Scientific Data,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: April 22, 2024
Natural
products
exhibit
interesting
structural
features
and
significant
biological
activities.
The
discovery
of
new
bioactive
molecules
is
a
complex
process
that
requires
high-quality
metabolite
profiling
data
to
properly
target
the
isolation
compounds
interest
enable
their
complete
characterization.
same
can
also
be
used
better
understand
chemotaxonomic
links
between
species.
This
Data
Descriptor
details
dataset
resulting
from
untargeted
liquid
chromatography-mass
spectrometry
76
natural
extracts
Celastraceae
family.
spectral
annotation
results
related
chemical
taxonomic
metadata
are
shared,
along
with
proposed
examples
reuse.
further
studied
by
researchers
exploring
diversity
products.
serve
as
reference
sample
set
for
deep
metabolome
investigation
this
chemically
rich
plant
Marine Drugs,
Journal Year:
2025,
Volume and Issue:
23(1), P. 33 - 33
Published: Jan. 10, 2025
Echinoderms,
a
diverse
group
of
marine
invertebrates
including
starfish,
sea
urchins,
and
cucumbers,
have
been
recognized
as
prolific
sources
structurally
natural
products.
In
the
past
five
years,
remarkable
progress
has
made
in
isolation,
structural
elucidation,
pharmacological
assessment
these
bioactive
compounds.
These
metabolites,
polysaccharides,
triterpenoids,
steroids,
peptides,
demonstrate
potent
bioactivities
such
anticancer,
anti-inflammatory,
antiviral,
antimicrobial
effects,
providing
valuable
insights
scaffolds
for
drug
discovery.
This
review
highlights
diversity
biological
activities
products
derived
from
echinoderms
over
last
with
particular
focus
on
their
structure–activity
relationships
therapeutic
potential.
It
also
outlines
prospects
challenges
future
research,
aiming
to
stimulate
further
exploration
IntechOpen eBooks,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 20, 2025
The
creation
of
stability-indicating
analytical
methods,
phytoconstituent
identification,
and
validation
for
content
impurity
estimation
in
pharmaceutical
drug
products
substances
using
high-performance
liquid
chromatography
(HPLC),
ultra-performance
(UPLC),
chromatography-mass
spectrometry
(LC-MS),
gas
(GC-MS),
supercritical
fluid
(SFC)
employing
contemporary
techniques
are
the
primary
topics
this
chapter.
intricacy
diversity
herbal
components
provide
most
hurdle.
Effective
methods
thus
crucial
separation
qualitative
quantitative
analysis
multi-component
systems.
Recent
advances
selectivity,
sensitivity,
speed
have
made
a
number
newly
developed
approaches
major
support
complex
component
analysis.
This
chapter
provides
an
overview
application
advanced
identification
natural
medicines.
By
carefully
choosing
refining
both
fixed
mobile
phases,
scope
applications
was
increased.
Synthetic and Systems Biotechnology,
Journal Year:
2025,
Volume and Issue:
10(2), P. 600 - 609
Published: Feb. 5, 2025
Natural
products
(NPs)
are
the
most
precious
pharmaceutical
resources
hidden
in
complex
metabolomes
of
organisms.
However,
MS
signals
NPs
often
numerous
interfering
features
including
those
from
both
abiotic
and
biotic
processes.
Currently,
there
is
no
effective
method
to
differentiate
between
caused
by
processed,
such
as
cellular
degradation
media
components
processed
microbes,
which
result
fruitless
isolation
structural
elucidation
work.
Here,
we
introduce
NP-PRESS,
a
pipeline
remove
irrelevant
chemicals
metabolome
prioritizes
with
aid
two
newly
developed
MS1
MS2
data
analysis
algorithms,
FUNEL
simRank.
The
stepwise
use
simRank
excels
thorough
removal
overwhelming
features,
particularly
processes,
help
reducing
complexity
risk
erroneous
isolations.
As
proof-of-concept,
NP-PRESS
was
applied
Streptomyces
albus
J1074,
fasciliating
identification
new
surugamide
analogs.
Its
performance
further
demonstrated
on
an
unusual
anaerobic
bacterium
Wukongibacter
baidiensis
M2B1,
leading
discovery
family
depsipeptides
baidienmycins,
exhibit
potent
antimicrobial
anticancer
activities.
These
successes
underscore
efficacy
differentiating
uncovering
diverse
microorganisms,
especially
for
extremophiles
bacteria
metabolomes.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
Structural
dereplication
is
an
essential
step
in
the
study
of
natural
products
(NPs).
The
number
discovered
NPs
so
large
that
efficient
highly
desirable.
NMR
spectroscopy
still
gold
standard
for
structural
identification.
13C
spectrum
effective
molecular
fingerprint,
but
their
acquisition
time-consuming,
especially
mass-limited
NPs.
Several
alternative
methods
or
tools
have
been
proposed
never
reached
general
use
some
reasons.
Here,
a
new
artificial
intelligence
tool,
HSQCid,
using
contrastive
learning
between
1H–13C
HSQC
spectra
and
structures,
Two
structure
encoders
are
compared,
graph
neural
network
preferred
over
Transformer.
In
this
way,
80%
20%
about
400,000
predicted
data
could
be
used
training
testing,
respectively.
