From Ocean to Medicine: Harnessing Seaweed’s Potential for Drug Development

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 797 - 797

Published: Jan. 8, 2024

Seaweed, a miscellaneous group of marine algae, has long been recognized for its rich nutritional composition and bioactive compounds, being considered nutraceutical ingredient. This revision delves into the promising role seaweed-derived nutrients as beneficial resource drug discovery innovative product development. Seaweeds are abundant sources essential vitamins, minerals, polysaccharides, polyphenols, unique secondary metabolites, which reveal wide range biological activities. These compounds possess potential therapeutic properties, making them intriguing candidates leads in various medical applications pharmaceutical It explores their pharmacological including antioxidant, anti-inflammatory, antimicrobial, anticancer activities, shedding light on agents. Moreover, manuscript provides insights development formulation strategies delivery systems to enhance bioavailability stability compounds. The also discusses challenges opportunities associated with integration seaweed-based industries. Regulatory considerations, sustainability, scalability sustainable seaweed sourcing cultivation methods addressed, emphasizing need holistic approach harnessing seaweed's potential. underscores immense valuable reservoir By bridging gap between biology, pharmacology, formulation, this research contributes critical advancement solutions sectors.

Language: Английский

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Polysaccharides: The Sweet and Bitter Impacts on Cardiovascular Risk

Polymers, Journal Year: 2025, Volume and Issue: 17(3), P. 405 - 405

Published: Feb. 3, 2025

Cardiovascular risk is a clinical factor that represents the probability of developing cardiovascular diseases (CVDs). This shaped by non-modifiable and modifiable factors, including dietary patterns, which are main lifestyle influencing CVD. Dietary polysaccharides, integral to nutrition, have varying effects on health depending their type source. They include starches, non-starch prebiotic fibers, categorized further into soluble insoluble fibers. Soluble found in oats, legumes, fruits, dissolve water, forming gels help lower serum cholesterol modulate blood glucose levels. Insoluble present whole grains vegetables, aid bowel regularity. The benefits polysaccharides linked ability bind bile acids, reducing levels, production short-chain fatty acids gut microbiota, anti-inflammatory properties. However, not all beneficial; refined starches can lead adverse metabolic effects, chitosan mixed microbiota. review examines dualistic nature highlighting beneficial roles factors potential specific types.

Language: Английский

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Marine-Derived Anticancer Agents Targeting Apoptotic Pathways: Exploring the Depths for Novel Cancer Therapies

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(3), P. 114 - 114

Published: Feb. 28, 2024

Extensive research has been conducted on the isolation and study of bioactive compounds derived from marine sources. Several natural products have demonstrated potential as inducers apoptosis are currently under investigation in clinical trials. These marine-derived selectively interact with extrinsic intrinsic apoptotic pathways using a variety molecular mechanisms, resulting cell shrinkage, chromatin condensation, cytoplasmic blebs, bodies, phagocytosis by adjacent parenchymal cells, neoplastic or macrophages. Numerous undergoing rigorous examination for their application cancer therapy. This review examines total 21 compounds, along synthetic derivatives, sourced organisms such sponges, corals, tunicates, mollusks, ascidians, algae, cyanobacteria, fungi, actinobacteria. preclinical trials to evaluate treatment different types cancer. further examined compound’s properties mode action, investigations, trial studies single combination therapy, prospective development anticancer therapies.

Language: Английский

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Seaweed as a Safe Nutraceutical Food: How to Increase Human Welfare?

Nutraceuticals, Journal Year: 2024, Volume and Issue: 4(3), P. 323 - 362

Published: June 29, 2024

Seaweeds have been utilized for millennia in Asian countries, although they only more recently become popular Western society. They began to be used ancient times because of their long-term properties and, nowadays, seaweeds are being targeted as a potential tool combat climate change. There not many laws governing just lately food. However, guidelines developed regulate manufacture and use. Because seaweed’s tendency accumulate components, whether helpful or poisonous, limited doses certain substances established prevent consumer overdosage. Aside from chemical safety, microbiological safety is important people, preventing any pathogen spreading infecting critical. As result, systems ways safeguard consumers must developed. various seaweed species varied compositions, may safer nutraceuticals than others. To ensure the seaweed-based food items, HACCP (Hazard Analysis Critical Control Point) system needs used. The majority consumed come aquaculture; however, others wild harvesting. success cultures, waters tested chemicals biological risks, well pH, salinity, temperature. enormous promise industries, but industry, beginning play major role, seizing chances produce innovative, safe, sustainable sources strongly advised. This critical review investigates real human source nutraceutical solution. also focuses on usage product procedures required prepare it. In addition, it compiles information applicable legislation regulations, addresses lengthy road that has traveled increase well-being by employing new controlled manner while simultaneously reducing population’s health problems.

