Regional Studies in Marine Science, Journal Year: 2024, Volume and Issue: unknown, P. 104003 - 104003
Published: Dec. 1, 2024
Language: Английский
Toxicology Research, Journal Year: 2024, Volume and Issue: 13(5)
Published: Sept. 2, 2024
Abstract Background A growing number of findings have focused on the distinctive physiochemical characteristics that marine microorganisms acquired as a result their adaptation to challenging conditions inherent in environment. It has been established environment is very rich source bioactive substances with variety biological effects and structural diversity. major discovery was extraction xyloketals from Xylaria sp. Numerous thorough studies subsequently carried out determine medicinal potential these components. Xyloketals are thought be promising significant class naturally occurring wide range potent activities, such radical scavenging, suppression cell proliferation, reduction neonatal hypoxic-ischemic brain injury, antioxidant activity, inhibition acetylcholine esterase, L-calcium channels, others. Xyloketal B one most molecules therapeutic properties among numerous variants discovered. Conclusion This review summarizes characterization all xyloketal compounds, especially derivative an emphasis bioactivity provides outline how operate diverse disease scenarios.
Language: Английский
Citations
1
Marine Drugs, Journal Year: 2024, Volume and Issue: 22(11), P. 523 - 523
Published: Nov. 20, 2024
Cardiovascular diseases (CVDs), which comprise coronary heart disease, hypertension, and stroke, collectively represent the number one cause of death globally. Atherosclerosis is dominant CVDs, its risk factors are elevated levels low-density lipoprotein cholesterol triglycerides, cigarette smoking, obesity, diabetes mellitus. In addition, diverse evidence highlights role played by inflammation clonal haematopoiesis, eventually leading to immunity involvement. The human microbiota project subsequent studies using next-generation sequencing technology have indicated that thousands different microbial species present in gut. Disturbances gut (GM) composition, i.e., dysbiosis, been associated with ranging from localised gastrointestinal disorders metabolic cardiovascular illnesses. Of note, experimental suggested GM, host immune cells, marine-derived ingredients work together ensure intestinal wall integrity. This review discusses current concerning links among ingredients, inflammatory disease. detail, we summarise impact fish-derived proteins/peptides algae components on CVD microbiome. Furthermore, describe interplay these dietary components, probiotics/prebiotics, CVDs.
Language: Английский
Citations
1
Published: Sept. 22, 2023
Cardiovascular diseases (CVD) remain the leading cause of death across globe, hence, establishing strategies to counteract CVD are imperative reduce mortality and burden on health systems. Dietary modification is an effective primary prevention strategy against CVD. Research regarding dietary supplementation has become increasingly popular. This review focuses current in vivo, vitro, epidemiological studies associated with that omega-3 polyunsaturated fatty acids (n-3 PUFA) polar lipids (PLs) how they play a role Furthermore, this results several major clinical trials examining n-3 PUFA both secondary Notably, we place lens REDUCE-IT STRENGTH trials. Finally, PLs recently been suggested as potential alternative avenue for reduction incidence versus neutral forms PUFA. However, evidence argument currently rather limited. Therefore, draw literature suggest future PL supplementation. We conclude despite conflicting evidence, human must be completed confirm whether may more than cardiovascular risk.
Language: Английский
Citations
2
Marine Drugs, Journal Year: 2024, Volume and Issue: 22(6), P. 275 - 275
Published: June 13, 2024
Cyclic pentapeptide compounds have garnered much attention as a drug discovery resource. This study focused on the characterization and anti-benign prostatic hyperplasia (BPH) properties of avellanin A from Aspergillus fumigatus fungus in marine sediment samples collected Beibu Gulf Guangxi Province China. The antiproliferative effect molecular mechanism were explored testosterone propionate (TP)-induced RWPE-1 cells. transcriptome results showed that significantly blocked ECM–receptor interaction suppressed downstream PI3K-Akt signalling pathway. Molecular docking revealed has good affinity for cathepsin L protein, which is involved terminal degradation extracellular matrix components. Subsequently, qRT-PCR analysis expression genes COL1A1, COL1A2, COL5A2, COL6A3, MMP2, MMP9, ITGA2, ITGB3 was downregulated after intervention. Western blot also confirmed it not only reduced FAK/p-FAK protein but inhibited PI3K/p-PI3K Akt/p-Akt Furthermore, Cyclin D1 upregulated Bax, p21WAF1/Cip1, p53 proapoptotic TP-induced cells, leading to cell cycle arrest inhibition proliferation. this support use potential new treatment BPH.
Language: Английский
Citations
0
Sustainable Chemistry and Pharmacy, Journal Year: 2024, Volume and Issue: 42, P. 101742 - 101742
Published: Aug. 29, 2024
Language: Английский
Citations
0
Published: Jan. 1, 2024
Language: Английский
Citations
0
Advances in medical technologies and clinical practice book series, Journal Year: 2024, Volume and Issue: unknown, P. 443 - 460
Published: Sept. 25, 2024
The exponential growth of the world population and emergence new diseases demand innovative drug discovery approaches. With 75% Earth's surface covered by water, marine organisms offer untapped potential for development. This chapter reviews drugs candidates from origins, emphasizing opportunities in pharmacology research. Recent years have seen a resurgence natural products, exemplified Ziconotide trabectedin. Traditional knowledge, such as that Kinh people China, underscores medicinal richness ecosystems. Despite concerns about conservation, evidence suggests minimal environmental impact bioprospecting. Sustainable approaches include mandatory collection protocols, assessments, synthesis. Integration conservation efforts with pharmaceutical research ensures therapeutic benefits resources while preserving biodiversity traditional knowledge future generations.
Language: Английский
Citations
0
Advances in medical technologies and clinical practice book series, Journal Year: 2024, Volume and Issue: unknown, P. 339 - 368
Published: Sept. 25, 2024
Cardiovascular diseases are severe global health issues with side effects. Current treatments unclear and can cause Marine carotenoids, found in plants, a promising source for drug discovery due to their biological activities chemical variety. Their physiological actions may prevent degenerative have antioxidant The variety of marine natural products made them an attractive discovery. This review focuses on the specific functions mechanisms these active constituents coronary artery disease, highlighting abilities such as reducing lipid levels, acting antioxidants, inhibiting platelet aggregation, possessing anticoagulant properties. presents challenge food industry, consumers now seek foods that not only nutritious but also convenient pleasurable eat.
Language: Английский
Citations
0
Regional Studies in Marine Science, Journal Year: 2024, Volume and Issue: unknown, P. 104003 - 104003
Published: Dec. 1, 2024
Language: Английский
Citations
0