Besides,
with
17,971
experimental
as
external
test
data,
top-1
top-10
accuracies
reach
74.5%
94.8%,
Top-1
accuracy
increases
by
at
least
12%
when
combined
other
easily
obtainable
features,
such
total
hydrogens
connected
to
carbons
from
1H
spectra.
Further
analysis
shows
filters
features
nearly
eliminate
influence
(>10%)
difference
data.
Surprisingly,
ratio
nonprotonated
on
identification
only
significant
specific
rare
cases
(2.65%).
Furthermore,
benchmark
method,
which
matches
peaks,
compared
markedly
inferior
without
features.
HSQCid
code
available
online.
It
believed
contributes
paving
way
high-throughput
IntechOpen eBooks,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
X-ray
imaging
is
an
important
tool
for
non-destructive
analysis,
providing
insights
into
internal
structures
without
damaging
the
sample.
Traditional
techniques
often
require
high
doses
of
radiation
and
are
not
flexible
enough,
requiring
advanced
methods
that
improve
resolution
while
minimizing
exposure.
This
chapter
examines
state-of-the-art
techniques,
including
fluorescence
(XRF)
elemental
diffraction
(XRD)
powder
(PXRD)
crystal
structure
determination,
absorption
spectroscopy
(XAS),
single
(SCXRD),
emission
(XES),
analyzes
their
applications,
limitations
development
potential
to
advance
field
highlight
transformative
impact
on
scientific
industrial
fields.
Innovative
approaches
such
as
detectors
sophisticated
data
analysis
well
way
revolutionizing
imaging.
Since
its
introduction
in
1890s,
has
been
essential
medical
diagnostics
inspections.
Continuous
optimization
innovation
crucial
further
progress.
Literature
reviews
case
studies
demonstrate
benefits
SCXRD
XES
precise
structural
small-angle
scattering
(SAXS)
provides
valuable
molecular
material
properties.
The
highlights
critical
role
various
fields,
materials
science,
chemistry,
biology,
forensics
quality
control.
Closing
research
gaps
promoting
continuous
improves
understanding
application
technologies.
future
promises
enormous
breakthroughs
numerous
disciplines.
importance
advancing
address
new
challenges.
Applied Microbiology and Biotechnology,
Journal Year:
2025,
Volume and Issue:
109(1)
Published: Feb. 25, 2025
Cancer
is
a
predominant
contributor
to
global
morbidity
and
mortality,
affecting
populations
worldwide.
Marine
Micromonospora
species
have
been
identified
as
significant
sources
of
anticancer
compounds.
This
work
aimed
perform
polyphasic
approach
isolated
strain
conduct
comparative
metabolomic
genomic
analyses
identify
compounds
with
activity.
The
study
utilized
on
strains
for
compound
identification.
Taxonomic
analysis
2MTK254
revealed
unique
pigment
fatty
acid
patterns,
designating
it
novel
carbonacea
subsp.
caeruleus.
Its
crude
extract
displayed
anti-colorectal
activity
(66.03%
inhibition).
Molecular
network
classified
metabolites
into
eight
classes,
highlighting
polycyclic
tetramate
macrolactams
(PTMs)
(P1,
C29H38N2O4)
99.31%
inhibitory
against
HCT-116
cell
lines
(IC50
at
0.125
µM).
Genome
32
biosynthetic
gene
clusters
(BGCs),
including
PTMs
BGCs
(83%
similarity)
linked
the
P1
compound.
Thus,
M.
caeruleus
holds
promise
source
cancer
potential.
•
A
was
in
Thailand
new
macrolactam
(PTM)
genome
has
secondary
metabolite
Marine Drugs,
Journal Year:
2025,
Volume and Issue:
23(3), P. 116 - 116
Published: March 7, 2025
Marine
microorganisms
have
emerged
as
prolific
sources
of
bioactive
natural
products,
offering
a
large
chemical
diversity
and
broad
spectrum
biological
activities.
Over
the
past
decade,
significant
progress
has
been
made
in
discovering
characterizing
these
compounds,
pushed
by
technological
innovations
genomics,
metabolomics,
bioinformatics.
Furthermore,
innovative
isolation
cultivation
approaches
improved
rare
difficult-to-culture
marine
microbes,
leading
to
identification
novel
secondary
metabolites.
Advances
synthetic
biology
metabolic
engineering
further
optimized
product
yields
generation
compounds
with
properties.
This
review
highlights
key
developments
exploitation
bacteria,
fungi,
microalgae
for
discovery
products
potential
applications
diverse
fields,
underscoring
immense
growing
Blue
Economy
sector.
Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 21, 2025
Synthetic
biology
has
played
an
important
role
in
the
renaissance
of
natural
products
research
during
post-genomics
era.
The
development
and
integration
new
tools
have
transformed
workflow
product
discovery
engineering,
generating
multidisciplinary
interest
field.
In
this
review,
we
summarize
recent
developments
biosynthesis
from
three
different
aspects.
First,
advances
bioinformatics,
experimental,
analytical
to
identify
associated
with
predicted
biosynthetic
gene
clusters
(BGCs)
will
be
covered.
This
followed
by
extensive
review
on
heterologous
expression
bacterial,
fungal
plant
organisms.
native
host-independent
paradigm
identification,
pathway
characterization,
enzyme
is
where
synthetic
most
prominent
role.
Lastly,
strategies
engineer
pathways
for
structural
diversification
complexity
generation
discussed,
including
assembly-line
megasynthase
precursor-directed
modification,
combinatorial
biosynthesis.