Language: Английский

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Exploring algal diversity for enhanced nutrition: Implications for human health and sustainability

Algal Research, Journal Year: 2025, Volume and Issue: 86, P. 103907 - 103907

Published: Jan. 10, 2025

Language: Английский

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Algal Proteins for Sustainable Nutrition and Functional Food Innovation

Applied Food Research, Journal Year: 2025, Volume and Issue: unknown, P. 100752 - 100752

Published: Feb. 1, 2025

Language: Английский

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Advance of the application of seaweed polysaccharides on antitumor drug delivery systems

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125502 - 125502

Published: March 1, 2025

Language: Английский

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Marine-Derived Antioxidants: A Comprehensive Review of Their Therapeutic Potential in Oxidative Stress-Associated Diseases

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(6), P. 223 - 223

Published: May 22, 2025

Oxidative stress is a critical factor contributing to the pathogenesis of numerous diseases, including cardiovascular disorders, diabetes, and neurodegenerative conditions. In recent years, marine-derived antioxidants have emerged as promising therapeutic agents due their unique biological activities diverse sources. This comprehensive review explores potential various marine in mitigating oxidative stress-associated diseases. Marine organisms are rich bioactive compounds, such polysaccharides, polyphenols, carotenoids, peptides, vitamins, which exhibit potent antioxidant free radical scavenging abilities. These compounds been shown effectively inhibit reactions, repair damage, enhance body’s defense mechanisms. For instance, polysaccharides derivatives can scavenge reactive oxygen species (ROS), protect neurons from alleviate inflammation diseases like Alzheimer’s Parkinson’s Similarly, unsaturated fatty acids, omega-3 polyunsaturated acids (PUFAs), found reduce risks by lowering serum triglyceride levels improving vascular endothelial function. Additionally, superoxide dismutase (SOD) plays crucial role neutralizing ROS, thereby offering protection against Despite these findings, challenges remain field, need for improved extraction purification technologies, more activity evaluation systems, further research into safety bioavailability compounds. provides detailed overview current status, highlighting types, structural characteristics, activities, mechanisms action antioxidants. It also identifies key areas future development, aiming harness full prevention treatment stress-related

Language: Английский

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Seaweeds as Source of Bioactive Pigments with Neuroprotective and/or Anti-Neurodegenerative Activities: Astaxanthin and Fucoxanthin

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(7), P. 327 - 327

Published: July 22, 2024

The marine kingdom is an important source of a huge variety scaffolds inspiring the design new drugs. complex molecules found in oceans present great challenge to organic and medicinal chemists. However, wide biological activities they can display worth effort. In this article, we overview different seaweeds as potential sources bioactive pigments with activity against neurodegenerative diseases, especially due their neuroprotective effects. Along broad introduction seaweed pigments, review focused on astaxanthin fucoxanthin and/or anti-neurodegenerative agents. PubMed SciFinder were used main search select most relevant scientific articles within field.

Language: Английский

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Comparative analysis of nutritional composition and bioactive properties of Chlorella vulgaris and Arthrospira platensis: Implications for functional foods and dietary supplements

Open Chemistry, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 1, 2025

Abstract The rising incidence of chronic diseases has spurred interest in functional foods rich antioxidants and essential nutrients, as well exploring their potential cytotoxic activity against cancer cells. This study aims to address this gap by providing a comprehensive comparison biochemical composition bioactive properties, offering insights into targeted applications supplements. investigated the nutritional properties two algae species, chlorella ( Chlorella vulgaris ) spirulina Arthrospira platensis ). Analysis included total protein content, amino acid profiles, mineral compositions, fatty B vitamin contents, polyphenol carotenoid antioxidant activities (DPPH˙ ABTS + assays), activities. exhibited higher content (64.63%) compared (58.24%). Spirulina showed concentrations non-essential acids, except for methionine. Mineral analysis revealed spirulina’s superiority calcium, potassium, sodium, iron, manganese, zinc, whereas contained copper lead levels. Fatty indicated chlorella’s dominance saturated while proportions monounsaturated polyunsaturated acids. Polyphenol highlighted levels p -hydroxybenzoic acid, more rutin catechin. also niacin riboflavin spirulina. Additionally, extracts, whether ethanolic or hexane-based, demonstrate substantial effects, evidenced lower IC 50 values both DPPH˙ assays relative chlorella. Overall, superior effect. hexane extract slightly These findings enhance our understanding health-promoting spirulina, suggesting dietary While vitro indicate promising bioactivity, future studies should include vivo experiments confirm health benefits these microalgae.

Language: Английский

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