A Survey of Recently Discovered Naturally Occurring Organohalogen Compounds

Journal of Natural Products, Journal Year: 2024, Volume and Issue: 87(4), P. 1285 - 1305

Published: Feb. 20, 2024

The discovery of naturally occurring organohalogen compounds has increased astronomically in the 55 years since they were first discovered─from fewer than 50 1968 to a combined 7,958 described examples three comprehensive reviews. present survey, which covers period 2021–2023, brings number known natural organohalogens approximately 8,400. organization is according species origin, and coverage includes marine terrestrial plants, fungi, bacteria, sponges, corals, cyanobacteria, tunicates, other organisms.

Language: Английский

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Structures and Biological Activities of Secondary Metabolites from the Trichoderma genus (Covering 2018–2022)

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(37), P. 13612 - 13632

Published: Sept. 8, 2023

Trichoderma, a genus with more than 400 species, has long history of use as an industrial bioreactor, biofertilizer, and biocontrol agent. It is considered significant source secondary metabolites (SMs) that possess unique structural features wide range bioactivities. In recent years, numerous including terpenoids, polyketides, peptides, alkaloids, steroids, have been identified. Most these SMs displayed antimicrobial, cytotoxic, antifungal effects. This review focuses on the diversity, biological activities, structure–activity relationships (SARs) isolated from Trichoderma covered 2018 to 2022. study provides insights into exploration utilization bioactive compounds species in agriculture or pharmaceutical industry.

Language: Английский

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Exploration and Evaluation of Secondary Metabolites from Trichoderma harzianum: GC-MS Analysis, Phytochemical Profiling, Antifungal and Antioxidant Activity Assessment

Molecules, Journal Year: 2023, Volume and Issue: 28(13), P. 5025 - 5025

Published: June 27, 2023

In this study, we investigated in vitro the potential of Trichoderma harzianum to produce bioactive secondary metabolites that can be used as alternatives synthetic compounds. The study focused on analyzing two extracts T. using ethyl acetate and n-butanol solvents with different polarities. were examined phytochemical analysis determine content polyphenols, flavonoids, tannins, alkaloids. Thin-layer chromatography (TLC) Gas chromatography-mass spectroscopy (GC-MS) profile volatile organic (VOCs) present extracts. Furthermore, tested for their antifungal ability poison food technique. For measuring antioxidant activity, 1,1-diphenyl-2-picryl-hydrazyl (DPPH) test was used. shown have a significantly high tannins alkaloids, noticeable difference between GC-MS identified 33 compounds numerous benefits could agriculture medicinal industry. Moreover, strong activity against Sclerotinia sclerotiorum by 94.44%, Alternaria sp. 77.04%, Fusarium solani 51.48; similarly, IC50 estimated extract 71.47% 56.01%. This leads conclusion VOCs play significant role an agent when taking into account advantageous chemicals noted However, our knowledge, is first Algeria presenting detailed profiling extracts, n-butanol.

Language: Английский

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Marine natural products for biofouling elimination in marine environments

Biocatalysis and Agricultural Biotechnology, Journal Year: 2024, Volume and Issue: unknown, P. 103385 - 103385

Published: Sept. 1, 2024

Language: Английский

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Fungal Metabolites as Crop Pathogen Controllers

Fungal biology, Journal Year: 2025, Volume and Issue: unknown, P. 105 - 135

Published: Jan. 1, 2025

Language: Английский

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Exploring the Potential Benefits of Trichoderma Species in Agro-Industrial Crop Production

Published: Jan. 1, 2025

Language: Английский

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Coffee husk valorization through choline chloride/lactic acid (1:10) green catalyst extraction for lignin monomers recovery

Environmental Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: March 4, 2025

The processing of coffee consists on the separation grains from other parts fruit, then roasted and extracted to obtain beverage that is so appreciated worldwide. Several studies have dedicated efforts treat residue processing, while recovering lignols industrial interest. Given this scenario, nutrients in husk can enhance microbial growth, providing optimal conditions for microorganisms produce metabolites may medicinal properties. Deep eutectic solvents (DES) are a class and/or catalysts designed demand specific uses, being used extraction processes husk. Our present study was successful establishing where enhanced growth two Brazilian biomes, endophytic fungus Cerrado actinomycete, Atlantic Rainforest Boraceia, São Paulo. DES composed by ChCl/LA (1:10) selected as cosolvent extraction, it also optimized cultivation conditions. Coffee an excellent supplement culture media, once FE316 produced Fumiquinazoline A, Tripprostatin B Pseurotin actinomycete AC154 Trichorozin-IV only expressed when addition UHPLC-MS/MS analysis enabled annotation lignin monomer compounds, such alkaloids, phenylpropanoids terpenoids husk, more specifically, caffeic acid, isochlorogenic acid B, chlorogenic coniferyl aldehyde, underscoring value biomass.

