Penerbit BRIN eBooks, Journal Year: 2023, Volume and Issue: unknown
Published: Dec. 29, 2023
Botanica Marina, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Abstract The present study elucidates the bioactive metabolites, antioxidants, and antibacterial potential of selected seaweeds – Kappaphycus alvarezii , Caulerpa chemnitzia Sargassum tenerrimum collected from southwest coast India. Biomolecules were extracted using six solvents: hexane, dichloromethane, ethyl acetate, acetone, methanol, ethanol. Among these, ethanol proved to be most efficient extraction solvent. Notably, ethanolic extract S . exhibited high phenolic flavonoid contents, contributing its potent antioxidant properties. In contrast, extracts C rich in tannins, demonstrating marked activity. Gas Chromatography-Mass Spectrometry profiling identified approximately 42 compounds with antimicrobial, antioxidant, anticancer, antidiabetic, cardioprotective Key included stigmasta-5, 24(28)-dien-3-ol (3β, 24Z), cholesterol margarate, arachidonic acid, squalene, 1-hexadecanol, δ-tocopherol, all which hold significant nutraceutical cosmetic value. Furthermore, susceptibility tests against nine bacterial strains revealed that K was particularly effective gram-positive bacteria, while showed considerable efficacy both gram-negative strains.
Language: Английский
Citations
0
Discover Plants., Journal Year: 2025, Volume and Issue: 2(1)
Published: March 17, 2025
Language: Английский
Citations
0
Marine Drugs, Journal Year: 2025, Volume and Issue: 23(4), P. 152 - 152
Published: March 31, 2025
Currently, marine algae are still an under-exploited natural bioresource of bioactive compounds. Seaweeds represent a sustainable source for obtaining compounds that can be useful the fabrication new active products with biomedical benefits and applications as biomedicinals nutraceuticals. The objective this review is to highlight scientific papers identify biocompounds from macroalgae emphasize their benefits. method used was data analysis systematize information various in pharmaceuticals, cosmetics, research results demonstrate multiple uses seaweeds. As seaweeds rich sources like polysaccharides, protein compounds, pigments, polyphenols, which have demonstrated pharmacological activities such antioxidant, antibacterial, anti-inflammatory, antiviral, anticoagulant, potentially anticarcinogenic effects. Seaweed has gained recognition functional food offers unique set promote body health, including vitamins, minerals, antioxidants. In conclusion, importance expand possibilities utilizing resources by broadening areas human health
Language: Английский
Citations
0
The Veterinary Journal, Journal Year: 2025, Volume and Issue: unknown, P. 106358 - 106358
Published: April 1, 2025
Antimicrobial resistance is a growing global concern, prompting for antibiotic alternatives in animal production. Seaweed, abundant bioactive compounds with anti-inflammatory properties, offers natural substitute to synthetic compounds. Considering this, the objective of present study was evaluate bioactivity three seaweeds 1:1 combination Ascophyllum nodosum, Palmaria palmata, and Ulva lactuca. Initially, polyphenol, flavonoid, total phlorotannin content seaweed species were assessed through colorimetric assays. Subsequently, first evaluated an inhibition protein precipitation assay then confirmed vitro gene expression assays LPS-stimulated porcine alveolar macrophages (PAMs). The evaluation molecules revealed high TPC (1487.67±40.39 1763.57±69.01mg TAE/100mg sample, respectively), as well TFC (95.68±3.62 126.09±7.34mg CE/100mg sample) TPhC (0.167±0.02 0.23±0.01mg PGE/100mg) AN UL, respectively. inhibiting disclosed that extracts combining two algae (ANUL, ANPP, PPUL) more effective than effect exhibited by each single extract. assessment significant down-regulation IL-1β TNF-α extracts. In contrast, TGF-β showed increasing trend. These findings, along confirmation molecules, highlight algae's potential, making them suitable antibiotics disease prevention livestock sector. Therefore, future research should explore specific validate their efficacy vivo confirm potential use
Language: Английский
Citations
0
Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 112548 - 112548
Published: Dec. 1, 2024
Language: Английский
Citations
3
Aquaculture International, Journal Year: 2023, Volume and Issue: 32(3), P. 2523 - 2548
Published: Sept. 29, 2023
Language: Английский
Citations
7
Informatics in Medicine Unlocked, Journal Year: 2024, Volume and Issue: 49, P. 101539 - 101539
Published: Jan. 1, 2024
A total of 116 metabolites Caulerpa racemosa were identified. However, only three (DHA, EPA, and EPAS) found to have high anti-inflammatory potential, with Pa scores ranging from 0.764 0,827. The inhibition constant (Ki) binding energy interactions COX-2 revealed by DHA (−8.83 kcal/mol: 0.338 μM), EPA (−8.35 0.763 EPAS (−8.05 1.25 μM). They used bind the fundamental residues (TYR 348, VAL 349, LEU 384, TYR 385, TRP 387). result molecular dynamics showed that DHA, had stability while interacting in 310 K. stabilities 1.8 Å for 60 Ns 200 Ns, 2.0 75 2.2 100 Ns. Additionally, potential (−1.069.250 eV) was higher compared (−1.069.247 (−1.069.220 eV). This data shows could stably inhibit blocking transcriptional regulation via TYR348, VAL349, LEU384, TYR385, TRP387.
Language: Английский
Citations
1
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: July 2, 2024
Background The marine environment, with its rich biodiversity and nutrient-dense ecosystems, offers immense potential for discovering novel pharmaceutical products.
Language: Английский
Citations
1
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: July 11, 2024
Abstract Aporosa cardiosperma is a plant species majorly found in the Indian Western Ghats that belongs to phyllanthaceae family with ethnobotanical importance. Using Fourier Transform-Infrared Spectrometer (FT-IR) and Gas Chromatography-Mass Spectrometry (GC–MS) for evaluating leaf extracts of A. , significant functional groups metabolite constituents were determined, its total flavonoid, phenol, tannin content quantified. Further, antibacterial efficacy was investigated against microorganisms cause fish human disease are resistant common antibiotics, including Staphylococcus aureus, Bacillus subtilis, Mycobacterium tuberculosis, Klebsiella pneumoniae Aeromonas hydrophila Pseudomonas aeruginosa . Regarding outcomes GC–MS analysis, primary metabolites heneicosane (57.06%), silane (13.60%), 1-heptadecene (10.09%), 3-hexadecene (9.99%), pentadecane (9.54%). In comparison other solvents, methanolic extract leaves had increased phenolic, content; these findings consistent vitro antioxidant potential obtained (100 µg/mL) exhibited higher percentage inhibition DPPH (82.35%), FRAP (86.20%), metal chelating (72.32%), ABTS (86.06%) assays respectively. Similar regarding pathogenic bacteria. Comparatively, extracts, showed more activity at lower minimum inhibitory concentration (MIC) value (250 µg/mL), whilst ethyl acetate hexane solvent MIC values 500 µg/mL 1000 The antimicrobial validated by investigating bacterial growth through acquired MICs sub-MICs range. Bacterial completely inhibited determined conclusion, extract's phytochemical fingerprint has been potent activities discovered. These current study will pave way developing herbal treatments from various diseases.
Language: Английский
Citations
1
Applied Food Research, Journal Year: 2024, Volume and Issue: unknown, P. 100625 - 100625
Published: Nov. 1, 2024
Language: Английский
Citations
1