Phytochemistry Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
Abstract
Throughout
history,
various
human
civilizations
have
used
raw
materials
obtained
from
the
body
parts,
metabolic
byproducts,
or
non-animal
components
of
animals
as
medical
resources
for
treatment
numerous
diseases
and
relief
symptoms.
Protein
structures,
including
hormones
enzymes,
well
animal-derived
metabolites
polysaccharides,
lipids,
vitamins,
been
development
drugs.
These
chemicals
include
widely
substances
heparin,
melatonin,
collagen,
glucosamine,
chondroitin,
bile
acids,
coenzyme
Q10.
Additionally,
they
such
snake,
spider,
amphibian
poisons,
which
are
now
undergoing
therapeutic
development.
This
review
presents
examples
pharmaceutical
that
being
drugs
potential
in
drug
research.
Detailed
descriptions
chemical
original
sources
effects
these
included.
In
general,
production
method
was
previously
carried
out
by
using
animal
organisms
has
replaced
utilization
recombinant
technologies.
The
use
a
resource
process
is
expected
to
remain
an
interesting
topic
further
research
this
area
expected.
Nevertheless,
it
essential
not
disregard
suggestions
against
utilizing
production,
particularly
cases
where
alternative
accessible.
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(7), P. 577 - 577
Published: March 26, 2024
Titanium
and
its
alloys
are
extensively
applied
in
artificial
tooth
roots
because
of
their
excellent
corrosion
resistance,
high
specific
strength,
low
elastic
modulus.
However,
biological
inertness,
surface
needs
to
be
modified
improve
the
osteointegration
titanium
implants.
The
preparation
biologically
active
calcium–phosphorus
coatings
on
an
implant
is
one
effective
method
for
enhancing
likelihood
bone
integration.
In
this
study,
osteoinductive
peptides
were
extracted
from
oyster
shells
by
using
acetic
acid.
Two
peptide-containing
hydroxyapatite
(HA)
composite
then
prepared:
coating
was
prepared
hydrothermally
synthesizing
HA
presence
(HA/P/M),
other
immersing
synthesized
a
peptide
solution
(HA/P/S).
Characterization
results
indicated
that
containing
shell-based
successfully
alkali-treated
pure
surfaces.
HA/P/M
HA/P/S
found
exhibit
hydrophilicity.
Protein
adsorption
tests
confirmed
had
approximately
2.3
times
higher
concentration
adsorbed
proteins
than
coating.
Biosensors,
Journal Year:
2024,
Volume and Issue:
14(4), P. 203 - 203
Published: April 19, 2024
Marine
biotoxins
(MBs),
harmful
metabolites
of
marine
organisms,
pose
a
significant
threat
to
ecosystems
and
human
health
due
their
diverse
composition
widespread
occurrence.
Consequently,
rapid
efficient
detection
technology
is
crucial
for
maintaining
ecosystem
health.
In
recent
years,
has
garnered
considerable
attention
its
pivotal
role
in
identifying
MBs,
with
advancements
sensitivity,
specificity,
accuracy.
These
technologies
offer
attributes
such
as
speed,
high
throughput,
automation,
thereby
meeting
requirements
across
various
scenarios.
This
review
provides
an
overview
the
classification
risks
associated
MBs.
It
briefly
outlines
current
research
status
biotoxin
biosensors
introduces
fundamental
principles,
advantages,
limitations
optical,
electrochemical,
piezoelectric
biosensors.
Additionally,
explores
applications
MBs
presents
forward-looking
perspectives
on
development,
which
aims
be
comprehensive
resource
design
implementation
tailored
effective
MB
detection.
Animal Microbiome,
Journal Year:
2025,
Volume and Issue:
7(1)
Published: Jan. 11, 2025
In
holobiont,
microbiota
is
known
to
play
a
central
role
on
the
health
and
immunity
of
its
host.
Then,
understanding
microbiota,
dynamic
according
environmental
conditions
link
would
help
react
potential
dysbiosis
aquacultured
species.
While
gut
highly
studied,
in
marine
invertebrates
hemolymph
often
set
aside
even
if
it
remains
an
important
actor
homeostasis.
Indeed,
harbors
factors
involved
animal
homeostasis
that
interacts
with
immunity.
Southwest
Pacific,
high
economical
valued
shrimp
Penaeus
stylirostris
reared
two
contrasted
sites,
New
Caledonia
(NC)
French
Polynesia
(FP).
We
characterized
active
inhabiting
shrimps
while
considering
stability
during
seasons
at
one-month
interval
evidenced
microbial
variability
between
rearing
sites.
highlighted
specific
biomarkers
along
common
core
composed
6
ASVs.
Putative
functions
were
mostly
associated
bacterial
competition,
infections
metabolism
NC,
they
cell
FP
suggesting
site
discrimination.
Differential
relative
expression
immune
effectors
measured
populations
from
NC
FP,
exhibited
higher
level
compared
FP.
addition,
differential
was
correlated
based
their
geographical
location.
Our
data
suggest
that,
Pacific
shrimps,
both
could
have
undergone
immunostimulation
as
well
adaptative
divergence
Further,
identification
proxies
such
biomarkers,
be
used
guide
future
actions
monitor
thus
preserve
productions.
Marine Drugs,
Journal Year:
2025,
Volume and Issue:
23(2), P. 79 - 79
Published: Feb. 11, 2025
Sea
anemones
(Actiniaria,
Cnidaria)
are
promising
targets
for
biomedical
research,
as
they
produce
unique
bioactive
compounds,
including
toxins
and
antimicrobial
peptides
(AMPs).
However,
the
diversity
mechanisms
underlying
their
chemical
defenses
remain
poorly
understood.
In
this
study,
we
investigate
proteomic
profiles
of
unexplored
sea
anemone
Actinia
fragacea
by
analyzing
its
venom
nematocyst
extract,
tissues,
mucus
secretion.
A
total
4011
different
proteins
were
identified,
clustered
into
3383
protein
groups.
Among
83
putative
detected,
actinoporins,
neurotoxins,
phospholipase
A2
uncovered,
well
two
novel
zinc
metalloproteinases
with
specific
domains
(ShK)
associated
potassium
channel
inhibition.
Common
Gene
Ontology
(GO)
terms
related
to
immune
responses,
cell
adhesion,
protease
inhibition,
tissue
regeneration.
Furthermore,
1406
13,276
distinct
identified
predicted
potential
AMPs,
a
Aurelin-like
AMP
localized
within
nematocysts.
This
discovery
highlights
strengthens
evidence
cnidarian-exclusive
Aurelin
peptide
family.
Several
other
compounds
distinctive
defense
functions
also
enzymes,
pattern
recognition
(PRPs),
neuropeptides.
study
provides
first
proteome
map
A.
fragacea,
offering
critical
foundation
exploring
valuable
insights
molecular
complexity.