Encapsulation of Phloroglucinol from Rosenvingea intricata Macroalgae with Zinc Oxide Nanoparticles against A549 Lung Cancer Cells DOI Creative Commons
Sakthivel Muthu, Mythileeswari Lakshmikanthan,

Edwin Edward-Sam

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1300 - 1300

Published: Oct. 5, 2024

Background/Objectives: Phloroglucinol (PHL), a phenolic compound extracted from the brown alga Rosenvingea intricata, exhibits potent antioxidant and anticancer properties. This study aims to extract, purify, characterize PHL, further develop functionalized zinc oxide nanoparticles (ZnO NPs) loaded with PHL enhance its therapeutic potential. Methods: was using acetone purified through Sephadex LH-20 column chromatography, yielding highly enriched fraction (F-3). The characterized by FTIR, HPLC, NMR, LC-MS. ZnO NPs were synthesized, PEGylated, conjugated forming ZnO-PEG-PHL NPs. Their characterization included DLS, zeta potential, XRD, SEM-EDAX, encapsulation efficiency studies. Antioxidant assays (DPPH, FRAP, ABTS, RPA) performed in vitro cytotoxicity on A549 lung cancer cells determined evaluate efficacy of PHL. Results: showed high content (45.65 mg/g), which confirmed spectral analysis. increased size 32.36 nm 46.68 nm, their potential shifting −37.87 mV −26.82 mV. activity superior for all assays, while tests an IC50 40 µg/mL compared 60 70 Apoptotic studies revealed significant cell cycle arrest apoptosis induction. Conclusions: synthesized demonstrated enhanced properties, making them promising candidates therapy applications.

Language: Английский

A study on transboundary governance of marine plastic debris—the case of an adjacent waters between China and Taiwan DOI
Hsiang‐Yu Ma,

Jui‐Chung Kao,

Rui‐Hsin Kao

et al.

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(8), P. 11842 - 11856

Published: Jan. 15, 2024

Language: Английский

Citations

1
Exploration of Sargassum wightii: Extraction, Phytochemical Analysis, and Antioxidant Potential of Polyphenol DOI Open Access
S. Bharathi,

Dhanraj Ganapathy

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: July 2, 2024

Background The marine environment, with its rich biodiversity and nutrient-dense ecosystems, offers immense potential for discovering novel pharmaceutical products.

Language: Английский

Citations

1
Natural Products in the Treatment of Retinopathy of Prematurity: Exploring Therapeutic Potentials DOI Open Access

Jong-Ik Heo,

Juhee Ryu

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8461 - 8461

Published: Aug. 2, 2024

Retinopathy of prematurity (ROP) is a vascular disorder affecting the retinas preterm infants. This condition arises when infants in incubators are exposed to high oxygen levels, leading oxidative stress, inflammatory responses, and downregulation endothelial growth factors, which causes loss retinal microvascular capillaries. Upon returning room air, upregulation factors results abnormal cells. Without appropriate intervention, ROP can progress blindness. The prevalence has risen, making it significant cause childhood Current treatments, such as laser therapy various pharmacologic approaches, limited by their potential for severe adverse effects. Therefore, deeper understanding ROP’s pathophysiology development innovative treatments imperative. Natural products from plants, fungi, bacteria, marine organisms have shown promise treating diseases gained attention research due minimal side effects wide-ranging beneficial properties. review discusses roles mechanisms natural that hold therapeutic agents management.

Language: Английский

Citations

1
Multiple health outcomes associated with algae and its extracts supplementation: An umbrella review of systematic reviews and meta‐analyses DOI Open Access
Caixia Wang, Ruixue Min,

Qilun Zhou

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(11), P. 5162 - 5183

Published: Aug. 20, 2024

Abstract Algae and its extracts, widely consumed as functional foods, offer numerous health benefits; however, a comprehensive systematic summary of clinical evidence is currently lacking. The study was to assess the available provide an accurate estimate overall effects algae extracts supplementation on various outcomes. searches in PubMed, Scopus, Embase, Web Science, Cochrane Library until December 22, 2023 were implemented. random‐effects model employed pool effect sizes (ESs) corresponding 95% confidence intervals (CIs) using Stata software. Moreover, detecting methodological quality level eligible studies by A Measurement Tool Assess Systematic Review 2 (AMSTAR2) Grading Recommendations Assessment Development Evaluation. Ultimately, 25 articles covering 133 outcomes included this umbrella review. pooled results demonstrated that could significantly decrease body weight (ES = −1.65; CI: −1.97, −1.34; p < 0.001), mass index (BMI) −0.42; −0.78, −0.07; 0.020), waist circumference (WC) −1.40; −1.40, −1.39; triglyceride (TG) −1.38; −2.15, −0.62; total cholesterol (TC) (ES: −2.09, −0.72; very low‐density lipoprotein (VLDL‐C) −7.85; −8.55, −7.15; fasting blood glucose −2.68; −4.57, −0.79; 0.005), glycated hemoglobin (HbA1c) −0.15; −0.24, systolic pressure −3.21; −5.25, −1.17; 0.002), diastolic −3.84; −7.02, −0.65; 0.018), alanine transaminase −0.70, −0.14; 0.003), alkaline phosphatase −0.54; −0.99, −0.10; 0.017). Due limited number studies, no benefit displayed markers inflammation oxidative stress. Considering suboptimal insufficient pertaining certain outcomes, further well‐designed research imperative substantiate observed findings.

Language: Английский

Citations

1
Encapsulation of Phloroglucinol from Rosenvingea intricata Macroalgae with Zinc Oxide Nanoparticles against A549 Lung Cancer Cells DOI Creative Commons
Sakthivel Muthu, Mythileeswari Lakshmikanthan,

Edwin Edward-Sam

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1300 - 1300

Published: Oct. 5, 2024

Background/Objectives: Phloroglucinol (PHL), a phenolic compound extracted from the brown alga Rosenvingea intricata, exhibits potent antioxidant and anticancer properties. This study aims to extract, purify, characterize PHL, further develop functionalized zinc oxide nanoparticles (ZnO NPs) loaded with PHL enhance its therapeutic potential. Methods: was using acetone purified through Sephadex LH-20 column chromatography, yielding highly enriched fraction (F-3). The characterized by FTIR, HPLC, NMR, LC-MS. ZnO NPs were synthesized, PEGylated, conjugated forming ZnO-PEG-PHL NPs. Their characterization included DLS, zeta potential, XRD, SEM-EDAX, encapsulation efficiency studies. Antioxidant assays (DPPH, FRAP, ABTS, RPA) performed in vitro cytotoxicity on A549 lung cancer cells determined evaluate efficacy of PHL. Results: showed high content (45.65 mg/g), which confirmed spectral analysis. increased size 32.36 nm 46.68 nm, their potential shifting −37.87 mV −26.82 mV. activity superior for all assays, while tests an IC50 40 µg/mL compared 60 70 Apoptotic studies revealed significant cell cycle arrest apoptosis induction. Conclusions: synthesized demonstrated enhanced properties, making them promising candidates therapy applications.

Language: Английский

Citations

1