Language: Английский

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Synergistic effects of Trichoderma and biochar on the biocontrol of two soil-borne phytopathogens in chickpeas

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: May 1, 2025

Introduction This study aims to identify and characterize four Trichoderma isolates using molecular techniques, Fourier transform infrared spectroscopy (FTIR), volatile organic compounds (VOC) profiling. Methods The antagonistic activity of these was assessed against Fusarium oxysporum f. sp. ciceri (FOC) Sclerotium rolfsii (SR) a dual culture technique. synergistic effect harzianum (accession no. PP256488) combined with biochar (BC) evaluated for plant growth enhancement disease suppression. Four ( T. harzianum, asperellum, virens , lixii ) were identified through ITS region analysis, VOC profiling, FTIR spectroscopy. Results Molecular analysis confirmed their distinct identities, GC-MS revealed 37 VOCs out 162 antipathogenic properties. Unique peaks recorded at 3271.96 cm −1 2800–2900 asperellum 2850–2950 both . Scanning electron microscopy (SEM) mycoparasitic structures, including hyphal coils, penetration holes, appressoria, indicating effective pathogen interaction. application (T9) significantly enhanced root length (9.23 cm), height (26.03 mass (43.33 g) in chickpea plants. Moreover, treatments (T10) reduced the incidence chickpeas, decreasing fusarium wilt by 27% collar rot 33%, respectively. Conclusion sustainable approach exhibits potential which can enhance reduce incidence, improve food security.

Language: Английский

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The Polyketides with Antimicrobial Activities from a Mangrove Endophytic Fungus Trichoderma lentiforme ML-P8-2

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(11), P. 566 - 566

Published: Oct. 28, 2023

Five new polyketides, including two chromones (1-2), phenyl derivatives (4-5), and a tandyukusin derivative (6), along with five known polyketides (3 7-10) were isolated from mangrove endophytic fungus Trichoderma lentiforme ML-P8-2. The planar structures of compounds elucidated via detailed 1D, 2D NMR, HR-ESI-MS analysis. ECD spectra, optical rotation values calculation, alkali hydrolysis applied in the determination absolute configuration compounds. In bioassays, 6 9 exhibited promising antifungal activities against Penicillium italicum, an MIC value 6.25 μM for both Moreover, 3 displayed moderate AChE inhibitory activity IC50 20.6 ± 0.3 μM.

Language: Английский

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Increasing the tolerance of Trichoderma harzianum T-22 to DMI fungicides enables the combined utilization of biological and chemical control strategies against plant diseases

Biological Control, Journal Year: 2024, Volume and Issue: 192, P. 105479 - 105479

Published: March 5, 2024

Demethylase inhibitors (DMIs) targeting CYP51 proteins in fungi are often used for plant disease management. Trichoderma harzianum, a widely biocontrol agent, however, is sensitive to DMIs. This negates their combined use as strategy practices. Increasing the tolerance of T. harzianum DMIs represents feasible solution this problem. In regard, overexpression CYP51B variant Mycosphaerella graminicola (MgCYP51B-v) conveys increased Molecular docking indicated distinct decrease affinity MgCYP51B-v with Since conserved M. and we attempted increase DMI by heterologously expressing MgCYP51B-v. A series mutants were obtained that able develop colonies on tebuconazole-amended medium. Two representative selected further studies confirmed they resistant tebuconazole resistance factors (RFs) approximately 10.0. The maintained similar level after ten rounds subculture without fungicide, indicating fungicide was stably inherited. also exhibited other DMIs, including metconazole, ipconazole, hexaconazole, prochloraz. Further assessment did not have any impact fitness. improved compatibility between enables utilization which these control agents together. Such has potential provide synergistic prevent or delay development resistance.

Language: Английский

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