sequester away atmosphere through sinking especially after transfer zooplankton. main suppliers (PUFAs) environment. also supply cholesterol many phytosterols ocean ecosystems; however, genomics is indicating members Cnidaria, Rotifera, Annelida, Mollusca phyla endogenous capacity de novo synthesis PUFAs as well phytosterols. It has been predicted will decrease organisms with climate change, implications human consumption sequestration; responses PUFA future conditions likely be quite diverse.

Language: Английский

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Supplementation of medium-chain triglycerides combined with docosahexaenoic acid improves cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 378, P. 263 - 270

Published: March 3, 2025

Language: Английский

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Comparative analysis of the impact of large yellow croaker roe phospholipids on the gut microbiota community structure in normal-diet mice

Food Science of Animal Products, Journal Year: 2025, Volume and Issue: 3(2), P. 9240114 - 9240114

Published: April 8, 2025

Language: Английский

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The Rare Marine Bioactive Compounds in Neurological Disorders and Diseases: Is the Blood-Brain Barrier an Obstacle or a Target?

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(7), P. 406 - 406

Published: July 18, 2023

The blood-brain barrier (BBB) is a dynamic separating neurocytes and brain tissues from blood that extremely sealed strictly regulated by transporters such as aquaporin-4 (AQP-4), glucose transporter (GLUT), specialized tight junctional complexes (TJCs) including junctions (TJs), adherens (AJs), Zonulae occludens (ZOs). With specifically selective transcellular paracellular permeability, the BBB maintains homeostatic microenvironment to protect central nervous system (CNS). In recent years, increasing attention has been paied importance of disruption dysfunction in pathology neurological disorders diseases, Alzheimer’s diseases (AD), Parkinson (PD), stroke cerebral edema. However, further research on how integral structure function are altered under physiological or pathological conditions still needed. Focusing ultrastructural features combining latest associated proteins transporters, regulation change were elucidated. By summarizing protective effects known bioactive compounds derived marine life BBB, this review aims highlight key treatment several major instead normally described obstacle drug absorption transport. Overall, BBB’s morphological characteristics their provide theoretical basis for study inspire diagnosis therapy diseases.

Language: Английский

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Microbial production of docosahexaenoic acid (DHA): biosynthetic pathways, physical parameter optimization, and health benefits

Archives of Microbiology, Journal Year: 2023, Volume and Issue: 205(9)

Published: Aug. 29, 2023

Language: Английский

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Docosahexaenoic Acid-Loaded Nanostructured Lipid Carriers for the Treatment of Peri-Implantitis in Rats

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 1872 - 1872

Published: Jan. 18, 2023

Being the most common cause of implant failure, peri-implantitis is defined as a pathological condition associated with occurrence peri-implant plaque, characterized by mucosal inflammation and progressive loss supporting bone tissue attributed to persistence pro-inflammatory cytokines. Docosahexaenoic acid (DHA), which type omega-3 polyunsaturated fatty acid, generally used for treatment many inflammatory diseases. However, suitable form dosing its therapeutic effect on remain unclear. In this study, novel nanostructured lipid carrier (NLC) loaded squalene DHA was fabricated (DHA-loaded NLC). The encapsulation efficiency drug loading values DHA-loaded NLC were 78.13% ± 1.85% 28.09% 0.48%, respectively. release gradual steady until 144 h. addition, free-radical-scavenging rate (0.57 0.03) much higher than that sole (0.17 0.003). By inhibiting nuclear factor-κB p65 translocation, prevented activation downstream pathways exerted anti-inflammatory effects macrophages. Moreover, showed better preventing alveolar resorption rat model DHA. Hence, enhanced bioavailability DHA, offering approach peri-implantitis.

Language: Английский

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